Bionic biomineralized artificial bone repair material as well as preparation method and application thereof

Abstract

The invention provides a bionic biomineralized artificial bone repair material as well as a preparation method and an application thereof. The material consists of a cross-linked collagen matrix and biomineralized collagen / hydroxyapatite composite powder dispersed in the matrix, wherein the mass ratio of the collagen matrix to the biomineralized collagen / hydroxyapatite composite powder is (9-1) to(1-9). The bionic biomineralized artificial bone repair material provided by the invention is a collage-based bionic biomineralized artificial bone, which can meet a demand of artificial bone and tissue suturing in a clinical GTR or GBR operation; the artificial bone repair material consists of hydroxyapatite and pure collagen, and the two ingredients are major ingredients of human natural tissues, so that the artificial bone repair material is free from toxicity; and influence to a material structure and an osteogenesis effect is avoided, and good biocompatibility is guaranteed. Due to the existence of the cross-linked collagen matrix, problems of a material which can get dispersed easily, and is too high in degradation speed, poor in mechanical performance and the like can be solved; and the bionic construction of nano-hydroxyapatite and collagen is achieved.

Description

technical field [0001] The invention relates to a bionic biomineralized artificial bone and a preparation method and application thereof, belonging to the field of biomedical materials. Background technique [0002] Clinically, bone defects are mainly caused by trauma, infection, and tumors. In response to this situation, people have prepared a variety of substitute materials for bone repair through various methods or approaches, and achieved certain results. [0003] Bone implant materials can be roughly divided into autologous bone, allograft bone, xenograft bone, and synthetic materials. Autologous bone transplantation is rarely used due to the limitation of its own donors; although the bone formation effect of allograft bone is better, it also has the risk of rejection and virus infection, and because of limited sources, it is difficult to achieve a large number of patients in clinical practice. Use; Xenograft bone is rarely used due to the large rejection reaction. Th...

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Problems solved by technology

[0005] The research on bone scaffolds at home and abroad mainly focuses on the composite scaffolds of hydroxyapatite and collagen. Although CN1562387A, CN101229392A, CN101417145A, etc. have produced various types of collagen / hydroxyapatite composite bone scaffolds, due to the existence of such materials Loose structure, relatively poor strength, very weak toughness, too fast degradation rate, etc., can not match the bone growth rate well, making it difficult to become a good scaffold for bone tissue engineering

Existing studies have shown that the spatial structure of three-dimensional scaffolds is the basis of bone repair materials and bone conduction properties. performance of composite materials, but there are still problems such as high brittleness, scattered orientation of hydroxyapatite microcrystals, and poor bonding with collagen. Moreover, these scaffolds are formed by compaction, and no porous structure is formed. Morphology, which is not conducive to cell adhesion and proliferation

CN102205150A, CN103785059A, and CN102240415A use polylactic acid or its copolymers as the matrix to prepare bone materials with a three-dimensional void structure. Although they have good mechanical properties, the hydrophilic properties of the materials are poor, and the degradation products will continue to produce acidic substances, causing poor biocompatibility

CN105457097A, CN101554493A use the anti-collapse agent, dispersant and / or modifier etc. to fully mix to obtain nano-hydroxyapatite / collagen scaffold, but the anti-collapse agent, dispersant and / or modifier etc. in the scaffold are non-natural Components of bone structure, affecting material structure and osteogenesis

[0006] In summary, the field needs a three-dimensional bone repair scaffold material with good bionic effects, but it has not been effectively satisfied for a long time. Therefore, it is urgent to develop a new bone repair scaffold material to meet the actual needs

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