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51 results about "Arenavirus" patented technology

An arenavirus is a negative-sense, single-stranded RNA virus that is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans; arenaviruses have also been discovered which infect snakes. At least eight arenaviruses are known to cause human disease. The diseases derived from arenaviruses range in severity. Aseptic meningitis, a severe human disease that causes inflammation covering the brain and spinal cord, can arise from the lymphocytic choriomeningitis virus (LCMV) infection. Hemorrhagic fever syndromes, including Lassa fever, are derived from infections such as Guanarito virus (GTOV), Junin virus (JUNV), Lassa virus (LASV), Lujo virus (LUJV), Machupo virus (MACV), Sabia virus (SABV), or Whitewater Arroyo virus (WWAV). Arenaviruses are divided into two groups: the Old World and the New World viruses. The differences between these groups are distinguished geographically and genetically. Because of the epidemiological association with rodents, some arenaviruses and bunyaviruses are designated as roboviruses.

HPV vaccines

Provided herein are genetically modified arenaviruses suitable as vaccines against neoplastic diseases or cancer. The invention also relates to pharmaceutical compositions and methods for the prevention or treatment of certain infections causing neoplastic diseases or cancer, such as infections with oncogenic viruses. Specifically, provided herein are pharmaceutical compositions, vaccines, and methods of preventing or treating diseases and conditions caused by and associated with infections with Human Papillomavirus (HPV), such as cervical cancer, anogenital cancer, head and neck cancer and skin cancers. Also provided herein are immunotherapies for the treatment of a neoplastic disease, such as a neoplastic disease caused by infection with oncogenic viruses.
Owner:HOOKIPA BIOTECH GMBH

Novel effective antiviral compounds and methods using same

The present invention includes compounds that are useful in preventing or treating viral infections caused by an enveloped RNA virus, such as viral infections caused by a Filovirus, arenavirus, rhabdovirus, paramyxovirus, orthomyxovirus and / or retrovirus. The present invention further includes compositions comprising such compounds, and methods of treating a viral infection in a subject using such compounds.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

Application of lacidipine to preparing medicines for treating arenavirus infection

The invention provides application of lacidipine to preparing medicines for treating arenavirus infection, and belongs to the field of medicines. The application has the advantages that invasion of arenavirus into host cells can be effectively inhibited by the lacidipine in non-toxicity ranges, and accordingly virus infection due to the arenavirus can be effectively prevented and treated; the lacidipine is excellent in safety, further can be developed to obtain the medicines for treating or preventing the arenavirus infection and has a broad application prospect; the lacidipine further can be applied to preparing medicines for treating virus infection mediated by arenavirus envelope glycoprotein compounds and can act on the arenavirus envelope glycoprotein compounds, and accordingly the virus infection mediated by the arenavirus envelope glycoprotein compounds can be effectively inhibited; all different types of virus infection mediated by the arenavirus envelope glycoprotein compounds can be effectively treated and prevented by the lacidipine.
Owner:WUHAN INST OF VIROLOGY CHINESE ACADEMY OF SCI

Application of dabrafenib and/or medicinal derivative thereof in preparation of anti-arenavirus drug

ActiveCN111973598AStrong anti-arenavirus effectOrganic active ingredientsAntiviralsDabrafenibPharmaceutical drug
The invention provides an application of dabrafenib and / or a medicinal derivative thereof in preparation of an anti-arenavirus drug. By detecting the cytotoxicity of the dabrafenib on Vero cells and BHK-21 cells and the antiviral activity of the dabrafenib on arenavirus, it is indicated that the dabrafenib shows a relatively high arenavirus resisting effect on the cellular level, and a new direction is provided for prevention and treatment of arenavirus infectious diseases.
Owner:CANVEST WUHAN BIOTECH

Compounds for the treatment of arenavirus infection

Compounds as exemplified by compound A are useful in the treatment of arenavirus infections and viral infections mediated by arenavirus glycoproteins.
Owner:阿里桑治疗药物公司
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