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Hip prosthesis handle surface nanometer biological active coating and preparing method thereof

A hip joint prosthesis, bioactive technology, applied in coating, prosthesis, metal material coating process, etc., can solve the problems of artificial hip joint handle and surrounding bone tissue not firm, overflowing, easy to loosen, etc. , to achieve the effect of improving biological activity and biocompatibility, improving reliability and improving adhesion

Active Publication Date: 2016-07-20
CHINA UNIV OF MINING & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a nano bioactive coating on the surface of the hip joint prosthesis handle with shielding ion release ability, excellent biological activity and good adhesion and its preparation method, to solve the problem of artificial hip joint handle made of Ti6Al4V alloy. The surrounding bone tissue is not firmly combined, and it is prone to loosening and overflow of harmful aluminum and vanadium ions after surgery

Method used

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  • Hip prosthesis handle surface nanometer biological active coating and preparing method thereof
  • Hip prosthesis handle surface nanometer biological active coating and preparing method thereof

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preparation example Construction

[0029] The preparation method of nano-bioactive coating: the multi-component nano-gradient composite coating on the surface of the artificial hip joint is prepared by a multi-target magnetron sputtering surface functional thin film deposition system, and the sputtering process ensures that the vacuum degree of the cavity body reaches 1-5× 10 -5 Between Pa, the target-base distance is adjusted within the range of 60-100mm, and the rotation speed of the base frame is adjusted within the range of 5-10r / min, including the following steps in turn:

[0030] ①Substrate pretreatment: Grind and polish the Ti6Al4V substrate with sandpaper. After the surface roughness meets the requirements, clean it in acetone and ethanol solutions for 10-15 minutes respectively; Perform acid etching and activation treatment on the surface of the mixed solution, heat the mixed solution in a water bath to 70°C, and keep it warm for 30 minutes, then ultrasonically clean the activated substrate again, and ...

Embodiment 1

[0037] Example 1: figure 1 The middle coat is only distributed in the proximal 1 / 2-2 / 3 of the articular handle.

[0038] (1) After the polished Ti6Al4V substrate is ultrasonically cleaned, it is placed in a mixture of sulfuric acid (66.3%) and hydrochloric acid (10.6%) with a mass percentage of 1:1 and heated to 70°C in a water bath, and it is kept for 30 minutes for acid etching and activation treatment , ultrasonically clean the acid-etched substrate, and dry it in a drying oven for later use;

[0039] (2) Adjust the target-base distance to 60mm, and evacuate until the vacuum degree of the cavity body reaches 2×10 -5 Pa, argon gas is introduced, the flow rate of argon gas is 120sscm, the discharge pressure is 1.0Pa, the bias power is adjusted to -500V, the pollutants on the surface of the substrate and the inner wall of the cavity are cleaned and the surface is activated for 15 minutes;

[0040] (3) Adjust the argon gas flow rate to 100sscm, keep the discharge pressure unc...

Embodiment 2

[0046] (1) Put the polished Ti6Al4V substrate in acetone and alcohol for ultrasonic cleaning for 15 minutes each, and dry it in a drying oven for later use;

[0047] (2) Adjust the target-base distance to 80mm, and evacuate until the vacuum degree of the cavity body reaches 1×10 -5 Pa, argon gas is introduced, the flow rate of argon gas is 100sscm, the discharge pressure is 1.0Pa, the bias power is adjusted to -800V, the substrate surface and the inner wall of the cavity are cleaned and the surface is activated for 15 minutes;

[0048](3) Adjust the discharge pressure to 0.8Pa, keep the argon gas flow constant, turn off the bias power supply, adjust the intermediate frequency power supply current 1A to clean the titanium target, the DC power supply current 1A to clean the silicon target, the RF power supply Ⅰ power 300W to clean the ceramic target, and the RF power supply Ⅱ Power 300W to clean the composite target of HA and bioactive glass, and clean the pollutants on the surf...

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Abstract

The invention relates to a hip prosthesis handle surface nanometer biological active coating and a preparing method thereof. The hip prosthesis handle surface nanometer biological active coating is characterized in that a joint handle surface is sequentially formed by a Ti6Al4V matrix (1), a metal Ti layer (2), a metal Ti and compact ceramic mixing layer (3), a compact ceramic layer (4), a compact ceramic and BAG / HA / Si mixing layer (5) and a BAG / HA / Si multi-element biological active layer (6). A non-equilibrium magnetic sputtering technology is adopted for sequential deposition of a multifunctional nanometer gradient composite coating with continuously-changed ingredients. The coating prepared from the method has the good biological activity, the good biocompatibility and the good membrane-matrix bonding strength, and BAG and HA are compounded so that the degradation speed of the coating can be regulated and controlled to be closer to the human tissue; a compact transition layer can effectively prevent releasing of harmful metal ions; and Si is a catalyst for converting BAG to apatite and plays an important role in initial bone calcification. By means of the hip prosthesis handle surface nanometer biological active coating and the preparing method, the bonding strength of the prosthesis handle and the surface coating can be improved, firm chemical bonding with the human bone tissue can be formed, releasing of the harmful metal ions is reduced, and the using reliability of the prosthesis handle is improved.

Description

technical field [0001] The invention relates to an artificial hip joint surface coating and a preparation method thereof, in particular to a nano bioactive coating on the surface of a hip joint prosthesis handle and a preparation method thereof. Background technique [0002] Ti6Al4V alloy is a commonly used artificial joint prosthesis material. The artificial hip joint prosthesis uses Ti6Al4V alloy as the surface of the joint handle coated with nano-bioactive gradient coating. [0003] Since the study of biological oxide coating was first reported abroad in 1931, surface modification technology and coating types have been continuously enriched and developed. On the one hand, the most studied and widely used hydroxyapatite (HA) coating has good bioactivity and biocompatibility. However, when it is coated on the surface of Ti6Al4V alloy, the thermal expansion coefficient of the substrate and HA is quite different. Therefore, the coating is easy to peel off, and the degradatio...

Claims

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Application Information

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IPC IPC(8): C23C14/35C23C14/16C23C14/08C23C14/10C23C14/02C23C14/58A61L27/32A61L27/30
CPCA61L27/306A61L27/32A61L2420/08C23C14/02C23C14/021C23C14/022C23C14/0635C23C14/0641C23C14/0664C23C14/082C23C14/10C23C14/165C23C14/352C23C14/5806
Inventor 亓健伟贺丹枫王庆良陈章波
Owner CHINA UNIV OF MINING & TECH
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