297 results about "Biphenyl compound" patented technology

This invention provides compounds of formula I:wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

The invention belongs to the field of agricultural acaricides, and concretely relates to a biphenyl compound and an application thereof. The structure of the compound is represented by general formula I, and all substituent groups in the general formula I are defined in the description. The compound of the general formula I has excellent acaricidal activity, and can be used to prevent and control various mite damages.

This invention provides compounds of formula I:wherein a, b, c, m, p, s, t, W, Ar1, X1, R1, R2, R3, R4, R6, and R7 are as defined specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

This invention provides compounds of formula I: wherein a, b, c, m, p, r, R1, R2, R3, R4, R5, R6, W and X1 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, r, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

This invention provides compounds of formula I:wherein a, b, c, d, m, n, p, s, t, Ar1, R1, R2, R3, R4, R6, R7, R8, and W are as defined in the specification. The compounds of formula I are mescaline receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

A system and method for detecting trace explosives is provided that utilizes a lumnescent reagent, such as blue-fluorescent biphenyl compound, to simultaneously detect multiple nitrogen-based explosives on a sample substrate. The test reagent is mixed with a solvent to improve mixing and maximize the dissolution of the reagent and any trace explosives present on the substrate. A thin film of reagent is applied to the substrate either before or after the substrate contacts a sample area to be tested. Heated air is then applied to the substrate to improve the sample reading. A light source is utilized to illuminate the reagent and expose any quenched portions of the substrate that indicate the presence of an explosive. Quenched portions may be detected visually, or utilizing an analyzing apparatus, such as a fluorimeter or camera. A computer may also be utilized to interpret and record test results.

This invention provides an air-enhanced method for preparing biphenyl compounds from chlorinated aromatic hydrocarbons and aryl boric acid by Suzuki crosslinking reaction catalyzed by nanoscale Pd in situ grown in poly(ethylene glycol). The method does not need any ligand, phase transfer agent, promoter or inert gas protection. Catalyzed by nanoscale Pd in situ grown in poly (ethylene glycol), chlorinated aromatic hydrocarbons and aryl boric acid react in a mild condition to obtain biphenyl compounds with a high efficiency. In an optimized condition, the conversion rate of chlorinated aromatic hydrocarbons and the yield of biphenyl compounds are 95-100% and 90-99%, respectively.

A process for the preparation of a biphenyl-containing compound of general formula I: wherein R1 is a C3-6 carbonyl containing compound; R2 is a substituted or unsubstituted, straight or branched C3-6 alkyl group, or R1 and R2 together with the nitrogen atom to which they are bonded are joined together to form a substituted heterocyclic group selected from the group consisting of substituted or unsubstituted imidazoles, substituted or unsubstituted benzimidazoles and substituted or unsubstituted 1,3-diazaspiro[4,4]non-1-en-4-one; and R3 is a carboxylic acid ester, cyano, a substituted or unsubstituted 1H-tetrazolyl group or a substituted or unsubstituted group which may be converted in vivo into a carboxy group is provided, the process comprising reacting a compound of general formula II: wherein R1 and R2 have the aforestated meanings with a compound of general formula III: wherein Z is a leaving group and R3 has the aforestated meaning in a biphasic solvent system in the presence of a phase transfer catalyst.

A process is described for converting at least one isomer of a dialkyl-substituted biphenyl compound, such as at least one 2,X′ dialkylbiphenyl isomer (where X′ is 2′, 3′ and / or 4′), into at least one different isomer, 3,3′, 3,4′ and / or 4,4′ dialkylbiphenyl isomer. The process comprises contacting a feed comprising the dialkyl-substituted biphenyl compound isomer with an acid catalyst under isomerization conditions.

The problem that the invention object to resolve is to provide a polymerizable compound, which has excellent solubility with other liquid crystal compounds during constituting a polymerizable liquid crystal composition, and displays excellent heat-resistant quality and mechanical intensity during curing the polymerizable liquid crystal composition. The invention provides a polymerizable compound represented by formula (I), and a liquid crystal composition taking the compound as the constitution material, and further provides an optical anisotropy body or liquid crystal device using the liquid crystal composition. As the inventive polymerizable compound has excellent solubility with other liquid crystal compounds, it is useful as the constitution material of the polymerizable compound. In addition, the polymerizable composition containing the inventive polymerizable compound has wide liquid crystal phase temperature range; the optical anisotropy body of the polymerism composition has high heat-resistant quality, and is useful in phase difference plates and the like applications.

A photocatalysis synthesis method of biphenyl compounds comprises steps as follows: halogenobenzene compounds, phenylboronic acid compounds and alkaline are uniformly mixed at the mole ratio of 1: (1-2): (1-3) and are sufficiently dissolved by an organic reagent with water volume fraction of 5%-50%, a palladium / silicon carbide catalyst with 0.5%-10% of palladium by weight is added, the mole ratio of palladium and halogenobenzene is (1-30) : 10,000, the mixture is uniformly stirred, and a suspension liquid is obtained; the well dispersed suspension liquid is stirred at the oxygen-free atmosphere at the temperature of 20 DEG-100 DEG C, the mixture is irradiated by visible light for reaction for 30-300 minutes, and the biphenyl compounds can be obtained. The photocatalysis synthesis method has the advantages of environmental protection, low cost, simplicity in operation, short reaction period and high product yield.

