Anti-coagulation hydrogel material for inducing NO release as well as preparation method and application thereof

Abstract

The invention discloses an anti-coagulation hydrogel material capable of inducing NO release as well as a preparation method and application thereof. The anti-coagulation hydrogel material capable of inducing NO release is obtained by that heparin is grafted to the tail end of six-arm polyethylene glycol to obtain the anti-coagulation hydrogel material, then selenocystamine is further grafted to heparin molecules to obtain the anticoagulant hydrogel material capable of inducing NO release. Therefore, the anticoagulant hydrogel material for inducing NO release is obtained. The anticoagulant hydrogel material for inducing NO release prepared by the method disclosed by the invention has excellent water absorption performance, the hydrogel material has good anticoagulant performance due to introduced heparin molecules, and grafted selenocystamine can catalyze an endogenous NO donor in blood to release NO molecules, so that the effect of promoting vascular endothelial repair is achieved.

Description

technical field [0001] The invention relates to an anticoagulant hydrogel material capable of inducing NO release, its preparation method and application, and belongs to the field of biomedical polymer materials. Background technique [0002] Cardiovascular and cerebrovascular diseases are still the leading cause of death in the world. For completely occluded vascular diseases, the use of autologous arterial or venous grafts for bypass surgery, or complete replacement of occluded vessels to restore blood supply, is a commonly used clinical treatment However, due to the limited source of autologous blood vessels and the possibility of new trauma, its clinical application is greatly limited. Therefore, the use of artificial vascular grafts to replace occluded blood vessels has always been a research hotspot and difficulty in the treatment of cardiovascular diseases. Currently applied synthetic vascular grafts (such as expanded PTFE, Dacron, etc.) show satisfactory long-term pe...

AI Technical Summary

Problems solved by technology

At present, metal implantation / interventional devices (such as vascular stents) are commonly used clinically, but their biocompatibility has not yet met the ideal requirements. For example, late thrombosis and restenosis after stent implantation seriously affect its clinical treatment effect

Although drug-eluting stents based on polymer materials have played a positive role in the treatment of stenotic cardiovascular diseases, their effects are still poor, mainly because the anti-proliferative drugs released by drug carriers play an important role in inhibiting neointimal hyperplasia. At the same time, it also inhibits the growth of vascular endothelial cells. The carrier material itself does not have the effect of anticoagulant and promoting endothelial repair, and it is easy to cause clinical complications such as late thrombosis. Functional layer is currently an effective means to improve the biocompatibility and clinical performance of materials

[0004] Six-armed polyethylene glycol is a synthetic high molecular polymer with good biocompatibility, which is widely used in the fields of biomaterials and tissue engineering, and has potential applications in the surface coating of artificial blood vessels and vascular stents, but Its anticoagulant properties need to be improved, and its ability to promote vascular endothelial repair is limited due to its excellent anti-biofouling ability and ability to prevent protein adsorption

In the prior art and reports, although there are reports on the combined application of heparin and selenocystamine to promote vascular endothelial repair, most of them are used for surface graft modification of materials, and selenocystamine is introduced into heparin-modified six-arm Polyethylene glycol materials, thus preparing hydrogel materials with the ability to promote endothelial repair, has not yet been reported

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