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Hydroypropyl-beta-cyclodextrin inclusion of Rhizoma Zedoariae oil and preparation and preparing method

A cyclodextrin inclusion complex, hydroxypropyl technology, applied in the directions of medical preparations containing active ingredients, antiviral agents, drug combinations, etc., can solve the problems of undiscovered, inability to use injections, hemolysis, etc., and achieve improved stability. the effect of improving bioavailability

Inactive Publication Date: 2003-11-26
董英杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the solubility of β-cyclodextrin is still lower than the injection dissolution requirement, and has side effects such as hemolysis, it cannot be used in injections
After searching, no patents and documents about the inclusion of zedoary oil with hydroxypropyl-β-cyclodextrin were found

Method used

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  • Hydroypropyl-beta-cyclodextrin inclusion of Rhizoma Zedoariae oil and preparation and preparing method
  • Hydroypropyl-beta-cyclodextrin inclusion of Rhizoma Zedoariae oil and preparation and preparing method
  • Hydroypropyl-beta-cyclodextrin inclusion of Rhizoma Zedoariae oil and preparation and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take 0.1g of zedoary oil, dissolve it in 0.5ml of ethanol, take 1g of hydroxypropyl-β-cyclodextrin, dissolve it in 20ml of water for injection, add the ethanol solution of zedoary oil into the HPCD solution drop by drop, stir magnetically at room temperature for 3 hours, Use a 0.45 μm microporous membrane to filter and freeze to obtain a white loose powder, which is confirmed by thin-layer chromatography to form an inclusion compound of zedoary oil and hydroxypropyl-β-cyclodextrin. As determined by gas chromatography, the inclusion rate is 90%.

Embodiment 2

[0036] The clathrate powder obtained in Example 1 was washed with ether, and the ether was evaporated to obtain a white clathrate powder.

Embodiment 3

[0038] Others are the same as Example 1, change the magnetic stirring method to the ultrasonic oscillation method, shake at room temperature for 20 minutes, filter the inclusion solution through a 0.45 μm microporous membrane, freeze-dry the filtrate, and obtain a white loose powder, which is confirmed by thin-layer chromatography. An inclusion complex was formed, and the inclusion rate was 90% as determined by gas chromatography.

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Abstract

The hydroxypropyl-beta-cyclodextrin inclusion of Rhizoma zedoariae oil consists of Rhizoma zedoariae oil and hydroxypropyl-beta-cyclodextrin in the ratio of 1 to 1-100. Rhizoma zedoariae oil dissolved in some organic solvent is added into water solution of hydroxypropyl-beta-cyclodextrin via stirring, and the mixture is freeze dried into water soluble inclusion. The included water solution is ultrafiltered, filtered in 0.22 micron porous film and freeze dried to prepare the freeze dried powder for injection. The present invention may be also used for oral taking and external application to result in antiviral and antibacterial effect.

Description

Technical field [0001] The invention relates to a hydroxypropyl-beta-cyclodextrin inclusion compound of zedoary oil, a preparation and a preparation method. The inclusion compound can be used for injection, oral administration and external application, and has antiviral and anticancer effects. Background technique [0002] Zedoary oil is the plant volatile oil extracted from Curcuma phaeocaulis Valeton. or Curcuma kwangsiensis S.G.Lee et C.F. or Curcuma Wenyujin Y.H.chen et C.Ling from Zingiberaceae. Its quality standard should meet the requirements of Chinese Pharmacopoeia. Cancer, anti-virus, pain relief, antipruritic and other effects, injections, suppositories, and ointments made from zedoary oil have been widely used clinically. [0003] Zedoary oil contains a variety of fat-soluble ingredients, mainly containing terpenoids such as curcumol, which are insoluble in water. The marketed Zedoary oil injection mainly uses some surfactants to help dissolve, such as Tween, etc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/724A61P31/12A61P35/00
Inventor 董英杰艾莉张乃先
Owner 董英杰
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