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A kind of surface modified titanium implant and its functional treatment method

A technology of surface functionalization and treatment method, applied in surface reaction electrolytic coating, drug delivery, pharmaceutical formulation, etc. Low, poor hydrophilicity, etc.

Active Publication Date: 2020-08-18
DABO MEDICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the low content of anatase and rutile titanium oxide, poor hydrophilicity, titanium oxide layer and hydroxyl phosphorus when the existing method is used to oxidize the surface of the titanium implant and deposit hydroxyapatite. In order to solve the defect of low bonding strength of the graystone layer, a new method for surface functionalization treatment of titanium implants and the surface modified titanium implant obtained by this method are provided. The anatase in the surface modified titanium implant is Ore and rutile have high titanium oxide content, good hydrophilicity and high bonding strength between titanium oxide layer and hydroxyapatite layer

Method used

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  • A kind of surface modified titanium implant and its functional treatment method
  • A kind of surface modified titanium implant and its functional treatment method
  • A kind of surface modified titanium implant and its functional treatment method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] S1. Degreasing: The titanium implant was ultrasonically cleaned at 60°C for 15 minutes with an oil-removing cleaning agent containing 1 wt% neutral surfactant (specifically, PWC-401 cleaning agent, the same below), to obtain a degreasing titanium implant. body.

[0037] S2. Pickling: pickling the degreasing titanium implant with a hydrofluoric acid aqueous solution with a concentration of 10 wt% at room temperature to obtain an acid-washed titanium implant.

[0038] S3, micro-arc oxidation treatment: adding sodium phosphate, potassium carbonate and ammonium molybdate into ethanol and stirring and dissolving to obtain a solution with a sodium salt concentration of 2g / L, a potassium salt solution concentration of 10g / L and an ammonium salt solution concentration of 5g / L mixture. The acid-washed titanium implant is placed in the mixed solution for micro-arc oxidation treatment at 20°C, the oxidation voltage is a gradient step voltage, the step step is 5 stages, the step o...

Embodiment 2

[0045] S1. Degreasing: The titanium implant was ultrasonically degreased and cleaned at 60° C. for 20 minutes with a degreasing agent containing 5 wt % neutral surfactant to obtain a degreased titanium implant.

[0046] S2. Pickling: pickling the degreasing titanium implant with a hydrofluoric acid aqueous solution with a concentration of 10 wt% at room temperature to obtain an acid-washed titanium implant.

[0047] S3, micro-arc oxidation treatment: adding sodium citrate, potassium sulfate and ammonium bicarbonate into ethanol and stirring and dissolving to obtain a sodium salt solution concentration of 2 g / L, a potassium salt solution concentration of 10 g / L and an ammonium salt solution concentration of 5 g / L mixed solution. The acid-washed titanium implant is placed in the mixed solution for micro-arc oxidation treatment at 30°C, the oxidation voltage is a gradient step voltage, the step step is 2 stages, the step output voltage is 500V, and the duty cycle is 15%, and the...

Embodiment 3

[0054] S1. Degreasing: The titanium implant was ultrasonically degreased and cleaned at 60° C. for 18 minutes with a degreasing agent containing 3 wt % neutral surfactant to obtain a degreased titanium implant.

[0055]S2. Pickling: pickling the degreasing titanium implant with a hydrofluoric acid aqueous solution with a concentration of 10 wt% at room temperature to obtain an acid-washed titanium implant.

[0056] S3, micro-arc oxidation treatment: add sodium edetate, potassium chloride and ammonium citrate into ethanol and stir to dissolve, to obtain a sodium salt solution concentration of 2g / L, a potassium salt solution concentration of 10g / L and an ammonium salt solution concentration It is a mixed solution of 5g / L. The acid-washed titanium implant is placed in the mixed solution for micro-arc oxidation treatment at 45°C, the oxidation voltage is a gradient step voltage, the step step is 3 stages, the step output voltage is 750V, and the duty cycle is 30%, and the oxidati...

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Abstract

The invention belongs to the field of surface treatment, and discloses a surface modified implant and a functional treatment method thereof. The functional treatment method for the titanium implant surface comprises the step (1) of placing a titanium implant in mixed solutions containing sodium salt, potassium salt and ammonium salt for micro-arc oxidation treatment, and obtaining a surface titanium oxide implant; the step (2) of cleaning the surface titanium oxide implant through picosecond or femtosecond laser for removing a loose oxide layer in a crystalline titanium oxide film, and obtaining a dense titanium oxide implant; and the step (3) of performing spray deposition treatment to the dense titanium oxide implant through nano-hydroxyapatite suspension, and performing drying, sintering and short-wave irradiation upon completion of spray deposition treatment in sequence. By adopting the method, the bonding strength between a hydroxyapatite layer and the crystalline titanium oxide film can be improved, and the obtained implant is high in hydrophilicity and biological activity, and benefits promotion of osseointegration.

Description

technical field [0001] The invention belongs to the field of surface treatment, and in particular relates to a surface-modified titanium implant and a functional treatment method thereof. Background technique [0002] At present, among the medical implant materials of medical devices, titanium and titanium alloy materials are the most widely used. Compared with other materials, titanium and titanium alloy materials have the advantages of high strength, corrosion resistance and good biocompatibility, and have been widely used in trauma, spine, neurosurgery and other internal fixation systems. However, the pure titanium and titanium alloy surface has a certain biological inertness, so more and more surface treatment methods have been used on the surface of titanium and titanium alloy, mainly by improving the biological activity, hydrophilicity, multi- Level micro-nano structure, in order to improve the osseointegration between it and the bone, promote osseointegration, and be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26A61L27/06A61L27/30A61L27/32A61L31/02A61L31/08
CPCA61L27/06A61L27/306A61L27/32A61L31/022A61L31/086A61L31/088A61L2400/18A61L2420/02A61L2420/08C25D11/026C25D11/26
Inventor 陈艳文吴健曾达林志雄陈淳淳
Owner DABO MEDICAL TECH CO LTD
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