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Carried-type active platinum metal bunch, prepn. method and use thereof

A platinum metal and supported technology, which is applied in the field of supported active platinum metal clusters and its preparation, can solve the problems of narrow anti-tumor spectrum, duration of adverse reactions, toxic and side effects, etc., and achieves simple implementation method, solution stability and The effect of spreading the problem

Inactive Publication Date: 2007-02-14
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of cisplatin anticancer drugs are: (1) severe toxic side effects, including nephrotoxicity, gastrointestinal toxicity, ototoxicity and neurotoxicity; (2) low activity to certain tumor cells, such as breast cancer, colon (3) easy to produce drug resistance; (4) low water solubility, difficult to metabolize in the body; (5) must be administered by injection
Although some platinum-based metal anti-tumor complexes have been synthesized and screened, and have been or are being applied clinically, these drugs have a narrow anti-tumor spectrum on the one hand, and on the other hand, have different degrees of adverse reactions and short duration, etc. Therefore, designing, screening, and synthesizing a new generation of high-efficiency, broad-spectrum, low-toxicity, and long-lasting antitumor drugs are still the direction of current efforts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation: According to "Oral vanadium supplementation agent with bimetallic oxide as carrier and its preparation and application method" Ye Ying, Feng Lujia, Zheng Libo, Shen Zhongyue, Han Jie, Chen Zhifei, Li Shanshan. National invention patent authorization announcement number CN 1187091C) method to prepare hydrotalcite.

[0025] 1) Grind the hydrotalcite obtained in the preparatory step to 400 mesh, add water and stir evenly, and make a suspension slurry with a concentration of 10%:

[0026] 2) chloroplatinic acid hexahydrate (H 2 PtCl 6 ·6H 2 O), pre-mixed into 0.5g / L aqueous solution;

[0027] 3) Slowly add the chloroplatinic acid solution in step 2) into the suspension slurry in step 1), then add vitamin C whose molar ratio is 3-times that of chloroplatinic acid, and react at room temperature for 4 hours under a nitrogen atmosphere;

[0028]4) centrifuging the reaction solution obtained in step 3) under a nitrogen atmosphere, washing with water, and centrif...

Embodiment 2

[0031] Preparation: Prepare water according to the method of "A Method for Preparing Double Metal Oxide and Hydrotalcite" (Ye Ying, Li Shanshan, Chen Zhifei, Zheng Libo, Huang Xia, Wu Daidai, Han Jie, Zhang Weirui. National Invention Patent Grant No. CN 1222467C) talc.

[0032] 1) Grind the hydrotalcite obtained in the preparatory step to 500 mesh, add water and stir evenly, and make a suspension slurry with a concentration of 5%:

[0033] 2) chloroplatinic acid with a platinum content of 10% by weight of hydrotalcite is prepared in advance into a 25g / L aqueous solution;

[0034] 3) Slowly add the chloroplatinic acid solution in step 2) into the suspension slurry in step 1), then add sodium borohydride whose molar ratio is 10 times that of chloroplatinic acid, and react at room temperature for 10 hours under a nitrogen atmosphere;

[0035] 4) The reaction solution obtained in step 3) is filtered and separated under an argon atmosphere, washed with water and dehydrated by filt...

Embodiment 3

[0038] 1) Calcining commercially available hydrotalcite at 450°C to obtain a bimetallic oxide, then grinding to 500 mesh, adding water and stirring evenly, to prepare a suspension slurry with a concentration of 1%:

[0039] 2) chloroplatinic acid with a platinum content of 20% by weight of the double metal oxide is prepared in advance into a 50 g / L aqueous solution;

[0040] 3) Slowly add the chloroplatinic acid solution in step 2) into the suspension slurry in step 1), then add potassium borohydride whose molar ratio is 15 times that of chloroplatinic acid, and react at room temperature under an argon atmosphere for 15 hours;

[0041] 4) The reaction solution obtained in step 3) is filtered and separated under an argon atmosphere, washed with water, and centrifuged for dehydration;

[0042] 5) The filter cake obtained in step 4) is vacuum-dried at a temperature lower than 80° C. and crushed to 400 meshes to obtain supported active platinum metal clusters. The content of plati...

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Abstract

A carried active Pt metal family used as forage additive or agricultural chemical, or for preparing the antineoplastic health-care food or medicine is carried by hydrotalcite. Its preparing process features that the intercalation assemblage performance of hydrotalcite and the anionic adsorption performance of bimetallic oxide via laminated structure are used, and said hydrotalcite is used as a miniature reactor to synthesize the carried active Pt metal family.

Description

technical field [0001] The invention relates to a supported active platinum metal cluster and its preparation method and use, in particular to a hydrotalcite-supported platinum metal cluster, its preparation method and use. Background technique [0002] Cancer is a common and frequently-occurring disease that seriously threatens human health. Overcoming cancer has always been a research hotspot attracting worldwide attention. So far, the world has spent more than 30 billion US dollars in cancer prevention, drug development and clinical treatment. In the 1960s, Rosenberg, a professor at Michigan State University in the United States, found that cisplatin had anticancer activity when studying the effect of DC electric field on the growth of Escherichia coli, and through clinical verification, cisplatin had good therapeutic effects on various tumors , thus opening up a new field of research on the anticancer effect of metal platinum complexes. At present, platinum-based antic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K47/02A61K47/34A61P35/00A23L1/30A23L33/16
Inventor 夏枚生靳明建胡彩虹朱兴一熊莉
Owner ZHEJIANG UNIV
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