Novel compounds for the treatment of cancer and diseases associated with angiogenic function. Also disclosed are methods of preparing compounds, pharmaceutical compositions containing these compounds, and packaged products, using these molecules to treat cancer (e.g., leukemia, non-small celllungcancer, colon cancer, CNS cancer, melanoma, ovarian cancer, breast cancer, kidney cancer and prostate cancer), as well as methods for diseases linked to angiogenic function (such as age-related macular degeneration, macular dystrophy, and diabetes), methods for monitoring therapy, methods for constructing gene expression profiles, and methods for modulating cell growth, cell Methods of cycle, apoptosis or gene expression.