The present invention discloses a system and method for achieving intercommunication between an IPv4 network and an IPv6 network based on an NAT64, and relates to the field of an IPv6 transitory technology. The method includes the following steps: ensuring that an NAT64 module is connected to the IPv4 network and the IPv6 network to achieve global enabling and interface enabling of functions of the NAT64; receiving, by the NAT64 module, a data message sent from a network side, updating a dynamic table, establishing address mapping information which maintains a sub-module, and obtaining an address 5-tuple flow after translation according to the protocol version of the data message; performing, by the NAT64 module, protocol translation on an IPv4 message head and an IPv6 message head; and forwarding, by an IPv4 / IPv6 message forwarding sub-module, a new data message completing the translation of address and the translation of a protocol to a target address. Relevant functions of the NAT64 can be fully achieved on a conventional digital communication product, the performance consumption of equipment and the usage of system resources are effectively reduced, and the working efficiency is increased.