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Nanoscale emulsion with high transdermal absorbency

A nano-emulsion, absorbent technology, applied in the directions of emulsion delivery, skin care preparations, skin diseases, etc., can solve the problems of unstable properties of nano-emulsion, improve transdermal absorption capacity, good stability, increase lipid Soluble effect

Inactive Publication Date: 2015-04-22
AESTHETIC TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the main component in the Rhodiola rosea extract is salidroside, the extract also contains other components, resulting in unstable properties of the nanoemulsion provided by the invention

Method used

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  • Nanoscale emulsion with high transdermal absorbency
  • Nanoscale emulsion with high transdermal absorbency
  • Nanoscale emulsion with high transdermal absorbency

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Nanoscale emulsion with high transdermal absorption

[0034] 1. Composition:

[0035]

[0036] 2. Preparation method:

[0037] 1) Dissolve phospholipids in 70ml of chloroform-n-hexane solution (chloroform:n-hexane, 5:7, v / v), and dissolve salidroside in 10ml of distilled water. After stirring evenly, mix the two solutions and ultrasonicate , the obtained emulsion is freeze-dried to obtain the salidroside-phospholipid complex;

[0038] 2) Salidroside-phospholipid complex, caprylic acid / capric glyceride, polyglycerol monooleate, Tween 80, polyoxyethylene castor oil, polyethylene glycol caprylic acid / capric glyceride are mixed, at 8000rpm Under high-speed shearing conditions, until there is no visible solid in the system;

[0039] 3) Glycerin and water are added to the product of step 2), and the colostrum is obtained by high-speed shearing at 12000 rpm. The colostrum is processed by a high-pressure homogenizer at a pressure of 800 bar and circulated 5 tim...

Embodiment 2

[0040] Example 2: High transdermal absorbability nano-emulsion

[0041] 1. Composition:

[0042]

[0043] 2. Preparation method:

[0044] 1) Dissolve phospholipids in 50ml of chloroform-n-hexane solution (chloroform:n-hexane, 5:7, v / v), and dissolve salidroside in 10ml of distilled water. After stirring evenly, mix the two solutions and ultrasonicate , the obtained emulsion is freeze-dried to obtain the salidroside-phospholipid complex;

[0045] 2) Mix salidroside-phospholipid complex, caprylic acid / capric glyceride, Span 80, polyglycerol monooleate, Tween 80, and polyoxyethylene castor oil, and shear at a high speed at 12000rpm to There are no visible solids in the system;

[0046] 3) Add glycerin and water to the product of step 2), and shear at 8000rpm at high speed to obtain colostrum, which is processed by a high-pressure homogenizer at a pressure of 1200bar and circulated 7 times to obtain a transparent and clear nano-scale emulsion.

Embodiment 3

[0047] Example 3: High transdermal absorbability nano-emulsion

[0048] 1. Composition:

[0049]

[0050] 2. Preparation method:

[0051] 1) Dissolve phospholipids in 50ml of chloroform-n-hexane solution (chloroform:n-hexane, 5:7, v / v), and dissolve salidroside in 15ml of distilled water. After stirring evenly, mix the two solutions and ultrasonicate , the obtained emulsion is freeze-dried to obtain the salidroside-phospholipid complex;

[0052] 2) Mix salidroside-phospholipid complex, caprylic acid / capric glyceride, Span 80, polyglycerol monooleate, Tween 80, polyethylene glycol caprylic acid / capric glyceride, under the condition of 10000rpm High-speed shearing until there is no visible solid in the system;

[0053] 3) Add glycerin and water to the product of step 2), shear at 10,000 rpm at high speed to obtain colostrum, which is processed by a high-pressure homogenizer at a pressure of 1500 bar, and circulated 6 times to obtain a transparent and clear nano-scale emuls...

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Abstract

The invention relates to a nanoscale emulsion with high transdermal absorbency. The nanoscale emulsion contains the following components in parts by weight: 0.01 to 5 parts of salidroside, 0.5 to 20 parts of nonionic surfactant, 1 to 20 parts of phospholipid, 5 to 15 parts of oil and 60 to 90 parts of dispersion medium. Due to the existence of lipid and corneum of the skin, hydrophilic molecules are difficult to pass through the skin barrier to be absorbed by the body. The existing related preparations of salidroside are poor in stability, while according to the invention, the salidroside is wrapped in the phospholipid microcapsule nano emulsion, so that the lipid solubility of the salidroside can be effectively improved, the transdermal absorbency of the salidroside can be improved, and the application of the salidroside in the field of external use of skin can be enhanced. The lipid nanoscale emulsion containing the salidroside is high in enveloping rate, the particle size is less than 150nm, the transdermal absorbency of the salidroside can be promoted, and the nanoscale emulsion is better than that in the prior art.

Description

technical field [0001] The invention relates to a preparation of salidroside, in particular to a nano-scale emulsion with high transdermal absorption. Background technique [0002] Salidroside (Salidroside) is the main active ingredient of Rhodiola rosea. Modern pharmacological studies have proved that salidroside has health functions such as anti-fatigue effect, anti-microwave radiation effect, inhibition of blood sugar rise, and anti-peroxidation effect. Used in health products, beverages, and cosmetics. [0003] Salidroside has a molecular weight of 300 Da and excellent water solubility. Generally speaking, due to the lipids of the skin and the presence of the stratum corneum, hydrophilic molecules are difficult to be absorbed by the body through the skin barrier. Encapsulation of hydrophilic molecules in amphiphilic systems such as emulsions through technical means such as emulsions can significantly enhance the bioavailability of hydrophilic molecules. [0004] Nanoe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/06A61K8/60A61K8/92A61K9/107A61K31/7032A61K47/44A61Q19/00A61P17/18
Inventor 陈光孙晓宇杜海燕
Owner AESTHETIC TECH BEIJING
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