Novel lamellar molybdenum disulfide-based nano-immune adjuvant and its preparation method and application
A molybdenum disulfide, immune adjuvant technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, antibody medical ingredients, etc. Toxicity, enhanced immune response, increased secretion levels
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Embodiment 1
[0064] A. Preparation of molybdenum disulfide nanosheets
[0065] (1) Weigh 500mg of molybdenum disulfide powder (99%) and place it in a 10mL dry round-bottomed flask, feed nitrogen, add 5mL of 1.6mol / L n-butyllithium dispersed in hexane, and react at room temperature for 48h;
[0066] (2) After the reaction is over, add hexane, dilute the reaction solution, and centrifuge for 10 min; disperse the lower layer of sediment with hexane, and centrifuge twice;
[0067] (3) Take the lower layer of precipitate and disperse it in aqueous solution, sonicate until no bubbles are generated; centrifuge for 10 minutes, remove the lower layer, take the supernatant, and dialyze with a dialysis membrane with a molecular cut-off of 14kDa for 48 hours to obtain molybdenum disulfide nanosheets with less than 10 sheets aqueous solution.
[0068] B. Preparation of molybdenum disulfide-based nano-immune adjuvant with small particle size and uniform size
[0069] (1) Ultrasonically operate the mol...
Embodiment 2
[0084] A. Preparation of molybdenum disulfide nanosheets
[0085] (1) Weigh 500mg of molybdenum disulfide powder (99%) and place it in a 10mL dry round-bottomed flask, feed nitrogen, add 5mL of 1.6mol / L n-butyllithium dispersed in hexane, and react at room temperature for 48h;
[0086] (2) After the reaction is over, add hexane, dilute the reaction solution, and centrifuge for 10 min; disperse the lower layer of sediment with hexane, and centrifuge twice;
[0087] (3) Take the lower layer of precipitate and disperse it in aqueous solution, sonicate until no bubbles are generated; centrifuge for 10 minutes, remove the lower layer, take the supernatant, and dialyze with a dialysis membrane with a molecular cut-off of 14kDa for 48 hours to obtain molybdenum disulfide nanosheets with less than 10 sheets aqueous solution.
[0088] B. Preparation of molybdenum disulfide-based nano-immune adjuvant with small particle size and uniform size
[0089] (1) Ultrasonically operate the mol...
Embodiment 3
[0104] A. Preparation of molybdenum disulfide nanosheets
[0105] (1) Weigh 500mg of molybdenum disulfide powder (99%) and place it in a 10mL dry round-bottomed flask, feed nitrogen, add 5mL of 1.6mol / L n-butyllithium dispersed in hexane, and react at room temperature for 48h;
[0106] (2) After the reaction is over, add hexane, dilute the reaction solution, and centrifuge for 10 min; disperse the lower layer of sediment with hexane, and centrifuge twice;
[0107] (3) Take the lower layer of precipitate and disperse it in aqueous solution, sonicate until no bubbles are generated; centrifuge for 10 minutes, remove the lower layer, take the supernatant, and dialyze with a dialysis membrane with a molecular cut-off of 14kDa for 48 hours to obtain molybdenum disulfide nanosheets with less than 10 sheets aqueous solution.
[0108] B. Preparation of molybdenum disulfide-based nano-immune adjuvant with small particle size and uniform size
[0109] (1) Ultrasonically operate the mol...
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