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Preparation method of degradable environmental sensitive polymer nano hydrogel and application

A nano-hydrogel and environmental responsive technology, which is applied in the direction of medical preparations and pharmaceutical formulas of non-active ingredients, can solve the problems of complex synthesis methods and many steps, and achieve simple preparation methods, good dispersibility, and stability Good results

Inactive Publication Date: 2013-09-18
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As far as degradable environment-responsive polymer nanohydrogels are concerned, most of the synthesis methods reported in the literature are relatively complicated, with many steps, and most of them are carried out in the organic phase.

Method used

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  • Preparation method of degradable environmental sensitive polymer nano hydrogel and application
  • Preparation method of degradable environmental sensitive polymer nano hydrogel and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1: 980 mg of N-vinylcaprolactam, 20 mg of methacrylic acid, 20 mg of sodium lauryl sulfate and 25 mg of sodium bicarbonate were dissolved in 100 mL of water. Dissolve 40 mg of N,N’-bis(acryloyl)cystamine as a cross-linking agent in 2 mL of dimethyl sulfoxide, and transfer it to the reaction system after fully dissolving. Keeping the stirring speed at 200 rpm and nitrogen atmosphere, after raising the reaction temperature to 60-80 °C, 25 mg of potassium persulfate was added quickly, and the polymerization reaction was initiated immediately. After 6 h, the reaction was stopped and slowly cooled to room temperature under nitrogen atmosphere. After the reaction, use dialysis to remove unreacted monomers, linear polymers and other impurities, and freeze-dry to obtain a phase transition temperature of 37.6 under physiological conditions (pH 7.4, 0.15 M NaCl). o C's degradable environment-responsive polymer nanohydrogels.

Embodiment 2

[0023] Example 2: 970 mg of N-vinylcaprolactam, 30 mg of methacrylic acid, 20 mg of sodium lauryl sulfate and 25 mg of sodium bicarbonate were dissolved in 100 mL of water. Dissolve 40 mg of N,N’-bis(acryloyl)cystamine as a cross-linking agent in 2 mL of dimethyl sulfoxide, and transfer it to the reaction system after fully dissolving. Keeping the stirring speed at 200 rpm and nitrogen atmosphere, after raising the reaction temperature to 60-80 °C, 25 mg of potassium persulfate was added quickly, and the polymerization reaction was initiated immediately. After 6 h, the reaction was stopped and slowly cooled to room temperature under nitrogen atmosphere. After the reaction, use dialysis to remove unreacted monomers, linear polymers and other impurities, and freeze-dry to obtain a phase transition temperature of 40.0 under physiological conditions (pH 7.4, 0.15 M NaCl). o C's degradable environment-responsive polymer nanohydrogels.

Embodiment 3

[0024] Example 3: 960 mg of N-vinylcaprolactam, 40 mg of methacrylic acid, 20 mg of sodium lauryl sulfate and 25 mg of sodium bicarbonate were dissolved in 100 mL of water. Dissolve 40 mg of N,N’-bis(acryloyl)cystamine as a cross-linking agent in 2 mL of dimethyl sulfoxide, and transfer it to the reaction system after fully dissolving. Keeping the stirring speed at 200 rpm and nitrogen atmosphere, after raising the reaction temperature to 60-80 °C, 25 mg of potassium persulfate was added quickly, and the polymerization reaction was initiated immediately. After 6 h, the reaction was stopped and slowly cooled to room temperature under nitrogen atmosphere. After the reaction, use dialysis to remove unreacted monomers, linear polymers and other impurities, and freeze-dry to obtain a phase transition temperature of 44.2 under physiological conditions (pH 7.4, 0.15 M NaCl). o C's degradable environment-responsive polymer nanohydrogels.

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Abstract

The invention belongs to the technical field of high molecular materials, and in particular relates to preparation of a degradable environmental sensitive polymer nano hydrogel and an application. According to the invention, the degradable multiple environmental sensitive polymer nano hydrogel is obtained through precipitation polymerization by taking N-vinyl caprolactam as a main monomer, N, N'-di(acrylyl) cystamine as a crosslinking agent as well as hydrophilic monomers such as methylacrylic acid, hydroxymethyl acrylamide, polyethylene glycol monomethyl ether metacrylic acid ester (Mw=2000) as comonomers. According to the invention, the raw materials are easily-available, and the preparation method is simple. According to the method, water is used as the solvent, so that the method is environment-friendly. The polymer nano hydrogel prepared is good in dispersibility, uniform in size, and good in stability and biocompatibility. The phase inversion temperature of the polymer can be adjusted by controlling the use levels of methylacrylic acid, N-hydroxymethyl acrylamide and polyethylene glycol monomethyl ether metacrylic acid ester and the pH value of the environment. Therefore, the hydrogel can be applied to release of medicines in fixed points and is used as a carrier for targeted release of medicines.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a preparation method and application of environment-responsive poly(N-vinylcaprolactam) nanogel for drug controlled release. Background technique [0002] Polymer hydrogel is a three-dimensional network structure system that can swell but not dissolve in water. Compared with hydrophobic polymers, it has many advantages, such as controllable particle size, good colloidal stability and biocompatibility. In addition, polymer hydrogels can adsorb drugs or bioactive molecules, and can keep the immobilized substances active for a long time, so hydrogels have a wide range of applications in the fields of drug controlled release. [0003] In recent years, environment-sensitive nano-hydrogels have attracted widespread attention as drug-controlled release carriers, which can sense changes in external environmental information (such as temperature, pH value, ionic stre...

Claims

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Application Information

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IPC IPC(8): C08F226/06C08F220/06C08F220/58C08F222/38C08F220/28C08F271/02C08F2/26A61K47/32
Inventor 杨武利王杨
Owner FUDAN UNIV
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