The invention discloses a natural botanical pesticide prepared from euphorbia pekinensis, gelsemium elegans, lightyellow sophora root, common threewingnut root, tobacco, sessile stemona root, fistular onion juice, arisaema bockii engler, monkshood, cortex meliae and semen momordicae. According to the natural botanical pesticide, the monarch, minister, assistant and guide theory in traditional Chinese medicine is adopted, natural Chinese herbal medicines are adopted for reasonable compatibility, and all the components have a synergistic effect, so that the natural botanical pesticide has the effects of powerfully destroying digestive systems and metabolic functions of pests, destroying vagus nerves of the pests and inhibiting respiratory systems, and can kill all soft mouth-eating pests and piercing-sucking pests; and the natural botanical pesticide is high in pesticide efficacy, stable in pesticide effect, long in pesticide effect time (not less than 14 days), easy to degrade, free of environmental pollution, free of peculiar smell, free of residues, free of pollution, green, safe and environmentally friendly.