41results about How to "Determining effect" patented technology

A medical characterization system is configured to input medical-related continuous parameters and discrete data so as to calculate a characterization timeline indicative of a physiological condition of a living being. A data source is in sensor communications with a patient so as to generate a continuous parameter. The data source also provides test data responsive to the patient at a test time. The test data is available to a characterization processor at a result time. The characterization processor is also responsive to the continuous parameter so as to generate a medical characterization as a function of time. A characterization analyzer enables the characterization processor to update the medical characterization in view of the test data as of the test time.

A medical characterization system is configured to input medical-related continuous parameters and discrete data so as to calculate a characterization timeline indicative of a physiological condition of a living being. A data source is in sensor communications with a patient so as to generate a continuous parameter. The data source also provides test data responsive to the patient at a test time. The test data is available to a characterization processor at a result time. The characterization processor is also responsive to the continuous parameter so as to generate a medical characterization as a function of time. A characterization analyzer enables the characterization processor to update the medical characterization in view of the test data as of the test time.

The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.

Methods of evaluating treatments for vascular disease are described. The treatments can include administration of pharmaceutical, chemical, or biological agents. Vascular tissue is removed from a first site in a vascular lumen and optionally analyzed. A treatment is administered to the patient, followed by removal of a second portion of vascular tissue from a second site. The vascular tissue from both the first and second site are compared to learn the effect of the treatment. Treatments can include placement of prosthetic devices such as stents in the lumen. Whether or not the vascular tissue recurs at a site after removal can be monitored as a measure of the success of a given treatment.

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

A gesture sensing apparatus configured to be disposed on an electronic apparatus is provided. The gesture sensing apparatus includes at least one optical unit set disposed beside a surface of the electronic apparatus and defining a virtual plane. Each of the optical unit set includes a plurality of optical units, and each of the optical units includes a light source and an image capturing device. The light source emits a detecting light towards the virtual plane. The virtual plane extends from the surface toward a direction away from the surface. The image capturing device captures an image along the virtual plane. When an object intersects the virtual plane, the object reflects the detecting light in the virtual plane into a reflected light. The image capturing device detects the reflected light to obtain information of the object. An electronic system having a gesture input function is also provided.

Systems and methods are described that simulate a credit score. The system enables a user to modify a credit data element in order to determine its effect on a credit score. The user can modify the element directly or simulate an action that, if performed, would modify the element. Since the number of possible modifications and actions can be overwhelming, in one embodiment, the system suggests modifications and actions to be simulated. These suggestions can be tailored to a user's goal, such as increasing a credit score by a particular number of points or allocating a particular sum of money in order to maximize a credit score. In one embodiment, the system obtains credit data from multiple credit bureaus and can determine credit scores using different algorithms, such as the different algorithms used by the different credit bureaus.

The present invention relates to the production of adenosine deaminase (ADA) deficient mice and the use of such mice as an animal model for dysfunctions associated with elevated adenosine levels. Also, provided by the present invention are methods of treating dysfunctions associated with elevated adenosine levels and methods of screening compounds for pharmaceutical activity in the treatment of dysfunctions associated with elevated adenosine levels.

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

A biocidal article, includes a surface including a plurality of polymers covalently attached to the surface. The polymers include biocidal cationic groups. The polymers have a molecular weight distribution or polydispersity less than 3. A grafting density of the polymers on the surface is controlled, average degree of polymerization of the polymers is controlled and repeat units of the polymers are chosen to provide a predetermined charge density arising from the cationic groups. A method of analyzing biocidal activity of biocidal surface agents includes the steps: attaching a plurality of chemical entities to one or more surfaces so that at least one physiochemical property is varied, each of the chemical entities comprising at least one biocidally active component; and exposing the chemical entities to at least one biological agent to determine the effect of the at least one physiochemical property upon biocidal activity. The biocidal activity can, for example, be antibacterial activity or sporicidal activity. The at least one physiochemical property can, for example, be varied in a preferably systematic manner.

