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TBJ tissue repair film type stent and preparation method thereof

A tissue repair, film-type technology, applied in the field of biomaterials and medical biomaterials, can solve the problems of insufficient mechanical properties, inability to meet the personalized design and repeatable manufacturing of scaffold materials for tendon and bone repair, and poor clinical treatment effects, etc.

Active Publication Date: 2021-01-22
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The second purpose of the present invention is to provide a method for preparing TBJ tissue repair film-type scaffold material with simple operation, which combines ion doping and mechanical drawing to prepare highly biomimetic tissue characteristics and excellent mechanical properties The scaffold material for tendon and bone repair solves the problem of poor continuity of gradient characteristics, insufficient mechanical properties, and complicated preparation process of the existing TBJ scaffold, which cannot meet the needs of personalized design and repeatable manufacturing of tendon and bone repair scaffold materials, resulting in poor clinical treatment effect. problem

Method used

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  • TBJ tissue repair film type stent and preparation method thereof
  • TBJ tissue repair film type stent and preparation method thereof
  • TBJ tissue repair film type stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] A biocompatible gradient tendon-bone junction based on synergistic construction of nanodoping and mechanical unidirectional drawing at room temperature (21 °C), strain rate of 10 mm / min, and strain of 600% The scaffold is prepared by the following method:

[0058] Step 1: Preparation of composite bioceramic micro-nanoparticles

[0059] According to the design, 0.6mol / L of Ca(OH) 2 solution and 0.03mol / L AgNO 3 After the solution was mixed, it was added dropwise to 0.40mol / L H 3 PO 4 and 0.06mol / L SiC 8 h 20 o 4 In the mixed solution, the pH value of the solution was adjusted to 10.5 by concentrated ammonia water, and the holding time was 3 hours. Si and Ag doped bioceramic micro-nanoparticles were obtained by heat treatment at 300°C for 4 hours. Si can induce and promote tissue osteogenesis, and Ag has good antibacterial effect in the process of tissue formation.

[0060] Step 2: Preparation of Precursor Polymer Membranes in the Tendon Region

[0061] According...

Embodiment 2

[0069] A biocompatible gradient tendon-bone junction based on synergistic construction of nanodoping and mechanical unidirectional drawing at a temperature close to the melting point of PCL (55 °C), a strain rate of 10 mm / min, and a strain of 600%. The dot scaffolds were prepared as follows.

[0070] Step 1: Preparation of composite bioceramic micro-nanoparticles

[0071] According to the design, 0.6mol / L of Ca(OH) 2 solution and 0.03mol / L AgNO 3 After the solution was mixed, it was added dropwise to 0.40mol / L H 3 PO 4 and 0.06mol / L SiC 8 h 20 o 4 In the mixed solution, the pH value of the solution was adjusted to 10.5 by concentrated ammonia water, and the holding time was 3 hours. Si and Ag doped bioceramic micro-nanoparticles were obtained by heat treatment at 300°C for 4 hours. Si can induce and promote tissue osteogenesis, and Ag has good antibacterial effect in the process of tissue formation.

[0072] Step 2: Preparation of Precursor Polymer Membranes in the Ten...

Embodiment 3

[0081]A biocompatible gradient tendon-bone junction based on synergistic construction of nanodoping and mechanical unidirectional drawing at room temperature (21 °C), strain rate of 10 mm / min, and strain of 1000% The scaffold is prepared by the following method:

[0082] Step 1: Preparation of bioceramic micro-nanoparticles

[0083] According to the design, 0.6mol / L of Ca(OH) 2 solution and 0.03mol / L AgNO 3 After the solution was mixed, it was added dropwise to 0.40mol / L H 3 PO 4 and 0.06mol / L SiC 8 h 20 o 4 In the mixed solution, the pH value of the solution was adjusted to 10.5 by concentrated ammonia water, and the holding time was 3 hours. Si and Ag doped bioceramic micro-nanoparticles were obtained by heat treatment at 300°C for 4 hours. Si can induce and promote tissue osteogenesis, and Ag has good antibacterial effect in the process of tissue formation.

[0084] Step 2: Preparation of Precursor Polymer Membranes in the Tendon Region

[0085] According to the de...

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Abstract

The invention discloses a TBJ tissue repair film type stent and a preparation method thereof. The TBJ tissue repair film type stent comprises three layers of regional structure with gradient changes:a polymer / ceramic composite material area, a polymer area and a polymer / ceramic composite material area. The preparation method comprises the following steps: firstly, obtaining the polymer film and the polymer / ceramic composite film through blending and hot-press molding, splicing the two films, carrying out hot-press fusion, and then performing axial mechanical stretching along the vertical direction of the interface of the connecting line to obtain the film type TBJ stent. The stent material is biomimics TBJ tissue in design, has multiple gradient characteristics of material component, structure and mechanical property changes, further has effects of mechanical enhancement and composite regulation of ion and mechanical signals, which is a tendon-bone repair stent material with high bionic tissue characteristics and excellent mechanical properties, and can be applied to regeneration induction and functional reconstruction of cells and extracellular matrixes in the tendon-bone junction.

Description

technical field [0001] The present invention relates to a biological material, in particular to a scaffold for tendon-to-bone junction (TBJ) repair, and also relates to a scaffold that can help damage tendon TBJ tissue constructed by ion doping and mechanical drawing The invention relates to a method for constructing a biologically adaptable material scaffold for repairing and functional regeneration, having mechanical enhancement and multi-gradient bionic features, and belongs to the technical field of medical biomaterials. Background technique [0002] Tendon injury is a common orthopedic disease at the junction of the musculoskeletal system, which mainly manifests as structural damage of TBJ acute tissue rupture and chronic lesion degeneration. In humans, the TBJ is a transitional multiphase tissue that connects tendons to bone, including fibrous connective tissue, noncalcified fibrocartilage, calcified fibrocartilage, and bone. TBJ has a typical continuous gradient stru...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/16A61L27/18A61L27/24A61L27/50A61L27/58A61F2/08
CPCA61F2/08A61L27/16A61L27/18A61L27/24A61L27/46A61L27/50A61L27/58A61L2430/02A61L2430/10
Inventor 王祖勇张皓哲吝楠马超
Owner HUNAN UNIV
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