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58 results about "Fc receptor binding" patented technology

Antigen binding molecules with increased Fc receptor binding affinity and effector function

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Immunoglobulin constant region fc receptor binding agents

IVIG replacement compounds are derived from recombinant and / or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage / administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases.
Owner:GLIKNIK +1

Antigen binding molecules with increased Fc receptor binding affinity and effector function

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human CD20. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Methods for converting or inducing protective immunity

The invention is based in part on the finding that suppressing regulatory T cell function is needed in order to convert passive immunity into active antigen-specific immunity. Generally, the methods of the invention comprise at least the combination of: (1) increasing the amount of immune complexes in the subject, wherein the immune complex comprises a target antigen and a immunoglobulin molecule comprising (i) a variable region specific to the target antigen and (ii) a Fc receptor binding region; and (2) inhibiting regulatory T cell function or decreasing / depleting the regulatory T cell population in the subject.
Owner:THE TRUSTEES OF COLUMBIA UNIV IN THE CITY OF NEW YORK

Anti-cd20 glycoantibodies and uses thereof

The present disclosure relates to a novel class of anti-CD20 monoclonal antibodies comprising a homogeneous population of anti-CD20 IgG molecules having the same N-glycan on each of Fc. The antibodies of the invention can be produced from anti-CD20 monoclonal antibodies by Fc glycoengineering. Importantly, the antibodies of the invention have improved therapeutic values with increased ADCC activity and increased Fc receptor binding affinity compared to the corresponding monoclonal antibodies that have not been glycoengineered.
Owner:ACAD SINIC

Antigen binding molecules directed to MCSP and having increased Fc receptor binding affinity and effector function

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human MCSP. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Protofibril selective antibodies and the use thereof

The present invention pertains to the prevention, treatment and diagnosis of neurodegenerative diseases, in particular Alzheimer's disease, and other similar disease. More specifically to high affinity antibodies selective for amyloid beta protein (Aβ) in its protofibril conformation and of IgG class and IgG1 or IgG4 subclass or combinations thereof or mutations thereof, retaining high Fc receptor binding and low C1(CIq) binding, effective in clearance of Aβ protofibrils and with reduce risk of inflammation.
Owner:BIOARCTIC AB

Fusion Protein Comprising an Fc Receptor Binding Polypeptide and an Antigenic Polypeptide for Mediating an Immune Response

The present invention provides a fusion protein comprising an Fc receptor binding polypeptide and an antigenic polypeptide. The fusion peptide may further comprise a linker sequence or hinge portion which joins the Fc receptor biding polypeptide and the antigenic polypeptide. The Fc receptor binding polypeptide typically comprises the CH2 constant domain of a human IgG immunoglobulin. The antigenic polypeptide can be any polypeptide which induces an immune response. Administration of the fusion protein to a subject results in a cytotoxic T lymphocyte response being induced against the antigenic polypeptide provided within the fusion protein. The invention further extends to methods for the treatment of a disease condition in a subject using the fusion proteins of the invention.
Owner:IMMUNOBIOLOGY LTD

Immunomodulatory proteins

A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units; wherein each polypeptide monomer unit comprises an Fc receptor binding portion comprising two immunoglobulin G heavy chain constant regions; wherein each immunoglobulin G heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin G heavy chain constant region of an adjacent polypeptide monomer unit; wherein the polymeric protein does not comprise a further immunomodulatory portion; or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.
Owner:LIVERPOOL SCHOOL OF TROPICAL MEDICINE

Method for determining the glycosylation of an antibody

The invention relates to a method for detecting the binding of an antibody to an Fc receptor present on the surface of a cell as well as to a method for determining the level of glycosylation of an antibody. The invention also relates to a reagent kit for carrying out these methods.
Owner:CISBIO BIOASSAYS

Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Fusion constructs and use of same to produce antibodies with increased Fc receptor binding affinity and effector function

