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Microenvironment macrophage regulation and control delivery system as well as preparation method and application thereof

A macrophage and delivery system technology, applied in the field of microenvironment macrophage regulation and delivery system and its preparation, can solve problems such as lack, and achieve the effects of reducing toxic side effects, maintaining stable circulation, and reducing drug leakage

Active Publication Date: 2022-04-19
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] To sum up, there is currently a lack of drugs that can effectively avoid non-specific drug absorption by mothers and fetuses, and then achieve specific drug delivery and functional regulation of macrophage cell membranes in the placenta. nanocarrier system

Method used

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  • Microenvironment macrophage regulation and control delivery system as well as preparation method and application thereof
  • Microenvironment macrophage regulation and control delivery system as well as preparation method and application thereof
  • Microenvironment macrophage regulation and control delivery system as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Synthesis of S1, polyacetylimide grafted polyethylene glycol (PEG-PEI)

[0059] Polyethyleneimine-grafted polyethylene glycol (PEG-PEI) was synthesized by a two-step method. First, the terminal hydroxyl groups of monomethyl ether polyglycol were activated with carbonyldiimidazole, and then reacted with the amino groups of polyethyleneimine to generate PEG. -PEI. The specific operation is as follows: weigh monomethyl ether glycol (8.0 g, Mn=2 kDa) into a reaction flask, dry it in vacuum at 80° C. for 6 h, and add THF (60 mL) under an argon atmosphere to dissolve it. Weigh carbonyldiimidazole (CDI, 6.4g) and another reaction bottle, then slowly drop THF dissolved in mPEG-OH into the CDI bottle with a constant pressure dropping funnel, and stir the reaction at room temperature overnight. Distilled water (0.648 mL) was added to inactivate excess CDI and stirring was continued for 30 min. Precipitate the solution into a large amount of cold ether, filter and dry in vacuo t...

Embodiment 2-4， comparative example 1-6

[0080] Compared with Example 1, changing the dosage of polymer, drug and SPIO in step S3 or omitting a certain step in steps S3, S4, S5, S6, S7 can prepare Example 2-4 or Comparative Example 1-6 , see Table 1 below for details:

[0081] Table 1: Examples and comparative examples

[0082]

[0083]

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Abstract

The invention discloses a microenvironment macrophage regulation and control delivery system as well as a preparation method and application thereof. The microenvironment macrophage regulation and control delivery system has a core-shell double-layer structure, and an enzyme substrate polypeptide-PEG modified lipid bimolecular membrane which is subjected to targeted disintegration under the action of an enzyme highly expressed in contact with placenta tissue interstitial fluid is taken as a shell; a drug carrier modified by a marker antibody with high specific expression on the surface of placenta macrophages is used as an inner core, and superparamagnetic ferroferric oxide SPIO nanoparticles, small molecular drugs for regulating and controlling the functions of the placenta macrophages, therapeutic genes or a combination thereof are loaded in the drug carrier. The microenvironment macrophage regulation and control delivery system can effectively avoid non-specific drug absorption of a maternal body and a fetus, and then delivery and function regulation and control of macrophage specific drugs in a placenta are achieved.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a microenvironmental macrophage regulation and delivery system and its preparation method and application. Background technique [0002] Malignant tumors during previous pregnancy are uncommon, but with the delay in the average pregnancy age and the development of assisted reproductive technology in recent years, the incidence of malignant tumors in pregnancy has gradually increased. Pregnancy complicated with malignant tumors has entered the top five causes of maternal death, which has a huge impact on the safety of mothers and children [Feng Ling, He Mengzhou, Wang Shaoshuai. The impact of pregnancy complicated with malignant tumors on maternal deaths[J]. Journal of Practical Obstetrics and Gynecology, 2021 ,37(03):178-180.]. Among the malignant tumors in pregnancy, the most difficult one to deal with is the trophoblastic tumor in the placenta of pregnant women. The path...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/42A61K47/10A61K47/68A61K47/60A61K47/52A61K47/69A61K31/56A61K31/7105A61P15/00A61P35/00B82Y5/00B82Y40/00
CPCA61K9/5192A61K9/5169A61K9/5146A61K47/6801A61K47/60A61K47/52A61K47/6935A61K31/56A61K31/7105A61P15/00A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 郭宇
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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