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Styptic powder

A technology of hemostatic powder and calcium polyglutamate, applied in the field of hemostatic powder, can solve problems such as poor batch stability and difficult quality control, and achieve the effects of controllable structure, good biocompatibility, and easy quality control

Inactive Publication Date: 2015-10-28
青岛卫辽医用生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these absorbable hemostatic powders are obtained from plant-extracted natural polysaccharides, modified and processed, avoiding animal sources, and the safety is better guaranteed, but because they are natural polysaccharide products, there are still poor batch stability and quality control problems in production. difficulties and other issues; in addition, its hemostatic performance needs to be further improved

Method used

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  • Styptic powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prepare 100 mL of an aqueous solution containing 0.2 g calcium polyglutamate and 0.2 g adipic dihydrazide as the water phase; use n-heptane as the oil phase medium, add emulsifier / oil phase = 1 / 100 (w / w) After the emulsifier Tween80 is mixed evenly, the water-oil two-phase mixture is emulsified evenly according to the water / oil ratio=1:4 (v / v). Add 4 mL of aqueous solution containing 0.24 g EDAC and 1 mL of 0.1 mol / L hydrochloric acid in sequence, stir for 6 hours, add 400 mL of water, centrifuge, wash thoroughly with isopropanol, and dry in vacuum to obtain adipic acid dihydrazide cross-linked polyglutamic acid Calcium hemostatic powder, its scanning electron microscope photo is as follows figure 1 shown.

Embodiment 2

[0028] Prepare 100 mL of an aqueous solution containing 0.4 g of calcium polyglutamate and 0.2 g of adipate dihydrazide as the water phase; use cyclohexane as the oil phase medium, and add emulsifier / oil phase = 1 / 100 (w / w) After the emulsifier Tween80 is mixed evenly, the water-oil two-phase mixture is emulsified evenly according to the water / oil ratio=1:4 (v / v). Add 4 mL of aqueous solution containing 0.24 g EDAC and 0.1 mL of 0.1 mol / L hydrochloric acid in sequence, stir for 24 hours, add 200 mL of isopropanol, centrifuge, wash thoroughly with isopropanol, and dry in vacuo to obtain adipic acid dihydrazide cross-linked polymer Calcium glutamate hemostatic powder.

Embodiment 3

[0030] Hemostatic performance evaluation test of cross-linked polycalcium glutamate-based hemostatic powder. Establish rat femoral artery hemorrhage model, respectively evaluate and compare cross-linked polyglutamate calcium-based hemostatic powder 1 (prepared in Example 1), cross-linked polyglutamate calcium-based hemostatic powder 2 (prepared in embodiment 2) and Yunnan Baiyao (control group) hemostatic effect. Select 48 SD rats (body weight: 200 ± 20 g), half male and half female, and randomly divided into 4 groups, 12 rats in each group, half male and half male. The 4 groups are respectively: cross-linked calcium polyglutamate-based hemostatic powder 1 (prepared in Example 1), cross-linked polyglutamate calcium-based hemostatic powder 2 (prepared in Example 2), Yunnan Baiyao (control group) and gauze (blank group). The hemostatic powder of the experimental group and the control group was added at a dose of 0.1 g. All animals were anesthetized by intraperitoneal injectio...

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Abstract

The invention aims to provide a crosslinking poly glutamic acid calcium microsphere. The adopted base material poly glutamic acid is a polyamino acid material obtained through microorganism fermentation synthesis, controllable in structure, biodegradable, excellent in biocompatibility, simple in product forming technology and easy to control in quality; in addition, the hemostasis process of the crosslinking poly glutamic acid calcium microsphere is not affected by normal clotting mechanism and can still play the stypticity for patients using an anticoagulant and with low blood platelets and complete blood cells; release of Ca <2+> in the material can accelerate activation of intrinsic coagulation factors to realize the auxiliary stypticity; moreover, poly glutamic acid has better biological adhesiveness, facilitates control of continuous errhysis of tissues, and is higher in hemostasis capacity.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a hemostatic powder. Background technique [0002] In many cases, injury or uncontrolled bleeding after surgery is the leading cause of death. In various surgical operations, absorbable hemostatic materials can directly reduce blood loss in the body to effectively maintain blood volume, avoid adverse reactions caused by the use of systemic coagulation drugs, reduce blood transfusion and operation time; reduce postoperative exudation and complications Therefore, it has been highly valued by the medical and industrial circles of various countries. Common hemostatic materials come in a variety of dosage forms, including sponges, films, micropowders, gels, etc. The fields of application of different dosage forms of hemostatic materials are also different. [0003] Absorbable hemostatic powder is a new type of hemostatic material developed in recent years. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/42A61L15/64
Inventor 曾戎项金荣崔海栋
Owner 青岛卫辽医用生物材料有限公司
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