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Titanium-hydroxylapatite gradient coating and preparation method and application thereof

A technology of hydroxyapatite and gradient coating, which is applied in coatings, medical science, and prostheses, and can solve problems such as insufficient bonding between coatings and implants, hydroxyapatite stability, and biological activity damage. Achieve good biological activity, improve long-term stability, and reduce driving force

Inactive Publication Date: 2009-12-30
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a Ti- Hydroxyapatite gradient coating, the coating forms a gradient by continuously changing the volume ratio of titanium powder and hydroxyapatite in the coating, thereby maintaining the biological activity of the coating and reducing the The difference in thermal expansion coefficient and elastic modulus between implants improves the bonding strength of the coating to the implant matrix

Method used

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  • Titanium-hydroxylapatite gradient coating and preparation method and application thereof
  • Titanium-hydroxylapatite gradient coating and preparation method and application thereof
  • Titanium-hydroxylapatite gradient coating and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Example 1 Implant surface morphology observation

[0016] 100 solid cylindrical threaded implant bases were machined with titanium-6 aluminum-4 vanadium (Ti-6AL-4V) rods, and the materials and processing were provided by Guangzhou Nanfeng Biotechnology Co., Ltd. The specifications are: a total length of 7.5mm, a cylindrical shape with a length of 6.0mm at the lower end, a diameter of 3.0mm, a thread pitch of 1.0mm, and a thread depth of 0.3mm; figure 1 ). Degreasing and cleaning the implant matrix: Ultrasonic cleaning in acetone, 75% ethanol, and deionized water for 10 minutes each, and drying at 50° C. for 24 hours. Three sets of implants were constructed with different surface treatments:

[0017] ① Control group I: Mechanically cut implants (Machine Aided, MA), 25 implant bases were put into 50% nitric acid solution for passivation for 50 min.

[0018] ②Control group II: Hydroxyapatite-coated implants (Hydroxyapatite, HA), hydroxyapatite powder, using low-pressure...

Embodiment 2

[0022] Example 2 Analysis of Implant Surface Chemical Structure

[0023] One implant was randomly sampled from each group of implants treated above, and the surface morphology of the samples was observed with a scanning electron microscope (Scanning Electron Microscopic, SEM, JSM-5910). After SEM observation, X-ray diffraction (XRD, D / max-rc) was used to analyze the chemical structure of the implant surface on the surface of each sample. Through the XRD pattern of HA powder, HA coating and Ti-HA gradient coating, it can be seen that the coating The crystallinity of apatite is lower than that of HA powder. In addition to the broadened apatite peak shape and enhanced CaO phase in the XRD patterns of the two coatings, there is also a TCP (tricalcium phosphate) phase, which may be caused by the spraying process. The high temperature in the medium increases the decomposition of apatite. Overall, the gradient coating design did not significantly change the apatite crystal phase.

Embodiment 3

[0024] The mensuration of embodiment 3 coating intensity

[0025]The bonding strength between the coating and the substrate is characterized by tensile strength. The test method of tensile strength is carried out with reference to the ASTM-C633279 standard, and the bonding strength of the two coatings is tested respectively by using a JDL-50KN tensile testing machine. Use two cylindrical titanium alloy rods with a diameter of 25mm, one end of which is Ti-HA gradient coating or HA coating, bonded together with another blank titanium alloy rod through E7 resin glue, and place in an oven at 100°C / 3h , and then use a tensile testing machine to stretch to both sides until the coating falls off. Four pairs of samples were tested for each coating, and the average value of the test results was used to represent the bonding strength of the coating.

[0026] It was found that the design of the gradient coating improved the bonding strength between the coating and the substrate to a ce...

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Abstract

The invention discloses a titanium-hydroxylapatite gradient coating and preparation method and application thereof. The coating of the invention takes matrix as basement and comprises the following layers from inside to outside: a titanium powder layer, a titanium powder and hydroxylapatite mixed layer, wherein the volume ratio of the two is 6:4, a titanium power and hydroxylapatite mixed layer, wherein the volume ratio of the two is 4:6, and a hydroxylapatite layer. The coating of the invention is sprayed by low pressure plasma spraying technology and can be used for treating titanium alloy implant surface. The coating of the invention has high stability and favourable retention of bioactivity and can reduce coefficient of thermal expansion and elastic modulus difference between coating material and implant, so that residual stress of coating is reduced and bonding strength with the implant is improved; and the coating of the invention is sprayed by applying plasma technology, thus poriness of the coating can be reduced and bonding strength with the implant can be improved.

Description

technical field [0001] The invention relates to the field of coating preparation of bioactive implants, in particular to a titanium-hydroxyapatite gradient coating and a preparation method and application thereof. Background technique [0002] Hydroxyapatite (HA), the chemical formula is Ca 10 (PO 4 ) 6 (OH) 2 , has a chemical composition and crystal structure similar to the main mineral apatite in human bones and teeth, and is the main inorganic component of human bone tissue. HA is a bioactive ceramic material with excellent biocompatibility and bioactivity. It can react with the bone tissue of the body to form a chemical bond and promote the growth of bone tissue on its surface. The HA bioactive coating deposited on the surface of the titanium alloy substrate fully integrates the respective advantages of metal materials and bioactive ceramic materials. It not only has the high strength and toughness of metal materials, but also has good biological properties and bioco...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06A61L27/12
Inventor 蒋立坚王丽娟林诗耿
Owner SUN YAT SEN UNIV
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