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Macroporous adsorption resin for blood perfusion and preparation method thereof

A technology of hemoperfusion and pore adsorption, which is applied in blood circulation treatment, chemical instruments and methods, and other chemical processes, can solve the problems of lowering polymer reaction temperature, lowering reaction rate, and large adsorption capacity, so as to improve mechanical strength, Effect of reducing melt viscosity and increasing reaction rate

Active Publication Date: 2020-11-20
上海金成高分子材料有限公司
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Problems solved by technology

[0003] The adsorbent materials used for hemoperfusion mainly include activated carbon and synthetic resin. Activated carbon adsorbent has a wide range of sources and is low in cost. It has a large specific surface area and abundant pores, and can quickly absorb and remove exogenous toxins. Poor, low mechanical strength, easy to fall off, poor selectivity of adsorption and other disadvantages, synthetic resin is currently a more mature type of adsorbent for hemoperfusion, such as macroporous resin adsorbent, which utilizes a large specific surface area With large pore size and good mechanical properties, toxic substances can be adsorbed through hydrophobic interaction or grafted groups after modification, which has the advantage of large adsorption capacity
[0004] At present, most of the hemoperfusion adsorption resins used for the treatment of uremia use styrene-divinylbenzene copolymer cross-linking or divinylbenzene cross-linking to form a skeleton to adsorb related toxic substances in blood, but this limits its ability to target. Further improvement of the adsorption rate of toxic substances
The Chinese patent application with the publication number CN 105085829A discloses a method for preparing a macroporous adsorption resin for the adsorption of toxins. It first prepares a macroporous styrene-divinylbenzene resin with a relatively low degree of crosslinking, and then prepares a macroporous resin with It is an ultra-high cross-linked macroporous adsorption resin with high specific surface area and large adsorption capacity for adsorbate, and good swelling performance in organic solvents, but this preparation method discloses the use of chloromethylation reaction Preparation of chlorine balls, chloromethyl ether is a highly toxic substance, which is very harmful to human health and the environment
Publication No. CN105561950A discloses the preparation method of macroporous adsorbent resin in the Chinese patent application, which is through free radical polymerization, surface grafting step and post-crosslinking reaction. The initiator is lauryl peroxide, and the setting reaction temperature is controlled at From 45°C to 75°C, a macroporous resin with high mechanical strength, good surface gloss, excellent adsorption performance and biocompatibility was prepared. However, this method tends to increase the melt viscosity by reducing the polymer reaction temperature. As a result, the molecular weight distribution is wide, processing and molding is difficult, the reaction rate is reduced, and the adsorption rate is low, and a large amount of solvent is likely to remain in the resin pores, which is harmful to human health.

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  • Macroporous adsorption resin for blood perfusion and preparation method thereof
  • Macroporous adsorption resin for blood perfusion and preparation method thereof

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Embodiment 1

[0029] Embodiment 1 A kind of macroporous adsorbent resin for hemoperfusion

[0030] The preparation method of described macroporous adsorption resin comprises the following steps:

[0031] S1. Add 2kg of styrene, 6.5kg of divinylbenzene, 1kg of methyl acrylate, 0.01kg of gelatin derivatives, 14.25kg of toluene, 0.285kg of BPO, and 0.001kg of light magnesium oxide into the reaction kettle to form an oil phase, and stir it mechanically Add 3 times the mass fraction of the oil phase deionized water and raise the temperature to 70°C, keep the stirring speed in the reactor at 250 rpm, so that the oil phase forms uniform beads and disperses in the water phase, and keep the temperature for 2 hours Afterwards, heat up to 90°C and continue the heat preservation reaction for 4 hours to obtain polystyrene-divinylbenzene microspheres, wash them with water, dry them, and then use edible alcohol to extract toluene until clean, dry, and wet sieve to obtain a particle size of 0.3-1.5mm whit...

Embodiment 2

[0035] Embodiment 2 A kind of macroporous adsorbent resin for hemoperfusion

[0036] The preparation method of described macroporous adsorption resin comprises the following steps:

[0037] S1. Add 2.5kg of styrene, 7kg of divinylbenzene, 8kg of vinyl acetate, 0.06kg of gelatin derivatives, 10.kg of cyclohexane, 0.206kg of ABIN and 0.012kg of light magnesium oxide into the reactor to form an oil phase, Under mechanical stirring, add 1.2 times the deionized water of the mass fraction of the oil phase and heat up to 75°C, keep the stirring speed in the reactor at 300 rpm, so that the oil phase forms uniform beads and disperses in the water phase. After heat preservation reaction for 1.5 hours, heat up to 90°C and continue heat preservation reaction for 2 hours to obtain polystyrene-divinylbenzene microspheres, wash them with water, dry them, then use edible alcohol to extract toluene until clean, dry, and wet sieve Obtain white balls with a particle size of 0.3-1.5mm;

[0038] S...

Embodiment 3

[0041] Embodiment 3 A kind of macroporous adsorbent resin for hemoperfusion

[0042] The preparation method of described macroporous adsorption resin comprises the following steps:

[0043] S1. Add 2.2kg of styrene, 7.5kg of divinylbenzene, 0.001kg of TAIC triallyl isocyanurate, 0.15kg of gelatin derivatives, 0.605kg of dichloroethane, 0.087kg of BPO and light Mix 0.001kg of magnesium oxide to form an oil phase. Under mechanical stirring, add deionized water of 5 times the mass fraction of the oil phase and heat up to 70°C. Keep the stirring speed in the reactor at 250 rpm to make the oil phase uniform. The beads were dispersed in the water phase, and after 2 hours of heat preservation reaction, the temperature was raised to 90°C for 4 hours of heat preservation reaction to obtain polystyrene-divinylbenzene microspheres, which were washed with water, dried, and then extracted toluene with edible alcohol to Clean, dry, and wet sieve to obtain white balls with a particle size o...

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Abstract

The invention relates to macroporous adsorption resin for blood perfusion. A preparation method provided by the invention sequentially comprises the steps of free radical polymerization, surface grafting and post-crosslinking reaction. The macroporous adsorption resin provided by the invention is used as an adsorbent for hemoperfusion for uremia treatment, the macroporous adsorption resin for hemoperfusion comprises white balls formed by styrene monomers, polyvinyl monomers and third monomers, polyvinylpyrrolidone is grafted on the surfaces of the white balls, and the ultra-high cross-linkingmacroporous adsorption resin is formed through a post-cross-linking reaction. The preparation method is environmentally friendly, and the prepared macroporous adsorption resin for blood perfusion is low in solvent residual quantity and melt viscosity. The adsorption performance on macromolecular toxins such as parathyroid hormone and beta2-microglobulin is excellent, and the mechanical strength and biocompatibility are good.

Description

technical field [0001] The invention belongs to the technical field of hemoperfusion adsorption resin, and in particular relates to a macroporous adsorption resin for hemoperfusion and a preparation method thereof. Background technique [0002] Hemoperfusion technology is a new method that uses an adsorption detoxification device to draw the patient's blood out of the body and passes through the adsorbent with special adsorption function in the hemoperfusion device to remove endogenous and exogenous toxins in the blood, thereby improving the internal environment of the body. Blood purification technology is widely used in acute drug poisoning, uremia, and gradually expanded to severe hepatitis, hyperlipidemia, critical illness, schizophrenia, and immune system diseases. Its main mechanism is adsorption, and the adsorption material is the core of hemoperfusion technology. It is required that the adsorption material is safe and non-toxic to the human body, has high mechanical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCA61M1/36B01J20/267B01J20/28054
Inventor 王利民陶成
Owner 上海金成高分子材料有限公司
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