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Composition capable of protecting liver

A composition and liver technology, applied in the field of medicine, can solve the problems of transaminase rebound, blood pressure rise, etc., and achieve the effects of reducing damage, good anti-oxidation, and protecting the liver

Inactive Publication Date: 2017-05-24
BEIJING FUNAKANG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Most of the drugs in the prior art cannot avoid side effects after medication, such as: after taking bifendate, there may be reactions such as dry mouth, nausea, rash, etc., and the phenomenon of transaminase rebound after stopping the drug; May cause chest tightness, edema, mild blood pressure increase, etc.

Method used

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  • Composition capable of protecting liver
  • Composition capable of protecting liver
  • Composition capable of protecting liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1. Preparation of the composition

[0060] 0.6g fullerene C60, 1g vitamin E, 0.1g coenzyme Q10, 0.05g astaxanthin, 0.006g tea polyphenols, 0.03g curcumin, and 0.005g lycopene were evenly dispersed in 99.0ml olive oil to obtain Composition 1.

[0061] 2. Subjects

[0062] 70 6-week-old ICR mice were randomly divided into 7 groups on average, namely composition 1+normal saline group, olive oil+normal saline group, bifendate+normal saline group, composition 1+CCl 4 Group, olive oil+CCl 4 Group, Bifendate+CCl 4 group and water+CCl 4 Group.

[0063] 3. Experimental method

[0064] Composition 1+physiological saline group: intragastric administration of composition 1 at a dosage of 5ml / kg for 2 consecutive weeks; intraperitoneal injection of mice after 2 weeks of intragastric administration of composition 1 Physiological saline, the injection dose is 1ml / kg, put to death mice after 16h and do the detection of SOD (superoxide dismutase) and ALT (alanine aminotransferase...

Embodiment 2

[0077] 1. Preparation of the composition

[0078] 0.3g fullerene C60, 3g vitamin E, 0.07g astaxanthin, 0.3g coenzyme Q10, 0.006g tea polyphenols, 0.005g lycopene, 0.01g soybean isoflavones and 0.05g ganoderma lucidum spore oil were evenly dispersed in 99.0 ml of linseed oil, composition 2 is obtained.

[0079] 2. Subjects

[0080] 70 6-week-old ICR mice were randomly divided into 7 groups on average, namely composition 2+normal saline group, linseed oil+normal saline group, bifendate+normal saline group, composition 2+CCl 4 Group, linseed oil+CCl 4 Group, Bifendate+CCl 4 group and water+CCl 4 Group.

[0081] 3. Experimental method

[0082] Using a method similar to Example 1, only make adaptive changes to the added substances, that is: composition 2+physiological saline group and composition 2+CCl 4 Composition 2 was used in the group, and other conditions were unchanged; linseed oil+normal saline group and linseed oil+CCl 4 Linseed oil was used in the group, and the r...

Embodiment 3

[0088] 1. Preparation of the composition

[0089] Mix 0.5g fullerene C60, 2g vitamin E, 0.06g astaxanthin, 0.4g coenzyme Q10, 0.01g anthocyanin, 0.01g curcumin, 0.05g ganoderma lucidum polysaccharide, 0.02g soybean sterol and 0.01g β-carotene Composition 3 is obtained by dispersing in 99 ml of Prickly Pear Oil.

[0090] 2. Subjects

[0091] 70 6-week-old ICR mice were randomly divided into 7 groups on average, namely the composition 3+normal saline group, the green thorn fruit oil+normal saline group, the bifendate+normal saline group, and the composition 3+normal saline group. CCl 4 Group, green thorn fruit oil+CCl 4 Group, Bifendate+CCl 4 group and water+CCl 4 Group.

[0092] 3. Experimental method

[0093] Using a method similar to Example 1, only make adaptive changes to the added substances, that is: composition 3+physiological saline group and composition 3+CCl 4 Composition 3 was used in the group, and all the other conditions were unchanged; 4 What used in the...

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PUM

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Abstract

The invention discloses a composition capable of protecting liver. The composition comprises fullerene evenly dispersed in edible oil, and further comprises at least one of vitamin C, vitamin E, catechinic acid, alpha-lipoic acid, anthocyanin, curcumin, carotenoid, plant polyphenolses, plant polysaccharides, animal and plant terpene, plant flavonoid, SOD (Superoxide Dismutase), coenzyme Q10, glutathione, lactoferrin and metallothionein evenly dispersed in the edible oil. The composition effectively protects the liver and reduces the damage of the negative factor on the mouse liver, so that the blood index of the liver function tends to be at the normal range, the excellent effect of scavenging a free radical is achieved, the liver is cleared, and the redox state of the liver is improved.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composition for protecting the liver. Background technique [0002] The liver is an important organ to maintain the body's life activities. It not only participates in various biochemical processes such as digestion, excretion, detoxification, synthesis, and immunity, but also plays a vital role in the metabolism of carbohydrates, proteins, and fats in the body. The liver is the main organ that metabolizes toxic substances in the body. Once a large amount of toxic chemical substances are ingested in a short period of time beyond the tolerance of the liver, it will cause acute and chronic liver damage to the liver. The specific manifestations of liver injury include destruction of liver cell structure, obvious deformation of liver cell shape, cell infiltration, and obvious decrease in the number of nuclei, as well as increased activity of alanine aminotransferase (ALT) and decreased cont...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61K36/074A61K36/87A61K47/44A61P1/16A23L33/115A23L33/15A23L33/10A23L33/125A23L33/11A23L33/17A23L33/18A61K31/355A61K31/122A61K31/353A61K31/12A61K31/01A61K31/352A61K31/715A61K31/575A61K31/015A61K31/704
CPCA61K33/44A23V2002/00A61K31/01A61K31/015A61K31/12A61K31/122A61K31/352A61K31/353A61K31/355A61K31/575A61K31/704A61K31/715A61K36/074A61K36/87A61K47/44A61K2300/00A23V2200/30
Inventor 王春儒李慧付笑彦
Owner BEIJING FUNAKANG BIOTECH CO LTD
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