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A kind of seaweed extract that can effectively relieve skin sunburn and its preparation method and application

A seaweed extract and skin technology, applied in the field of seaweed extract and its preparation, can solve the problems of restricting widespread use, allergic contact dermatitis, etc., and achieve the effects of less pollutants, reducing inflammation, and good physiological effects

Active Publication Date: 2022-07-26
SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sunscreen agents in sunscreen cosmetics mostly contain benzene rings and unsaturated side chains, and adverse reactions such as allergic contact dermatitis sometimes occur after ultraviolet radiation, which limits their wide use to a certain extent.
Most of the clinically available drugs are also used to prevent and treat skin photoaging, such as retinoic acid drugs, isotretinoin, tazarotene, retinol, antioxidants (vitamin C, vitamin E, β -carotene, coenzyme Q10, superoxide dismutase SOD, etc.), depigmentation agents (hydroquinone, arbutin, etc.), exfoliating agents (α-hydroxy acids, β-hydroxy acids, etc.), cytokines (epidermal growth factor EGF, fibroblast growth factor FGF, platelet-derived growth factor PDGF, etc.), natural bio-extracted ingredients (epigallocatechin gallate EGCG, anthocyanins, etc.), trace elements (selenium), sex hormones, etc., for skin tanning There are relatively few preparations and drugs for injury protection

Method used

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  • A kind of seaweed extract that can effectively relieve skin sunburn and its preparation method and application
  • A kind of seaweed extract that can effectively relieve skin sunburn and its preparation method and application
  • A kind of seaweed extract that can effectively relieve skin sunburn and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Take the edible hijiri hijiri that meets the relevant seafood use standards in my country and dry the algal body, wash it with distilled water for 3 to 4 times, dry and pulverize to obtain dry powder. Weigh 200 g of dry powder, add 10 L of distilled water, and boil at 100 °C for 0.5 h. After the extract was cooled, centrifuge at 3000g for 15min. The centrifugal supernatant was suction-filtered (filtered through qualitative filter paper), and the filtrate was filtered through an ultrafiltration membrane with a molecular weight cut-off of 5 kDa to collect the ultrafiltration retentate, concentrated and freeze-dried to obtain the seaweed extract.

[0063] The study found that the seaweed extract prepared in this example has good biocompatibility, no sensitization, no skin photosensitivity reaction, can significantly improve cell apoptosis and necrosis caused by ultraviolet radiation, and reduce dermal inflammation after ultraviolet radiation. Exudation and degradation of ...

Embodiment 2

[0065] Weigh 200g of edible fresh hijiki that meets the relevant standards for the use of seafood in my country, wash with deionized water 3 to 4 times, crush, add 4L of deionized water, and bath in boiling water at 100°C for 4 hours. After cooling, centrifuge at 8000g for 12min. The centrifuged supernatant was then filtered through an ultrafiltration membrane with a pore size of 0.45 μm and a molecular weight cut-off of 3 kDa. The retentate of 3kDa~0.45μm was collected, concentrated and freeze-dried to obtain seaweed extract.

[0066] The study found that the seaweed extract prepared in this example has good biocompatibility, no sensitization, and does not cause skin photosensitivity reaction, can significantly improve the phenomenon of cell apoptosis and necrosis caused by ultraviolet radiation, and reduce dermal inflammatory permeability after ultraviolet radiation. It can degrade collagen and elastic fibers, reduce adverse reactions such as erythema, inflammation, exudati...

Embodiment 3

[0068] Weigh 200 g of edible hijiki sun-dried algal bodies that meet the relevant standards for the use of seafood in my country, soak in distilled water for 30 min, wash for 3 to 4 times, and soak in distilled water for 30 min again. The hijiri algae were crushed, added with 5 L of distilled water, and boiled in boiling water at 100°C for 1 hour. After the extract was cooled, centrifuge at 10,000 g for 10 min. The centrifugal supernatant was suction filtered (filtered through qualitative filter paper), and the filtrate was filtered through an ultrafiltration membrane with a molecular weight cut-off of 5 kDa. The ultrafiltration retentate was collected, concentrated and freeze-dried to obtain seaweed extract.

[0069] The study found that the seaweed extract prepared in this example has good biocompatibility, no sensitization, and does not cause skin photosensitivity reaction, can significantly improve the phenomenon of cell apoptosis and necrosis caused by ultraviolet radiat...

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Abstract

The invention discloses a seaweed extract that can effectively relieve skin sunburn, and a preparation method and application thereof. The preparation method includes the following steps: weighing a certain amount of seaweed, adding 20 to 50 times the volume of water, leaching with boiling water for 0.5 h to 4 h, after cooling, the extract is centrifuged at 3000 g to 10000 g for 10 min to 15 min, and the centrifugation supernatant is successively passed through Suction filtration, ultrafiltration, collection of ultrafiltration retentate, concentration, freeze-drying, that is, it is obtained. The preparation method of the invention can remove components that do not significantly improve the activity of cells irradiated by ultraviolet rays, so that the active components in the seaweed extract that can effectively relieve skin sunburn are highly enriched, thereby improving the physiological efficacy of the seaweed extract and greatly reducing its dosage. The seaweed extract has high safety, can significantly reduce cell apoptosis and necrosis caused by ultraviolet radiation, reduce dermal inflammatory exudation and elastic fiber degradation, and effectively relieve skin UV sunburn.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a seaweed extract that can effectively relieve skin sunburn and a preparation method and application thereof. Background technique [0002] With the destruction of the ozone layer and the long-term excessive exposure of the skin to ultraviolet rays, the incidence of photodermatosis, basal cell carcinoma, and squamous cell carcinoma has increased year by year. Local acute phototoxic dermatitis often occurs after the skin is excessively exposed to ultraviolet rays in sunlight, and it is also prone to trigger polymorphic sun rash, herpes simplex, solar urticaria, erythema multiforme, delayed cutaneous porphyria, and lupus erythematosus. , vitiligo, telangiectasia and sun exposure. Therefore, it is very important to find a variety of measures to effectively reduce the skin damage and carcinogenesis caused by ultraviolet radiation. [0003] External application of sunscreen cosm...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/03A61P17/16A61K8/9711A61Q17/04A61Q19/00A61L15/40A61L26/00
Inventor 陈华孙恢礼潘剑宇蔡冰娜万鹏陈得科
Owner SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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