Computer implemented methods for processing transactions involving chemical products include receiving at a server computer from a client computer transaction data that includes a product identifier. In response, testing of a sample of the identified product is scheduled and results of the sample testing are stored in a database. The results may be retrieved in response to a subsequent query from the user and sent over a network to the user. In another aspect, characteristics of a chemical product produced according to a particular formulation are determined, the formulation may be modified, and characteristics of a produce produced according to the modified formulation can be determined. A networked computer system that includes a server, a database, and a memory is configured to exchange data with client computers and is coupled to a database that stores chemical product data for a number of chemicals materials. The chemical product data can include, e.g., starting point formulations (i.e., recipes combining chemical materials to produce a product). The memory includes instructions that can configure the server to communicate over a computer network with a client computer. The client computer can communicate a product identifier to the server and, based on that identifier, the server may query the database to retrieve chemical product data which is then returned to the client computer.

The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, gentotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.

The process of the present invention involves forming a series of radiation-curable compositions having uniformly consistent properties.The process involves forming a pre-composition, measuring an in-situ sample of said pre-composition to determine a property of the cured pre-composition and adding at least one adjusting agent to form a radiation-curable composition and repeating this process to form at least one further radiation-curable composition wherein said property value for each of said radiation-curable composition and said at least one further radiation-curable composition are each within a target value range for said property.

Embodiments of the present invention relate to apparatuses, systems, methods and computer program products for determining impact retirement scores and identifying solutions to aid a user in retirement planning. In one embodiment, a system comprises at least one processing device configured to receive retirement information of a primary user, calculate a retirement score based on a primary user profile, determine relationships of the primary user and hence determine a plurality of secondary users. Further, the at least one processing device is configured to generate user profiles for the secondary users and analyze the user profiles to determine if the secondary users affect the primary user's retirement score. The system then determines the impact retirement score for the primary user, wherein the impact retirement score is an estimate of the primary user's preparedness for the impact of the secondary users on the primary user's retirement.

A method of determining the effect of an agent on a diploid cell and / or on an expression or activity of a polypeptide expressed within the diploid cell is provided. The method is effected by: (a) administering an exogenous RNA molecule encoding the polypeptide into the diploid cell; (b) contacting the diploid cell with the agent; and (c) monitoring a phenotype of the diploid cell and / or the expression or activity of the polypeptide within the diploid cell, thereby determining the effect of the agent on the diploid cell and / or on the expression or activity of the polypeptide expressed within the diploid cell.

Embodiments of the invention are directed to systems, methods, and computer program products for assessing retirement planning based on a retirement score. The system is configured to access the assets and the liabilities of a user, a user profile, fund in-flows and fund out-flows for the assets and the liabilities over a past time period by analyzing transactions for the assets and the liabilities, estimated rates of return for the assets that provide returns, and financial behavior of the user. In response, calculate a retirement score for the user indicating the user's preparedness for retirement at a future predetermined date, wherein the future predetermined date is selected by the user. In response, display the retirement score on a retirement planning interface on a user device.

Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

Embodiments of the invention are directed to systems, methods, and computer program products for assessing retirement planning based on a retirement score. The system is configured to access the assets and the liabilities of a user over a network of servers, wherein the assets include illiquid assets and liquid assets, wherein the assets and the liabilities comprise a balance sheet; determine asset values and liability values; determine a retirement score based on the asset values and the liability values; and determine a market event; and determine an increase or decrease in the retirement score based on the market event.

Embodiments of the invention are directed to systems, methods, and computer program products for assessing impact of life events on retirement planning. The system is configured to calculate a retirement score for the user indicating the user's preparedness for retirement at a future predetermined date, wherein the future predetermined date is selected by the user. In response, receive a user selection of a life event that could occur for the user; calculate a life event score for the selected life event based on receiving life event information associated with the at least one life event selected by the user; and initiate a presentation of a payment user interface to the user, to provide the calculated life event score to the user.

Embodiments of the invention are directed to systems, methods, and computer program products for assessing retirement planning based on a retirement score. The system is configured to access the assets and the liabilities of a user over a network of servers, wherein the assets include illiquid assets and liquid assets, wherein the assets and the liabilities comprise a balance sheet; determine asset values and liability values; determine a retirement score based on the asset values and the liability values; and in response to determining the retirement score is equal to or greater than a threshold score, provide a first recommendation to the user, the first recommendation comprising an investment plan for at least a portion of the liquid assets.

