The present invention relates to novel molecules useful in the prevention, amelioration, treatment and / or diagnosis of diseases, disorders and abnormalities associated with alpha-synuclein (a-synuclein, A-synuclein, a-synuclein, A-syn, alpha-syn, aSyn, a-syn) aggregates, including, but not limited to, Lewy bodies and / or Lewy neurons, such as, but not limited to, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein, Alpha-synuclein and Alpha-synuclein. For example, Parkinson's disease, multi-system atrophy, dementia with Lewy bodies (LBD; dementia with Lewy bodies (DLB) ('pure 'dementia with Lewy bodies), dementia with Parkinson's disease (PDD) or diffuse Lewy body disease. The present invention relates to alpha-synuclein binding molecules, in particular alpha-synuclein antibodies or antigen binding fragments or derivatives thereof, and uses thereof. The molecules of the invention may also be used to determine the predisposition of predisposition to such a condition, disease, or abnormality, to monitor a residual condition, disease, or abnormality, or to predict the responsiveness of a patient suffering from such a condition, disease, or abnormality to a treatment with a certain drug.