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A degradable drug-loaded occluder, forming and unfolding method of the occluder

An occluder and drug-loading technology, which is applied in the field of medical devices, can solve the problems of non-degradable nickel-titanium-cobalt alloy wire occluders and large fluctuations in blood drug concentration, so as to avoid metal poisoning and complications, reduce pain, and avoid The effect of the attenuation of plasma drug concentration

Active Publication Date: 2021-07-16
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention is to solve the problem that the nickel-titanium-cobalt alloy wire occluder is not degradable and the blood drug concentration fluctuates greatly in the traditional way of administration, and further provides a degradable drug-loaded occluder based on fused deposition 4D printing, the occluder Forming and unfolding method

Method used

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  • A degradable drug-loaded occluder, forming and unfolding method of the occluder
  • A degradable drug-loaded occluder, forming and unfolding method of the occluder
  • A degradable drug-loaded occluder, forming and unfolding method of the occluder

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Experimental program
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Effect test

Embodiment 1

[0066] Such as Figure 2-Figure 4 and Figure 6 Shown is a schematic diagram of the unfolded state of the degradable drug-loaded occluder based on fused deposition 4D printing. The support structure of the occluder is a degradable shape memory polymer, which is petal-shaped and double-disc thin-waisted structure, and its surface has a micro-nano structure that can be loaded with drugs 2-1, such as Figure 6 shown. Before implantation, the support structure 2 is immersed in the medical solution that is beneficial to the patient's recovery in the early stage after the operation, and the micro-nano structure 2 automatically loads the drug, and the concentration of the drug is controlled according to the concentration of the drug solution.

Embodiment 2

[0068] The support structure 2 is a degradable shape-memory polymer, including a mixture of one or more of shape-memory polylactic acid, shape-memory polycaprolactone, shape-memory chitosan, and shape-memory polyurethane; its glass transition temperature is 38 In the range of -50°C, the driving method is one or more of thermal driving, solution driving and magnetic driving. The polymer is mixed with ferric oxide and developer, and the developer includes barium sulfate, metal tantalum, molybdenum target, diatrizoate meglumine, iohexol or iotaramic acid, and the developer is in It plays a positioning function during the delivery and deployment of the occluder. At the same time, the polymer also contains drugs that are beneficial to the patient during the rehabilitation stage, including cefuroxime, ankexin, clindamycin, amoxicillin, piperacillin, One or more mixtures of penicillin sodium.

[0069] It can be configured according to the following components in terms of mass percen...

Embodiment 3

[0071] A 4D printing-based developable and degradable drug-loaded occluder unfolds and collapses as follows:

[0072] The drive mode is magnetic drive

[0073] 1. Heating the occluder in the expanded state to above the glass transition temperature of the shape-memory polymer of the support structure; the occluder includes the following components: a mixture of ferroferric oxide and shape-memory polymer and a flow-blocking membrane ;

[0074] 2. Apply an axial pulling force to the occluder until the occluder is in a closed state, maintain the load and quickly cool down to below the glass transition temperature of the shape memory polymer used, and fix the closed state;

[0075] 3. Put the occluder in the collapsed state into the delivery sheath, and send the head of the sheath to the defect;

[0076] 4. The sheath is connected to the air pump, and when it reaches the defect site, the air pump will push the occluder out of the sheath;

[0077] 5. A local magnetic field is app...

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Abstract

A degradable drug-loaded occluder and a method for forming and unfolding the occluder, which relate to the field of medical devices, to solve the problem that the nickel-titanium-cobalt alloy wire occluder is not degradable and the blood drug concentration fluctuates greatly in the traditional administration method , it is mainly composed of a support structure and a choke film; the support structure is a mesh structure with double disks, and the choke film is packaged and covered on the two disks. Forming method: one, through computer-aided design, import the format file containing the degradable drug-loaded occluder into the 3D printer; two, send the prepared shape-memory polymer filament into the printing material port through the guide wire device; three, The printing nozzle melts the polymer filament and extrudes the nozzle; 4. The extruded shape memory polymer is rapidly cooled on the printing table and piled up layer by layer to complete the structural formation of the degradable support structure; 5. The flow blocking film is covered on the support On the two disk surfaces of the structure, the preparation of the degradable drug-loaded occluder is completed. The occluder of the present invention also has the degradable function of drug-loaded shape memory.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a degradable drug-loaded occluder based on fused deposition 4D printing. Background technique [0002] Congenital heart disease (CHD) is the most common birth defect disease, among which atrial septal defect (ASD), patent foramen ovale (PFO) and ventricular septal defect (VSD) account for more than 50% of the total number of CHD. [0003] Interventional therapy uses femoral vein puncture, and the delivery system sends the occluder to the heart defect site, which has the advantages of targeted therapy and minimally invasive. [0004] Shape memory polymers are an important branch of smart materials, which can sense external stimuli and realize the transformation between temporary and permanent shapes. [0005] 3D printing technology belongs to the field of additive manufacturing. Fused deposition printing technology (FDM) is one of the most commonly used 3D printing technologies at ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B17/00B29C64/118B33Y10/00
CPCA61B17/0057A61B2017/00526A61B2017/00575A61B2017/00623A61B2017/00831A61B2017/00867B33Y10/00B29C64/118
Inventor 冷劲松刘立武林程辛晓洲刘彦菊
Owner HARBIN INST OF TECH
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