The present invention relates to the technical field of immunology and the treatment of diseases mediated and / or indicated by the presence of a ligand of NK receptor NKG2D, such as major histocompatibility complex class I chain related (MIC) A and B molecules on the cell surface of diseased tissue or cells. In particular, the present invention makes use of the surprising finding that the stress-inducible endogenous danger signals HSP70 and MICA / B synergistically activate NK cells against tumors. Methods and compositions for the prevention and treatment of infectious diseases, primary and in particular metastatic neoplastic diseases, including, but not limited to human sarcomas, carcinomas and melanomas are provided.

The present invention is a test kit for rapidly diagnosing influenza according to the principles of immunochromatography, and the purpose thereof is to provide a test kit for the influenza A virus in which the sensitivity in detecting the influenza A virus is greater than in conventional test kits, and a determination of “positive” is obtained stably and with high precision at an earlier time during the onset of influenza symptoms. The present invention pertains to a kit for detecting influenza A virus, in which an antibody that is in solid phase in the chromatographic medium enters into an antigen-antibody reaction with native nuclear proteins of the influenza A virus, but in Western blots the antibody does not enter into antigen-antibody reactions with full-length nuclear proteins of the influenza A virus that have been separated using SDS-polyacrylamide gel electrophoresis.

Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. An optical diagnostic method for an eye includes obtaining a sequence of aberration measurements of the eye, identifying an outlier aberration measurement of the sequence of aberration measurements, and excluding the outlier aberration measurement from the sequence of aberration measurements to produce a qualified sequence of aberration measurements. The sequence of aberrations measurements can be obtained by using a wavefront sensor. An optical correction for the eye can be formulated in response to the qualified sequence of aberration measurements.

A system for generating cost estimates and budgets for construction / maintenance projects for a property(s) allowing a user to select cost database from which to select cost data for the performance of an action item. The different databases may correspond to different geographic locations and include labor, materials and equipment costs for the selected location. The system further provides for presenting a hierarchical listing of cost line items with a cost associated with the item and searchable by description or an item identification number. The system still further allows for a user to click on an individual action item and obtain line item cost information relating to the selected action item.

Embodiments of the invention are directed to systems, methods, and computer program products for assessing impact of financial events calendared in the future on retirement planning. The system is configured to receive information associated with financial institution accounts of the user; initiate presentation of a spend user interface to the user, wherein the spend user interface comprises at least selectable financial event options for the one or more financial events that could occur for the user; receive a user selection of a financial event and a future predetermined date associated with the financial event selected by the user; determine one or more payment options from the financial institution accounts for the financial event selected by the user; and calculate a new amount of spendable funds or a new estimated amount of time associated with an availability of the amount of funds available in the financial institution accounts.

The present invention provides a method for testing the efficiency of delivering an inhibitory polynucleotide to a target cell or tissue. The invention also provides a method for testing efficiency of delivering and efficacy for an effect on tumor size of an inhibitory polynucleotide against a target gene.

A method for analyzing input output (I / O) pin arrangements to determine the effect of differential pair and power and ground pin placement on signal quality which includes constructing an array of pins, arranging a plurality of differential pairs within the array of pins to provide a pin arrangement, exciting each of the differential pairs within the pin arrangement, monitoring coupled noise on other differential pairs within the pin arrangement, and analyzing the pin arrangement based upon the monitoring.

A system for determining an effect of a non-uniform electric field on a dielectric particle includes a pair of electrodes for generating the non-uniform electric field, a function generator in communication with a computer and the electrodes for changing the frequency of the electric field, and a camera in communication with a microscope and the computer for capturing a series of images of the dielectric particle in the non-uniform electric field. The computer is programmed to detect changes between the images in the series of images to determine the effect of the non-uniform electric field on the dielectric particle.

The invention relates to the production of hepatocyte cell lines useful in toxicology screens or therapy. A mammalian hepatocyte comprises, as a single polypeptide, a fusion protein comprising a c-myc protein and an oestrogen receptor, or functional fragments thereof.