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Tetrandrine emulsion for injection and its preparing method

A technology of tetrandrine and injection of milk, applied in the directions of anti-inflammatory agents, emulsion delivery, non-central analgesics, etc. Toxic side effects, medical effects and the effect of improving the level of medicine and prolonging the action time

Inactive Publication Date: 2006-08-09
肖春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of the above-mentioned dosage form, such as large dosage, low bioavailability, unsustainable drug effect and difficult production, and provide a drug with low toxic reaction and irritation, long drug effect time, and persistence and targeted low-dose tetrandrine injection emulsion to solve the above problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Dissolve 15.0 g of tetrandrine and 22.5 g of glycerin in water for injection, dissolve 12.0 g of refined soybean lecithin in refined soybean oil, respectively heat to about 55°C, mix well, and first emulsify fractionally in a tissue masher, Then it is emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain tetrandrine injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0039] Dissolve 20.0g of tetrandrine and 25.0g of sorbitol in water for injection, dissolve 10g of refined lecithin in refined corn oil, heat to 70°C respectively, mix well, first fractionally emulsify in a tissue masher, and then The high-speed homogenizer emulsifies to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain tetrandrine injection emulsion.

Embodiment 3

[0041] Dissolve 50.0g of tetrandrine and 55.5g of xylitol in water for injection, dissolve 15.0g of refined lecithin in refined sesame oil, heat to 80°C respectively, mix well, first emulsify fractionally in a tissue masher, and then Emulsified by a high-speed homogenizer to meet the particle size of the preparation. Add water for injection to 1000ml, cool, fill, and sterilize to obtain tetrandrine injection emulsion.

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PUM

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Abstract

The present invention discloses a tetrandrine injection emulsion for effectively curing rheumatism and tumor and relieving pain. Its composition includes 15.0-200.0g of tetrandrine, 50-300g of vegetable oil for injection, 5-20g of emulsifying agent, 20-60g of isoosmotic regulating agent and injection water adding to 1000 ml. Its preparation method includes the following steps: dissolving, heating, uniformly mixing, emulsifying, cooling, filling and sterilizing.

Description

technical field [0001] The invention relates to an emulsion for injection and a preparation method thereof, in particular to a tetrandrine injection emulsion for analgesic, antirheumatic and antitumor drugs and a preparation method thereof. Background technique [0002] Tetrandrine is a kind of alkaloid extracted from the root of Tetragalus fangji (C. , anti-myocardial ischemia and reperfusion injury, anti-arrhythmia; (2) calcium antagonism; (3) anti-inflammatory and immunosuppressive; (4) anti-silicosis and anti-tumor effects; (5) anti-diabetic effects; (6) Anti-free radical damage, etc. Clinically used for antihypertensive, angina pectoris, paroxysmal supraventricular tachycardia, analgesia, silicosis, liver cirrhosis, diabetes, tumors, etc. It is also considered to be a broad-spectrum anti-inflammatory drug of non-steroid hormones, and also has certain immunosuppressive effects. The clinical effect is obvious, and it is a natural biological drug with broad application ...

Claims

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Application Information

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IPC IPC(8): A61K31/4748A61K9/107A61P29/00A61P35/00
Inventor 肖春
Owner 肖春
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