62results about How to "Function is lost" patented technology

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

This invention provides novel compounds comprising the following anti-inflammatory pharmacore:wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.

A device used to treat heart disease by decreasing the size of a diseased heart, or to prevent further enlargement of a diseased heart. The device works by limiting the volume of blood entering the heart during each cardiac cycle. The device partitions blood within the heart, and protects the heart from excessive volume and pressure of blood. The device is placed within the interior of the heart, particularly within a ventricular cavity. The device is a hollow sac, with two openings, which simulates the shape and size of the interior lining of a ventricle of a normal heart. It allows the ventricle to fill through one opening juxtaposed to the annulus of the inflow valve to a predetermined, normal volume, and limits filling of the heart beyond that volume. It then allows blood to be easily ejected through the second opening through the outflow valve. By limiting the amount of blood entering the ventricle, the ventricle is not subjected to the harmful effect of excessive volume and pressure of blood during diastole, the period of the cardiac cycle when the heart is at rest. This allows the heart to decrease in size, or to reverse remodel, and to recover lost function. In some applications, a second device may be simultaneously placed inside the heart to take up excessive space between the heart and the primary device.

This invention provides novel compounds comprising the following anti-inflammatory pharmacore:wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.

An adjustable lift support apparatus includes a base, a sleeve attached onto the base, at least one meshing device, a shaft, and a support attached at the shaft. At least one groove is formed on an inner surface of the sleeve along a first axial direction. Each meshing device corresponds to one of the at least one groove and includes a flexible protrusion. The shaft is inserted into the sleeve. At least one rack is provided on an outer surface of the shaft along a second axial direction, such that the flexible protrusion of the meshing device is meshed between two neighboring teeth of the at least one rack. The support is lifted or lowered by an external force to make each of the at least one rack move with respect to the flexible protrusion of the corresponding meshing device, so as to adjust the height of the support.

A system made up of methods and techniques designed to improve the body's postural alignment, joint range, muscle hydration, bone density, and overall musculoskeletal health. The system combines a series of exercises designed to lengthen and strengthen muscles, fascial and myofascial tissue. The system is used in combination with a vibrating roller device, which can also be used with a head cradle. The application of the vibrational motion to the body in combination with the techniques described herein work to stimulate fascial tissue and confer benefits on the user which will improve the overall quality of life.

An adjustable lift support apparatus includes a base, a sleeve attached onto the base, at least one meshing device, a shaft, and a support attached at the shaft. At least one groove is formed on an inner surface of the sleeve along a first axial direction. Each meshing device corresponds to one of the at least one groove and includes a flexible protrusion. The shaft is inserted into the sleeve. At least one rack is provided on an outer surface of the shaft along a second axial direction, such that the flexible protrusion of the meshing device is meshed between two neighboring teeth of the at least one rack. The support is lifted or lowered by an external force to make each of the at least one rack move with respect to the flexible protrusion of the corresponding meshing device, so as to adjust the height of the support.