Method for synthesizing o-amino diaryl ether and o-amino diaryl sulfur ether
A technology of o-amino diaryl sulfide and o-amino diaryl ether, which is applied in chemical instruments and methods, formation/introduction of amino groups, preparation of amino hydroxy compounds, etc. problem, to achieve the effect of direct reaction, simple method and good activity
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Embodiment 1
[0039] Compound 1: Add metal copper powder (0.05mmol), cesium carbonate (1.0mmol) and polyethylene glycol-600 (2.0g) into a 25mL reaction flask, fill with nitrogen protection, add benzothiazole (0.5mmol) and iodobenzene (1.0 mmol). The reaction mixture was at 140 o Reaction at C until the reaction of the raw materials is complete. After cooling to room temperature, the solvent was evaporated under reduced pressure and separated by column chromatography (petroleum ether: diethyl ether: triethylamine = 30: 1: 1) to obtain a pale yellow liquid. Yield 96%.
Embodiment 2
[0041] Compound 2: Add metal copper powder (0.05mmol), cesium carbonate (1.0mmol) and polyethylene glycol-600 (2.0g) into a 25mL reaction flask, fill with nitrogen protection, add benzothiazole (0.5mmol) and o-iodine Toluene (1.0 mmol). The reaction mixture was at 140 o Reaction at C until the reaction of the raw materials is complete. After cooling to room temperature, the solvent was evaporated under reduced pressure and separated by column chromatography (petroleum ether: diethyl ether: triethylamine = 30: 1: 1) to obtain a pale yellow liquid. Yield 94%.
Embodiment 3
[0043] Compound 3: Add metal copper powder (0.05mmol), sodium carbonate (1.0mmol) and polyethylene glycol-400 (2.0g) to a 25mL reaction flask, fill with nitrogen protection, add benzothiazole (0.5mmol) and p-iodine Aniline (1.0 mmol). The reaction mixture was at 140 o Reaction at C until the reaction of the raw materials is complete. After cooling to room temperature, the solvent was evaporated under reduced pressure and separated by column chromatography (petroleum ether: diethyl ether: triethylamine = 30: 1: 1) to obtain a pale yellow liquid. Yield 93%.
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