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Pharmaceutical compositions for prevention or treatment of diseases caused by interleukin-6 production, comprising an antibody to interleukin-6 receptor (IL-6R antibody). As the IL-6R antibody, an antibody of animals other than the human such as mice, rats, etc., a chimeric antibody between these and a human antibody, a reshaped human antibody, etc. may be used. The pharmaceutical compositions are useful for prevention or treatment of diseases caused by interleukin-6 production such as plasmacytosis, anti-IgGl-emia, anemia, nephritis, etc.

A method and apparatus directed to the repair of regurgitant mitral valves. Mitral valve regurgitation occurs due to miscoaptation of mitral valve leaflets. The mitral valve repair apparatus of the present invention is comprised of a tongue plate which is supported by a suture ring. The apparatus is inserted into the mitral valve orifice with the suture ring sutured to the mitral valve annulus placing the tongue plate between the two mitral valve leaflets. When the mitral valve opens, blood flows through the orifices of the apparatus. When the mitral valve closes, the two miscoaptated mitral valve leaflets cover the orifices on the apparatus and the tongue plate blocks the hole formed by leaflets and seals the leaky flow.

Compositions and methods for promoting tissue regeneration, particularly skin regeneration, with adipose-derived stem cells are provided. Additionally methods and compositions for promoting tissue regeneration with adipose-derived stem cell side population cells are provided. The adipose-derived cells are administered in a tissue regenerating effect amount optionally with a bioactive agent. Additionally the adipose derived cells can be autologous or syngeneic.

The present invention relates to an actuator for generating a rotational positioning movement, wherein the actuator comprises an electric motor (1) and a reduction gear (2) which consists of two assemblies (4, 5). The first assembly (4) is formed by a gear of the harmonic, cycloid or wobble, type and the second assembly (5) by a gear of the single-step or multistep planetary or Wolfrom type, whereby both assemblies (4, 5) are so tuned to each other, that the reduction gear (2) is not self-locking.

Components of an ultrasonic sensor are contained in a cylindrical casing having an end wall closing one end of the casing. A vibrator such as a piezoelectric element is disposed in the casing in contact with the end wall. An integrated circuit chip that includes a signal generator, a filter device and a temperature sensor is contained in the casing. Vibrations generated in the vibrator are transferred to the end wall that transmits ultrasonic waves. Ultrasonic waves received by the end wall are converted into electrical signals in the vibrator. Frequency of the transmitting signals and a frequency region of the signals to be received are controlled according to the ambient temperature, so that they always coincide with a resonant frequency of the end wall which changes according to the ambient temperature. Thus, high transmitting/receiving efficiency is always realized, irrespective of the ambient temperature.

An optoelectronic device includes at least first and second light-emitting nanowires on a support, each comprising an area for the injection of holes and an area for the injection of electrons, a series electric connection including a connection nanowire on the support, which includes a first region forming an electric path with the hole injection area of the first nanowire, a second region forming an electric path with the electron injection area of the second nanowire, and a third region enabling a current to flow between first and second regions. Also included are a first conductive area connecting the hole injection area of the first nanowire and the first region of the connection nanowire and electrically insulated from the second nanowire, and a second conductive area connecting the second region of the connection nanowire and electron injection area of the second nanowire and electrically insulated from the first nanowire.

A safety apparatus for a rider motivated wheeled vehicle, the safety apparatus including a remote control module and a remotely actuable braking apparatus. The remote control module includes an electronic control signal activation module, a manual signal activator coupled for activating the electronic control signal activation module for generating a control signal, and a power supply coupled for powering the electronic control signal activation module. The remotely actuable braking apparatus includes an auxiliary brake device that is positionable for engaging at least one wheel of a rider motivated wheeled vehicle; an electronic actuator module coupled to the auxiliary brake device and being responsive to a received control signal for operating the auxiliary brake device, and a power supply coupled for powering the actuator module.

