Silicon/zinc ion doped biphase calcium phosphate ceramic scaffold and preparation method thereof

Abstract

The invention discloses a silicon / zinc ion doped biphase calcium phosphate ceramic scaffold and a preparation method thereof.The preparation method comprises the steps that firstly, synthesized silicon ion doped hydroxyapatite powder and zinc ion doped beta-tricalcium phosphate powder are mixed, and a silicon / zinc ion doped biphase calcium phosphate ceramic scaffold blank is prepared through 3D printing; and then carrying out high-temperature sintering to obtain the silicon / zinc ion doped biphase calcium phosphate ceramic scaffold. On the basis, a magnesium-doped calcium silicate precursor is synthesized, slurry is prepared, the surface of a stent is impregnated with the slurry and permeated and coated with the slurry, coating and drying are repeated, then heat treatment is conducted, a magnesium-doped calcium silicate surface layer is formed on the surface of the stent, and finally the surface-modified silicon / zinc ion-doped biphase calcium phosphate ceramic stent is obtained. The preparation method has the advantages that the preparation process is relatively simple, the doping amount and release amount of ions can be adjusted, and multiple active ions synergistically promote osteogenesis and vascularization, and has important significance in expanding clinical application of the calcium phosphate ceramic stent.

Description

technical field [0001] The invention relates to the technical field of medical materials for bone injury repair, in particular to a silicon / zinc ion-doped biphasic calcium phosphate ceramic stent, a surface-modified silicon / zinc ion-doped biphasic calcium phosphate ceramic stent and a preparation method thereof . Background technique [0002] The main inorganic component of bone tissue is hydroxyapatite (HA; the Ca / P molar ratio of HA is 1.67). Synthetic hydroxyapatite has excellent biocompatibility, good osteoconductivity and osteointegration. , HA ceramics have high mechanical properties, but low biodegradability, which is unfavorable for the regeneration and repair of bone defects, which limits its wide application in the field of bone repair. The chemical composition of tricalcium phosphate (TCP; the Ca / P molar ratio of TCP is 1.5) is similar to that of bone minerals, and it also has excellent biocompatibility, good osteoconductivity and osteointegration. Moreover, the...

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Problems solved by technology

[0004] CN107441558A discloses a kind of porous SiO for bone tissue engineering 2 / biphasic calcium phosphate composite stent and its preparation method, but the osteogenesis and vascularization effects of composite silicon oxide are not as good as silicon doping and silicon, zinc co-doping, and polyurethane organic foam pore-forming scaffolds are superior in pore connectivity and The mechanical properties are not as good as those prepared by 3D printing

CN110613863A discloses a porous scaffold material based on silicon-doped hydroxyapatite for promoting vascularization and its preparation method and application. Calcium, phosphorus, and silicon source solutions are added to polyvinyl alcohol solution, and a small amount (2-5wt. %) of silicon-doped hydroxyapatite to prepare a silicon-doped hydroxyapatite porous scaffold material for promoting vascularization, that is, by compounding a small amount of silicon-doped hydroxyapatite to promote stent vascularization, but the content of silicon-doped hydroxyapatite is small and degraded The ion release is very limited, the effect of promoting vascularization is difficult to be significant, and the matrix material of the scaffold is polyvinyl alcohol, so it lacks osteogenic performance

CN107412855A discloses a 3D printing stent with a coating and a preparation method thereof. The dopamine surface-modified polybutylene succinate stent is prepared by 3D printing the polybutylene succinate stent and then impregnated with a dopamine solution. The modified scaffold is coated with mesoporous magnesium silicate microspheres or copper-doped mesoporous magnesium silicate microspheres to obtain a coating of mesoporous magnesium silicate microspheres or copper-doped mesoporous magnesium silicate microspheres. However, the scaffold matrix is ​​artificially synthesized. Organic polymers lack bioactivity and osteogenic properties, and mesoporous magnesium silicate microspheres or copper-doped mesoporous magnesium silicate microspheres are coated on the surface of the dopamine membrane, but the magnesium silicate microspheres cannot be well combined with the dopamine membrane. Especially the dopamine membrane and the microspheres start to degrade and the microspheres are easy to fall off

CN109793923B discloses a preparation method of a nanostructure calcium borosilicate-containing biological coating, in which calcium silicate powder is plasma-sprayed on the surface of a titanium alloy material, then immersed in a sodium borate solution to undergo a hydrothermal reaction to obtain calcium borosilicate Biological coating, the coating has the function of promoting bone differentiation and anti-inflammatory function, but because the thermal expansion coefficient and elastic modulus of calcium borosilicate are greatly different from those of titanium alloy, the coating is prone to occur as time goes by during application Cracking and peeling, the purpose of the patent has nothing to do with promoting vascularization, and the preparation method of the biological coating is not suitable for modifying the calcium phosphate scaffold material with a three-dimensional interconnected porous structure, and cannot construct a modified layer on the inner pore wall of the scaffold material

At present, there are no reports on silicon and zinc double-ion doped biphasic calcium phosphate ceramic scaffolds and their preparation methods

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