The invention relates to the technical field of clothes packaging, and specifically discloses a full-automatic clothes folding machine. The full-automatic clothes folding machine comprises a machine frame, wherein a first conveying mechanism, a second conveying mechanism, a cloth pressing mechanism, a cloth folding mechanism, a positioning mechanism, a cloth turning mechanism and an output sectionare arranged on the machine frame, the cloth pressing mechanism is positioned above the second conveying mechanism, the position of the cloth folding mechanism on the machine frame corresponds to theposition of the cloth pressing mechanism, the positioning mechanism is located on the machine frame at the position where the clothes are away from the cloth folding mechanism, the cloth turning mechanism is at the position where the machine frame corresponds to the positioning mechanism, and the output section is located at the position where the machine frame is located at the output end of thesecond conveying mechanism. The full-automatic clothes folding machine has the characteristics of no deviation of a conveying strip, good conveying effect, convenient adjustment of the folding width,better adjustment precision, better folding flatness, better folding consistency, better appearance, higher degree of automation, higher production efficiency, low labor intensity and ability of adapting to large-yield demand.