The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Antibodies to Carcinoembryonic Antigen (CEA), Methods of Making Same, and Uses Thereof

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies or variants thereof specific for cell surface or membrane bound human CEA. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Potency assays for antibody drug substance binding to FC receptor

The invention relates to a method of characterizing an antibody, which method is suitable as a potency assay for batch release of a pharmaceutical composition comprising an antibody, specifically for use when applying for marketing authorization for said pharmaceutical composition. The assay provided is a method for determining the potency of a drug product comprising an FcR binding peptide, wherein at least one mechanism of action of the FcR binding peptide of the drug product is mediated through the binding of the FcR binding peptide of the drug product to a Fc receptor, wherein said method comprises determining the binding of the FcR binding peptide of the drug product to an Fc receptor.
Owner:GENMAB AS

Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof

The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal antibodies, including chimeric, primatized or humanized antibodies specific for human EGFR. In addition, the present invention relates to nucleic acid molecules encoding such ABMs, and vectors and host cells comprising such nucleic acid molecules. The invention further relates to methods for producing the ABMs of the invention, and to methods of using these ABMs in treatment of disease. In addition, the present invention relates to ABMs with modified glycosylation having improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.
Owner:ROCHE GLYCART AG

Detection method for serum specificity IgE biological activity and kit adopted by same

InactiveCN103823069AAssess the risk of allergiesAssessing Clinical EffectsBiological material analysisBiological testingFc(alpha) receptorCross-link
The invention provides a detection method for serum specificity IgE biological activity and a kit adopted by the same. The detection method comprises the following steps: adopting a KU812 cell system as indicate cells to induce expression of IgE-Fc receptors; incubating serum of a subject and the KU812 cells to facilitate the combination of sIgE to be detected in the serum and the IgE-Fc receptors on the surfaces of the KU812 cells; adding specific allergens combined with the sIgE on the surfaces of the KU812 cells in order to cross-link the receptors and activate the KU812 cells for degranulation and histamine releasing, and simultaneously promoting CD63 molecules in the cells to be transferred onto the surfaces of the cell membranes; marking anti-CD63 antibodies by fluoresceins for cell immunostaining; adopting a flow cytometry to detect the percentage of the expressing CD63 cells in order to finally determine the activated intensity of the KU812 cells. The detection method has the benefits that the detection method can be used for evaluating the risk degree of allergy when patients contact the allergens, as well as evaluating the clinical effects of specific desensitization treatment.
Owner:TIANJIN MEDICAL UNIV

No mitogen activity anti CD3 small molecular antibody designing method

InactiveCN1891716AMitogen activity was not apparentMitogen activity is evidentMetabolism disorderAntinoxious agentsAmyotrophic lateral sclerosisOrgan transplantation
The invention relates to an engineering method for constructing mini-antibody of non-mitogen anti-human CD3 and its usage. The antibody of CD3 with a minibody structure is constructed by CH1, CH2 region, which contains Fc receptor binding site in the structures without antibodies. The antibody can bind with the antigenic specificity of CD3 of T achroacytes' surface and can initiate immunosuppressive function and meanwhile, there is no obvious activity for promoting the mitogen. The antibody can be used for the prevention and treatment about acute rejection in organ transplantation and the treatment about type I diabetes, amyotrophic lateral sclerosis of spinal cord and other autoimmune diseases.
Owner:ACADEMY OF MILITARY MEDICAL SCI

Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced fc receptor binding

InactiveUS20190389941A1Retained and enhanced bindingEnhanced multimerizationSenses disorderNervous disorderDiseaseHuman proteins
The current invention involves a series of fully recombinant multimerized forms of immunoglobulin Fc which thereby present polyvalent immunoglobulin Fc to immune cell receptors. The fusion proteins exist as both homodimeric and highly ordered multimeric fractions, termed stradomers. The invention involves fusion proteins that bind to FcγRs and complement and that are useful in the treatment and prevention of disease.
Owner:GLIKNIK
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