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Delayed disintegration-type capsule and method for producing same

A manufacturing method and disintegration technology, which can be used in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problem of reducing the degree of freedom of film design, and achieve the effect of easy design and increased degree of freedom.

Pending Publication Date: 2022-01-11
MORISHITA JINTAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are many technologies for delaying disintegration, but these proposals are all improvements of the so-called coating such as the outermost layer or the middle layer of the capsule, and the degree of freedom in the design of the coating is reduced

Method used

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  • Delayed disintegration-type capsule and method for producing same
  • Delayed disintegration-type capsule and method for producing same
  • Delayed disintegration-type capsule and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] (a) Nuclear Liquid: Stirring 47.17 parts by weight of Hydrofin (JC oil made by solar oil: 52 ± 3 ° C), 11.79 parts by weight of H9190: melting point 49 ± 3 ° C) And 3.35 parts by weight of soy lecithin were uniformly dissolved, and 4.69 parts by weight of blue No. 1 was mixed in the resulting solubility to be used as a nuclei.

[0065] (b) Intermediate layer solution: mix 9.30 parts by weight of edible oil (JC oil manufactured by solar oil: 52 ± 3 ° C) and 0.7 parts by weight of soy lecithin as an intermediate layer solution.

[0066] (c) Older solution: mix 17.48 parts by weight of gelatin at 60 ° C [Jellystregth, gel strength): 280 Brony (Bloom)], 4.60 parts by weight of glycerol, 0.92 parts by weight of low methoxy Base (LM) pectin and 85.20 parts by weight of pure water, as the outermost liquid.

[0067]Triple nozzle concentrically with the innermost nozzle of the core with the solution was added dropwise, and the intermediate layer from the nozzle dropwise with mediola...

Embodiment 2 and comparative example 1～2

[0074] Using shown in the following Table 1 were blended in the same manner as in Example 1 formed seamless capsule, the elution experiments carried out in the same essentials. In Example 1, results are figure 2 .

[0075] [Table 1]

[0076]

[0077] The above Examples and Comparative Examples, and figure 2 It found: Examples and Comparative Examples were eluted from the start of the experiment started eluting after about 4 hours pigment, but after the start of the experiment eight hours, the seamless capsule of Comparative Example the dye was eluted dye was seamless capsule of Example elution rate of about 2 times, then opened the gap continued. Comparative Example 1 were free of nuclear seamless capsule soy lecithin Comparative Example 2 shows the blending amount of soy lecithin was 2.01 parts by weight of the low amount of experimentation. The blending amount of soybean lecithin in Example 1 was 3.35 parts by weight, from figure 2 Point of view, we can see there is a big gap ...

Embodiment 3

[0079] (A) a liquid nucleus: JC stirring 47.17 parts by weight of oil at 60 ℃, 11.79 parts by weight of edible fat (IOI Oleo manufactured Witocan42 / 44: mp 43 ± 3 ℃) and 3.35 parts by weight of soybean lecithin were dissolved in a uniform, mixing 4.69 parts by weight loxoprofen sodium hydrate (CAS80382-23-6) the resulting lysate, the resulting suspension to a solution as a core.

[0080] (B) a liquid for intermediate layer: mixing 4.65 parts by weight of oil-JC, parts of the Witocan42 / 44 and 0.7 parts by weight of soybean lecithin 4.65 wt., Liquid for the intermediate layer.

[0081] (c) Older solution: mix 17.48 parts by weight of gelatin at 60 ° C [Jellystregth, gel strength): 280 Brony (Bloom)], 4.60 parts by weight of glycerol, 0.92 parts by weight of low methoxy Base (LM) pectin and 85.20 parts by weight of pure water, as the outermost liquid.

[0082] Was added dropwise from an inner nozzle of concentric triple nozzle with the core liquid, and the nozzle from a solution o...

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Abstract

An object of the present invention is to provide a technique for delaying the disintegration of a capsule by blending a certain component into the core of the capsule and to increase the degree of freedom in capsule design. The present invention relates to a seamless capsule and a method for producing the same. The seamless capsule comprises a core, one or more intermediate layers formed on the core, and an outermost layer formed on the intermediate layer, wherein in the delayed disintegration-type seamless capsule, the core contains an active substance, an amphoteric surfactant, and a fat / oil having a melting point of 40 DEG C or higher, at least one of the intermediate layers contains a fat / oil having a melting point of 45 DEG C or higher, and the outermost layer contains a water-soluble natural polymer.

Description

Technical field [0001] The present disclosure relates to a method for producing the seamless capsule and, more specifically, relates to the above method can delay disintegration of the capsule-type delay disintegrating seamless capsule manufacturing seamless capsules and the delayed disintegration. Background technique [0002] Ease of manufacturing or the like viewpoint of ease of particle size control point of view, the seamless capsules are used for various purposes. In particular, it sealed beneficial bacteria like bifidobacteria sealed capsule or the like menthol flavor capsules and the like are commercially available. Study of release time to use these to control the contents of the seamless capsule (also called "core" or "nucleating agents".) A. [0003] Japanese Patent No. 5102401 (Patent Document 1) proposes a seamless capsule, which is specifically disintegrated in the colon. Further, Japanese Patent Laid-Open Publication No. 2014-139200 (Patent Document 2) proposes a c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/36A61K47/42A61K47/44A61K47/24A61K45/00A61K35/744
CPCA61K9/4866A61K9/4858A61K45/00A61K35/744A61K31/192A61K36/00A61K9/5073A61K9/5057A61K9/5005A61K9/5015A61K9/5036A61K9/5089A61K47/24A61K47/44A61K9/4816A61K9/4825A61K9/4833A61K31/19A61K31/375
Inventor 西川雄大石井贺津俊高桥一真
Owner MORISHITA JINTAN CO LTD
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