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Bone repair material for large-volume defect of mandible

A large-volume, mandibular technology, applied in the direction of prosthesis, drug delivery, tissue regeneration, etc., can solve the problems of poor formability, poor scaffold strength, and failure to meet the mechanical performance requirements of mandibular bone repair material scaffolds, etc., to achieve excellent strength and toughness, improving elastic strength and wear resistance, excellent biocompatibility and degradation rate

Active Publication Date: 2022-04-19
JIANGSU YENSSEN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, currently used scaffold materials include bioactive ceramics, which have problems of one kind or another: for example, hydroxyapatite and β-tricalcium phosphate are in powder state, and their formability is poor; natural polymers, such as collagen , silk protein, and chitosan have poor scaffold strength; synthetic polymers, such as polylactic acid, polyglycolic acid, polycaprolactone, etc., are similar to natural polymers and cannot meet the requirements of mandibular bone repair materials. Requirements for the mechanical properties of the bracket

Method used

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  • Bone repair material for large-volume defect of mandible

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of chloropropyl-POSS:

[0028] Add methanol into a three-necked flask with a thermometer and a stirring device, add (3-chloropropyl)trimethoxysilane under stirring, continue to stir to make them fully mixed, then add concentrated hydrochloric acid, after fully stirring, slowly heat up to 40 ℃, 1000r / min stirring reaction for 10d, so that the hydrolysis rearrangement reaction fully proceeds, after the reaction, filter, take the precipitate and wash it several times with methanol, then vacuum dry to obtain chloropropyl-POSS, wherein (3-chloropropyl ) The ratio of trimethoxysilane, methanol and concentrated hydrochloric acid is 0.05-0.065mol: 260-270mL: 8-9mL.

Embodiment 2

[0030] Preparation of zinc silicate powder:

[0031] While stirring, add ethyl orthosilicate to the zinc acetate solution, and after stirring for 20-40 minutes, add ammonia solution drop by drop to adjust the pH value of the mixed solution to 7±0.4, continue stirring for 5 minutes, and then transfer the mixed solution to In a hydrothermal reaction vessel, react at 170°C for 4 hours, cool, centrifuge, remove precipitation, and dry to obtain zinc silicate powder, wherein the molar ratio of zinc to silicon is controlled at 2:1, and the concentration of zinc acetate solution is 5wt% .

Embodiment 3

[0033] Preparation of POSS grafted polycaprolactone:

[0034] Step A. Add the chloropropyl-POSS, hexamethylenediamine, methylhydroquinone and triethylamine prepared in Example 1 into a three-necked flask equipped with a condensing device and a stirring device, stir evenly, and heat the ester at 65°C for 5 hours. Cool to room temperature and filter to obtain grafted POSS, wherein the molar ratio of chloropropyl-POSS, hexamethylenediamine, and triethylamine is 1:2.5:2, and the mass of methylhydroquinone added is the mass of chloropropyl-POSS 0.05% of;

[0035] Step B: Add grafted POSS and caprolactone into a three-necked flask, under nitrogen atmosphere, at 120°C, add stannous octoate, stir for 24 hours, cool down to room temperature, add dichloromethane, stir evenly, then add propanol for precipitation, Filtration, precipitation washed with dichloromethane, centrifugation, repeated 3 times, vacuum-dried to obtain POSS grafted polycaprolactone, wherein, the amount ratio of grafte...

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Abstract

The invention relates to a bone repair material for large-volume defect of mandible, and belongs to the technical field of bone repair. The bone repair material is an organic / inorganic composite material, an organic phase comprises collagen, silk fibroin and toughened polylactic acid, an inorganic phase comprises nano-hydroxyapatite and zinc silicate, and the bone repair material is prepared through the following steps that 1, collagen / silk fibroin-based nano-hydroxyapatite is prepared; step 2, preparation of toughened polylactic acid; and 3, mixing the mixed powder, the zinc silicate powder and the toughened polylactic acid solution, uniformly stirring, freezing at-20 to-10 DEG C for 24-48 hours, freezing at 0 DEG C for 24-48 hours, carrying out vacuum drying, crushing, screening, adding into a mold, and carrying out cold press molding, so as to obtain the bone repair material for the large-volume defect of the lower jawbone. The bone repair material provided by the invention has excellent strength and toughness, and excellent biocompatibility and degradation rate.

Description

technical field [0001] The invention belongs to the technical field of bone repair, and in particular relates to a bone repair material for large-volume mandibular defects. Background technique [0002] Large-volume jaw defects are mostly caused by severe trauma, infection, or tumor resection. Mild cases lead to facial deformities, and severe cases lose physiological functions such as chewing, language, and swallowing, which greatly affect the patient's oral and jaw system functions and natural appearance. and mental health. So far, the problem of repairing large-scale bone defects has not been effectively resolved. Due to the limited source of autologous bone, it will bring pain to patients, while other bone repair materials, such as allogeneic bone, or xenogeneic bone may easily lead to immune problems and disease transmission. Artificial bone repair materials are widely used clinically because of their good compatibility with organisms. [0003] Artificial bone repair ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/22A61L27/18A61L27/12A61L27/02A61L27/50A61L27/54A61L27/58
CPCA61L27/24A61L27/227A61L27/18A61L27/12A61L27/025A61L27/50A61L27/54A61L27/58A61L2430/02A61L2300/412A61L2300/252A61L2400/12A61L2300/102A61L2300/404C08L89/00C08L67/04
Inventor 陶国新
Owner JIANGSU YENSSEN BIOTECH CO LTD
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