The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. In an additional aspect, the invention provides methods of screening for compounds that will bind to a KSP kinesin, for example compounds that will displace or compete with the binding of the compounds of the invention. The methods comprise combining a labeled compound of the invention, a KSP kinesin, and at least one candidate agent and determining the binding of the candidate bioactive agent to the KSP kinesin. In a further aspect, the invention provides methods of screening for modulators of KSP kinesin activity. The methods comprise combining a compound of the invention, a KSP kinesin, and at least one candidate agent and determining the effect of the candidate bioactive agent on the KSP kinesin activity.

The invention relates to a green synthesis method of a bromomethylbiphenyl compound, comprising the following steps: dissolving a 4'-methyl-2-substituted biphenyl compound in an organic solvent, adding a bromizating agent to carry out bromination reaction and controlling the reaction conditions to obtain the bromomethylbiphenyl compound. The invention is characterized in that the reaction is carried out in light.

A preparing method of a stilbene biphenyl fluorescent brightener comprises performing desalting secondary refining to a filter cake containing the stilbene biphenyl fluorescent brightener; pulping the filter cake; homogenizing serosity through a colloid mill or a high-pressure homogenizer so as to guarantee that fineness of particles in the serosity is 10-100mum; and finally performing spray drying to the serosity to obtain a product. Effective component(s) of the filter cake containing the stilbene biphenyl fluorescent brightener is / are one of or a mixture of a plurality of sulfonyl styryl biphenyl compounds. The preparing method enables the fluorescent brightener having high water solubility at a normal temperature to be obtained, and has the effects of saving energy and reducing production cost.

A method is disclosed for making hydroxy-substituted ethynylated biphenyl compounds and for reacting such compounds with a family of noncross-linking thermosetting poly(arylene ethers) to produce novel poly(arylene ether) compositions which, when cured at glass transition temperatures greater than about 350° C. to form thin films, possess properties such as low dielectric constant, low moisture absorption, and high thermal stability. These films are suitable for use as intermetal dielectrics for multilevel interconnection.

The invention provides a terphenyl bridged double-benzimidazoles compound as well as a synthesis method and application thereof. The invention takes cyanophoric phenyloboricacid and aromatic dibromide (such as 1,4-dibromo-benzene, 2-fluorine-1, 4-dibromo-benzene, 2,5-dibromo-toluene) as raw materials; under the catalysis of organic palladium and inorganic base, a series of terphenyl compounds with di-cyan can be synthesized by the Suzuki coupling reaction; and then a series of terphenyl bridged double-benzimidazoles compounds can be obtained by adding 1 time of di-cyano-terphenyl compounds and 2-2.4 times of o-phenylenediamine compounds, taking polyphosphoric acid as the catalyst and carrying out the condensation reaction for 6-24 hours under 180-240 degrees C.. The compound can be applied to the fields such as light emitting devices, photovoltaic cells, organic light-emitting diodes and the like as the organic blue-light material or the electron transport material.

The invention discloses a synthetic method of biphenyl compounds which is prepared through adding alkalis, alcohol and halogenated aromatic compounds into water, mixing it to form microemulsion system, then adding Pd / C as catalyst, reacting 2 to 10h at 50 to 120 DEG C, postprocessing the resultant of reaction to obtain the biphenyl compounds. The present invention is characterized in that using alcohol as additive agent, using lower price Pd catalyst, having features of lower cost, short reaction time, high yield, no pollution and in favor of industrialization.

The invention relates to a synthetic method of biphenyl compounds. Based on novel coupling reaction of phenylhydrazine or benzenesulfonyl hydrazide, the phenylhydrazine or benzenesulfonyl hydrazide is used as a substrate, and coupled after being acted by transition metal in a catalytic manner, so that the biphenyl compounds can be conveniently and effectively combined. Compared with the existing method, the synthetic method disclosed by the invention is extensive in applicable substrate range, mild in reaction condition, simple and convenient to operate and high in reaction efficiency, and is a method with important application value. The method disclosed by the invention is further used for synthesizing biphenyl compounds containing halogens. The invention provides a simple, novel and efficient method.

The invention relates to a synthetic method for 4,4'-dihalogenated-3,3'-dialkyl(alkoxyl) biphenyl compounds. The method employs o-nitro alkyl (alkoxyl) benzene as an initial raw material, 2,2'-dialkyl(alkoxyl) hydrazobenzene is prepared through catalysis hydrogenation in an alkaline environment, hydrochloric acid acidifying rearrangement is carried out, 4,4'-diamino-3,3'-dialkyl(alkoxyl) biphenyl is prepared, finally, a diazotization reaction is carried out and 4,4'-dihalogenated-3,3'-dialkyl(alkoxyl) biphenyl compounds are prepared. The synthetic method is advantaged by cheap and easily available raw materials, mild reaction conditions, simple operation, high safety coefficient, high yield and low cost.