A system and method for creating a customized portal environment website that retrieves content from external websites and presents this content with a consistent and controlled look and feel. Three features of this invention that enable the consistent look and feel are clipping, scrubbing and link behavior tools. The clipping tool identifies the structure of clipped pages. The structure of the clipped content is stored in a database in the system. As the system dynamically retrieves clipped pages from the target site, the system compares the structure of the retrieved clip to the anticipated, stored structure of the clip. If the two structures match, the clipped page is rendered in the look and feel of the custom website. If the structures do not match, the dynamically clipped page is displayed in a new separate window. The scrubbing feature of the present invention allows the designer of the website to define a global structure for all pages that are retrieved from a particular domain. If a requested page does not conform to the defined structure, the system opens a new window for the page. The link behavior tool of the present invention traps a request for the embedded link upon it's execution and redirecting the request to a page that has already been approved and clipped or by opening a new window for the embedded link.

A tamper resistant drug delivery system made of at least one lipid, at least one gelling agent and at least one sympathomimetic amine, such as for example pseudoephedrine, wherein the system gels in the presence of water or a solution containing water and ethanol, wherein the sympathomimetic amine releases into the digestive system when ingested, and wherein the weight ratio of gelling agent to lipid is less than 1:1.4.

Substituted 1-propiolylpiperazine compounds corresponding to formula I

in which X denotes N or C—R², and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine compounds, pharmaceutical compositions containing such substituted 1-propiolylpiperazine compounds, and the use of such substituted 1-propiolylpiperazine compounds for modulating mGluR5 receptor activity or for treating or inhibiting pain and various other conditions, especially conditions at least partly mediated by the mGluR5 receptor.

The present invention involve a method for severance of materials made of polycarbonate, polycarbonate laminate and aciylic/polycarbonate laminate, a canopy fracturing system and a conopy having the canopy fracturing system.

The present invention utilizes a linear shaped explosive charge placed at a predetermined distance or stand off from the polycarbonate material to be severed. The coreload of the charge is determined such that the minimum coreload necessary to effect severance of a given thickness of polycarbonate material is utilized. A retainer is placed around the charge and affixed to the material such that the charge is at the proper stand off from the material. The retainer surrounds the back side of the charges but leaves open space between the charge and the material to be severed. Upon detonation, the charge creates an explosive cutting force, or jet blast, that severs the polycarbonate material. Also, provided are methods for intersecting explosive charges about a pattern to be severed and methods for transferring detonation between such intersecting explosive charges.

The present invention relates generally to chemical and biological decontamination solutions and methods of using them. The invention is useful for decontaminating and/or disinfecting a wide range of compounds and organisms. In particular, the systems, methods, solutions, and formulations of the invention can be used to remove and/or neutralize organophosphates, mustard agents, and other toxic chemicals, bacteria, bacterial spores, fungi, molds and viruses.

A computer-implemented method, which enables the data to be clustered without being required to perform any distance calculations among the points of the dataset, includes assigning points of a dataset to cells of a cellular automaton; assigning each cell, having a data point assigned, a distinct state value and a constant temperature value; and assigning all cells, to which a data point is not assigned, a unique state value different from the state values utilized for cells having a data point and to a temperature lower than the constant temperature value; selecting a cell in the cellular automaton randomly; calculating the average temperature of the selected cell and its neighbor cells; setting the temperature of the cells having no data point, as the average temperature; if a neighbor cell temperature is above the predetermined threshold value, moving this neighbor cell to the state of the selected cell.

A lifter is provided with operating levers, which, against driving forces of actuators that switch the ratchet pawls to unengaged orientations, switch the ratchet pawls to engaged orientations of being engaged with ratchet gears, is provided with a link mechanism, which, when a workpiece support base is being lowered by collapsing motions of a pair of right and left crosslink mechanisms supporting the workpiece support base and a difference arises in movement amounts of movable support shafts at lower end sides of the respective crosslink mechanisms, converts the movement amount difference to an operating force of the operating lever at the larger movement amount side, and is such that by the operating lever at one side being driven by the link mechanism, the operating lever switches the ratchet pawl at the larger movement amount side to the engaged orientation.

The biocidal products do not pose any particular risks to the environment or health. Indeed, the active substances and additives that constitute the biocidal products according to the invention are of plant, agricultural, and renewable origin, and are furthermore completely biodegradable. The concentrated biodegradable biocidal formulation includes compounds from renewable plant resources, such as at least lactic acid and/or citric acid in a proportion of 76 wt % to 98 wt % relative to the total weight of the formulation; and at least one sodium and/or potassium carboxylate including 5 to 16 carbon atoms serving as an anionic surfactant in a proportion of 2 wt % to 24 wt % relative to the total weight of the formulation.