Ferroferric oxide nano-composite particle and preparation method and applications thereof

Abstract

The invention discloses a ferroferric oxide nano-composite particle and a preparation method and applications thereof. The composite particle is a ferroferric oxide nano-composite particle with the particle size of 10-30nm, and 1,4-dihydroxy anthraquinone and fluorenylmethoxycarbonyl are modified on the surface of the ferroferric oxide nano-composite particle. The preparation method comprises the steps of: firstly, carrying out a hydrothermal method on ferric trichloride hexahydrate, sodium acetate, 1,6-hexanediamine and ethanediol to obtain the ferroferric oxide nano-composite particle, then producing 1,4-dihydroxy anthraquinone, chloroacetyl chloride, and N,N-dimethylformamide into dyes, then adding the ferroferric oxide nano-composite particle, sodium carbonate and the dyes into acetonitrile to carry out a reflux reaction, carrying out solid-liquid separation, washing and drying on the obtained reaction liquor to obtain an intermediate product, then dispersing the intermediate product into the N,N-dimethylformamide, adding dispersion liquid into the fluorenylmethoxycarbonyl, stirring for 2 hours, and carrying out solid-liquid separation, washing and drying to obtain a target product. The ferroferric oxide nano-composite particle can be used for fast detecting four heavy metal ions, namely copper, zinc, cadmium and mercury in an aqueous solution.

Description

technical field [0001] The invention relates to a composite particle, its preparation method and application, in particular to a ferric oxide nanocomposite particle, its preparation method and application. Background technique [0002] Based on the superparamagnetism of ferroferric oxide nanoparticles which are different from conventional magnetic materials, it is easy to separate and recycle them by using an external magnetic field. , protein separation, drug loading and release, early diagnosis and treatment of cancer and magnetic storage and other fields have great application value. Recently, people have made some attempts and efforts in order to explore and expand the application range of ferric oxide nanoparticles, such as a "multifunctional core" disclosed in the Chinese invention patent application document CN 102120168A published on July 13, 2011. Fluorescence-encoded magnetic microspheres with shell structure and its preparation method". The magnetic microspheres...

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Problems solved by technology

However, there are deficiencies in both the magnetic microspheres and their preparation methods. First, although the final product has good fluorescent and magnetic properties, as well as biological stability and water solubility, and can be further functionally modified , to be applicable to the field of biomedicine, but it cannot be used to detect a variety of heavy metal ions that widely exist in related fields such as drinking water, environment, food and medicine; and excessive copper content in the human body will cause gastrointestinal disorders, and It can cause damage to liver, kidney and other organs. If the zinc content exceeds the standard, symptoms such as nausea, vomiting, acute abdominal pain, diarrhea and fever will occur, which is the so-called zinc poisoning. Cadmium is a carcinogen that can cause prostate cancer. Cadmium poisoning It will cause calcium loss, osteomalacia, etc. Excessive mercury content will cause respiratory failure, liver and kidney damage and other serious consequences

Second, the particle size of the final product is too large to be conveniently used in microenvironments, such as the intracellular environment

Finally, the preparation method not only cannot produce the target products for detecting four heavy metal ions of copper, zinc, cadmium and mercury, but also needs to coat the surface of ferric oxide nanoparticles with silicon dioxide to make the surface aminated. In addition to making the process complicated, it also increases the cost of production

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