Diacerein injection type thermo-sensitive gel and method for preparing same
A temperature-sensitive gel and diacerein technology, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of slow onset of action, and achieve easy-to-control dosage and simple operation , The effect of simple preparation process
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Embodiment 1
[0036] The preparation of embodiment 1 thermosensitive gel solution
[0037] The drug-containing thermosensitive gel solution and the blank thermosensitive gel solution were prepared by cold melting method.
[0038] Preparation of blank gel solution: Swell an appropriate amount of HPMC with deionized water to form a solution, sprinkle precisely weighed poloxamer evenly on the surface of the mixture, and then refrigerate at 4°C overnight to make it slowly and fully swell And after dissolving, a clear, lump-free, uniformly dispersed blank thermosensitive gel solution was obtained for future use.
[0039] Preparation of the drug-containing gel solution: Diacerein powder plus a small amount of DMSO is fully mixed and uniform, and the solution is left to stand until the solution is clarified, and then added to a blank gel solution to prepare a drug-containing thermosensitive gel solution.
Embodiment 2
[0040] The investigation of embodiment 2 thermosensitive gelling temperature
[0041] The temperature-sensitive gelling temperature was measured by the test tube inversion method.
[0042] Put 2mL of temperature-sensitive gel solution into a graduated test tube, and insert a precision thermometer with an accuracy of 0.1°C into a constant temperature water bath to keep the test tube water bath environment stable, and the gel heated evenly to ensure accurate measurement results. The mercury bulb of the thermometer is completely submerged below the water surface. Set the initial temperature of the water bath to 25°C, take out the test tube and turn it over every time the temperature rises by 0.5°C, and observe the gelation situation, until the gel solution solidifies, read the scale value of the thermometer immediately, this temperature is the gelation temperature, each sample Parallel measurement was performed 3 times, and the results were averaged. Compared with the magnetic ...
Embodiment 3
[0043] Embodiment 3 thermosensitive gel prescription screening
[0044] Effects of P-407 and P188 on Gel Temperature
[0045] P407 and P188 were prepared in different concentration ratios according to the cold melting method of Example 1 to prepare a temperature-sensitive gel solution, and the temperature-sensitive gelling temperature was measured by the test tube inversion method in Example 2. The specific results are shown in Table 1.
[0046] Table 1 Effect of different concentration ratios of P407 and P188 on gelation temperature
[0047]
[0048]
[0049] It can be seen from Table 1 that the different concentration ratios of P407 and P188 have a great influence on the temperature-sensitive gel phase transition temperature. Within a certain range, the temperature-sensitive gel temperature decreases with the increase of the concentration of P407, and increases with the increase of the concentration of P188. . It can be seen from Table 1 that the gelling temperature...
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