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A nanomaterial for magnetic resonance imaging and/or photothermal therapy and preparation method thereof

A technology of magnetic resonance imaging and nanomaterials, applied in preparations for in vivo experiments, wave energy or particle radiation treatment materials, medical preparations containing active ingredients, etc., can solve high osmotic pressure, short retention time, non-toxic Tissue and organ selectivity and targeting, etc., to achieve the effects of targeting, less toxic and side effects, good contrast effect, and long circulation time in the body

Active Publication Date: 2020-05-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the contrast agent commonly used in clinical practice, such as gadolinium diethylenetriaminepentaacetate (Gd-DTPA), is a small molecule ionic contrast agent. Due to its high osmotic pressure in the body, it is easily eliminated after renal metabolism, and it remains in the body for a long time. Short, no selectivity and targeting of tissues and organs

Method used

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  • A nanomaterial for magnetic resonance imaging and/or photothermal therapy and preparation method thereof
  • A nanomaterial for magnetic resonance imaging and/or photothermal therapy and preparation method thereof
  • A nanomaterial for magnetic resonance imaging and/or photothermal therapy and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Preparation of nanomaterials

[0044] (1) Add mPEG-DA (131.09mg; 2eq), DTPA(HTA) to 25mL deionized water 2 @Gd (25mg; 1eq), CuSO 4 ·5H 2 O (125mg), make Cu in the system 2+ The concentration was 20mM, and reacted at 80°C for 5h.

[0045] (2) Dialysis (Mw=2000) for 72 hours.

[0046] (3) freeze-drying.

[0047] 2. Performance analysis of nanomaterials

[0048] Such as figure 1 As shown, the volume average particle diameter of the nanomaterial measured by dynamic light scattering (DLS) is 115 nm (distribution coefficient PDI=0.235).

[0049] Such as figure 2 As shown, the particle size of nanomaterials observed by transmission electron microscopy (TEM) is 100nm, which is consistent with the particle size results measured by DLS.

[0050] Such as image 3 As shown, the R1 value of Magnevist was determined to be 4.3mM -1 ·s -1 , consistent with the literature. The nanomaterial has a gadolinium content of 4% and a relaxation rate R1 value of 9.55mM -1 ·s -...

Embodiment 2

[0060] Nanomaterials were prepared according to the reaction conditions in Table 1, and the process flow was referred to in Example 1. Table 1 shows the particle size results of the obtained products.

[0061] Table 1

[0062]

[0063]

[0064] A: Dopamine modified DTPA-Gd

[0065] B: Dopamine-modified PEG

[0066] It can be seen from the above table that when the copper ion concentration is greater than 40 mM or less than 10 mM, the size of the nanomaterials is too large. Particles that are too large cannot be enriched in tumor tissue through the EPR effect, and are easily trapped by the reticuloendothelial system. Therefore, they are not suitable for use as the magnetic resonance imaging contrast agent and photothermal therapy agent of the present invention.

[0067] If the heating temperature exceeds 90°C, the prepared nanomaterials will have the problem of non-uniform particle size, which will affect their use effect.

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Abstract

The invention discloses a nanometer material for magnetic resonance imaging and / or photo-thermal treatment and a preparation method thereof and belongs to the field of diagnosis and treatment integration of photo-thermal treatment mediated by the magnetic resonance imaging. The preparation method for the nanometer material comprises the following steps: partially oxidizing catechol into semiquinone or quinone with high activity under the effect of cupric ions under the heating condition of dopamine modified gadolinium compound and dopamine modified polyethylene glycol in an aqueous medium, and then agglomerating the product, thereby acquiring the nanometer material. According to the invention, a micromolecular gadolinium contrast agent is transformed into a macromolecular gadolinium contrast agent through oxidative coupling reaction; the macromolecular gadolinium contrast agent has the advantages of high relaxation efficiency, long in vivo cycling time, low targeting and toxic or side effect, and the like; the nanometer material prepared according to the invention has higher photo-thermal conversion efficiency in a near-infrared area and can be used as a photo-thermal treatment agent in the photo-thermal treatment; and a magnetic resonance technique can be utilized to confirm the position and size of the tumor and the enrichment condition of the photo-thermal treatment agent in the tumor tissue and can be used for evaluating the treatment effect.

Description

technical field [0001] The invention relates to the field of integrated diagnosis and treatment of photothermal therapy mediated by magnetic resonance imaging, in particular to a nanometer material for magnetic resonance imaging and / or photothermal therapy and a preparation method thereof. Background technique [0002] Photothermal therapy (PTT) is a treatment method that uses materials with high photothermal conversion efficiency to convert light energy into heat energy under near-infrared light conditions, resulting in local high temperature of tumor cells, thereby killing cancer cells. In the past few years, a variety of nanomaterials with strong near-infrared absorption, including various gold nanoparticles, carbon nanomaterials, palladium flakes, copper sulfide nanoparticles, and even some organic nanoparticles, have been used as photothermal reagents. For photothermal therapy of tumors. Since water and protein in biological tissues absorb near-infrared light relativel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/12A61K41/00A61P35/00
CPCA61K41/0052A61K49/085A61K49/128
Inventor 唐建斌夏明春申有青刘祥瑞周珠贤
Owner ZHEJIANG UNIV
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