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A kind of pharmaceutical composition, preparation and application with slimming effect

A composition and drug technology, applied in the field of medicine, can solve problems such as physical hazards, lower energy intake, and poor taste of meal replacement foods, and achieve the effect of simple formula and wide application

Active Publication Date: 2020-10-13
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs mainly contain sibutramine, orlistat and other ingredients, such as Xenical, Qumei, etc. These products mainly reduce appetite, enhance satiety, inhibit the absorption of food by the gastrointestinal tract, Promote energy consumption, increase metabolism and other ways to achieve weight loss. This type of product has strong side effects and a high rebound rate after drug withdrawal, which is harmful to the body
As for health food, through research, it is found that among the currently approved health food, there are more than 270 health food with weight loss function, and some of them have not been listed or have been eliminated in the fierce market competition shortly after listing. The number of health and weight loss products is relatively small
Weight management foods mainly exist in the form of meal replacement products, but there are very few products that can really reduce energy intake and ensure nutritional needs, and meal replacement foods often have poor taste, and it is difficult for consumer groups to persist for a long time take

Method used

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  • A kind of pharmaceutical composition, preparation and application with slimming effect
  • A kind of pharmaceutical composition, preparation and application with slimming effect
  • A kind of pharmaceutical composition, preparation and application with slimming effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Proof of the weight loss effect when the aluminum sucrose sulfate of the present invention, enteric polymer, and nano silicon dioxide are combined.

[0021] 1. Optimizing the experimental animal model by using the obesity prevention model method

[0022] Under the barrier system, all rats were fed with maintenance feed for 7 days. After the 7-day adaptation period, the rats were randomly divided into blank group and model group according to body weight. The blank group was given maintenance feed, and the model group was given high calorie. Feed rats; record the amount of food given, the amount of sprinkled food, the amount of leftover food, and record body weight every day. After feeding for 2 weeks, the rats in the model group were sorted by body weight gain, and the obesity-resistant rats with lower body weight gain were eliminated. The rats that were sensitive to obesity were selected as the experimental group. Body weight was randomly divided into test g...

Embodiment 2

[0055] Embodiment 2: powder

[0056] 1. Composition of raw materials: 60g of aluminum sucrose sulfate, 120g of hydroxypropyl cellulose phthalate, 20g of nano silicon dioxide, and 5g of gum arabic.

[0057] 2. Preparation method: Weigh sucrose aluminum sulfate, hydroxypropyl cellulose phthalate, nano silicon dioxide and gum arabic according to the composition formula of the above raw materials, sieve and mix evenly to obtain a powder.

Embodiment 3

[0058]Embodiment 3: Granules

[0059] 1. Composition of raw materials: 140g of aluminum sucrose sulfate, 40g of cellulose acetate phthalate, 20g of nano silicon dioxide, 36g of lactose, and 4g of mogroside.

[0060] 2. Preparation method:

[0061] 1) Weigh sucrose aluminum sulfate, cellulose acetate phthalate, nano silicon dioxide, lactose, and mogroside according to the above ratio, mix them evenly, and sieve.

[0062] 2) Use 60% (m / v) ethanol as a binder to obtain a soft material. The soft material is subjected to a swing granulator to obtain wet granules, and the wet granules are dried in an oven at about 50° C. to obtain granules.

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PUM

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Abstract

The invention discloses a pharmaceutical composition with an anti-obesity effect, a preparation and application thereof. The pharmaceutical composition is prepared from the following ingredients: 30 to 70 parts of saccharose aluminum sulfate, 20 to 60 parts of enteric-soluble polymer and 5 to 10 parts of nano silicon oxide. The pharmaceutical composition preparation is prepared from the pharmaceutical composition and an auxiliary material, wherein the auxiliary material is selected from a carrier of medicine or food, a diluent or a flavoring agent. The preparation is used for being prepared into powder, granules, capsules or tablets. The pharmaceutical composition disclosed by the invention has a simple formula, can synergistically reduce intestine and stomach absorption to achieve anti-obesity purpose, can be applied to weight loss of the obesity, diet control of diabetes, hyperglycemia and hyperlipidemia patients, weight loss of healthy people and the like and is suitable for peopleof all ages to take.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition, preparation and application with weight loss effect. Background technique [0002] Obesity refers to the phenomenon of obvious overweight and thick fat layer to a certain extent. It is a physiological state caused by excessive accumulation of body fat, especially triglycerides. With the improvement of people's living standards, the obesity population continues to expand, seriously affecting people's physical and mental health. Obesity is one of the risk factors for hyperglycemia and diabetes (especially type 2 diabetes), and it is also a major factor for the induction of hyperlipidemia. In addition, with the increasing pressure of life, fierce job competition, media advertisements and the improvement of aesthetic requirements, people no longer only pay attention to personal internal cultivation, but also have an urgent need to improve their exter...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61P3/10A61P3/06A23L33/10A23L33/125A23L33/16A61K31/7024A61K31/717A61K31/78
CPCA23L33/10A23L33/125A23L33/16A23V2002/00A61K31/7024A61K31/717A61K31/78A61K33/00A61P3/06A61P3/10A61K2300/00A23V2200/332A23V2200/328A23V2200/3262A23V2250/51088A23V2250/5028A23V2250/1628A23V2250/612A23V2250/254A23V2250/51084
Inventor 寇龙发陈瑞杰姚情孙锐
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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