The invention provides an application of
lactobacillus crispatus in preparation of
female contraceptives. According to the technical scheme, firstly, the influence of
lactobacillus crispatus on spermsis studied, and experiments are conducted in an in-vitro co-incubation mode and an animal vaginal administration mode respectively; experimental results show that the
lactobacillus crispatus has obvious adhesion to sperms, so that the
sperm motility and swimming ability are remarkably reduced. Based on the found new properties of the
lactobacillus crispatus, the new application of the
lactobacillus crispatus in preparation of
female contraceptives is determined. Animal experiments show that when a
vaginal suppository containing the
lactobacillus crispatus liquid acts on the
vagina of a femalemouse, the
pregnancy rate of the female mouse can be accurately reduced, and the contraceptive rate can reach about 50%. A lactobacillus crispatus bacterial suspension is safe and non-toxic, the
probiotic effect of the lactobacillus crispatus bacterial suspension is combined with reproductive contraception, the limitation of a traditional contraception mode is broken through, and the lactobacillus crispatus bacterial suspension is safe, effective and reversible, can help to adjust
genital tract micro-ecological balance of women and is of great significance to
reproductive health of women.