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Modified lauromacrogol foam hardening agent as well as preparation method and application thereof

A technology of foam hardening agent and lauromacrogol, which is applied in general/multifunctional contrast agents, pharmaceutical formulations, photodynamic therapy, etc., to achieve good therapeutic effects, reduce the number of treatments, and improve the effect of uniform dispersion

Pending Publication Date: 2021-07-23
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to overcome the deficiencies in the prior art, provide a kind of modified lauromacrogol foam hardening agent and preparation method thereof, and its application in varicose vein medicine or tumor ablation medicine, solve above-mentioned background technology The problem of the combination and efficacy of lauromacrogol foam sclerosing agent and auxiliary preparations also solves the application problem of lauromacrogol foam sclerosing agent in combination therapy

Method used

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  • Modified lauromacrogol foam hardening agent as well as preparation method and application thereof
  • Modified lauromacrogol foam hardening agent as well as preparation method and application thereof
  • Modified lauromacrogol foam hardening agent as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1) a kind of agar powder modified lauromacrogol-ICG foam hardening agent, preparation method comprises the steps:

[0049] (a) Weigh 0.5g agar powder and 2.5g lauromacrogol crude drug and join in the autoclave of ultra-stable homogeneous formulation device;

[0050] (b) Pressurize to 15Mpa, after the temperature and pressure are stable, stir for 1 hour, and after decompression, collect the lauromacrogol stock solution modified by the auxiliary preparation from the nozzle.

[0051] (c) Dispersing the lauromacrogol bulk drug in an ICG solution dissolved in 5% ethanol aqueous solution to prepare a modified lauromacrogol-ICG composite preparation, wherein the concentration of lauromacrogol is 1%, and the concentration of ICG is 50 μg / mL;

[0052] (d) The preparation of the foam hardener was carried out using the Tessari basic method. Two 10mL syringes were used to extract 8mL of air sterilized by a 0.22μm air disinfection filter and 2mL of modified lauromacrogol-ICG compou...

Embodiment 2

[0057] The difference between embodiment 2 and embodiment 1 is:

[0058] 1) a gelatin-modified lauromacrogol-ICG foam hardening agent, the preparation method may further comprise the steps:

[0059] (a) Weigh 0.5g gelatin and 2.5g lauromacrogol crude drug and join in the autoclave of ultra-stable homogeneous formulation device;

[0060] (b) Pressurize to 15Mpa, after the temperature and pressure are stable, stir for 1 hour, and after decompression, collect the lauromacrogol stock solution modified by the auxiliary preparation from the nozzle.

[0061] (c) Dispersing the lauromacrogol bulk drug in an ICG solution dissolved in 5% ethanol aqueous solution to prepare a modified lauromacrogol-ICG composite preparation, wherein the concentration of lauromacrogol is 1%, and the concentration of ICG is 50 μg / mL;

[0062] (d) The preparation of the foam hardener was carried out using the Tessari basic method. Two 10mL syringes were used to extract 8mL of air sterilized by a 0.22μm ai...

Embodiment 3

[0067] (1) the preparation method of the lauromacrogol-DOX foam hardening agent of gelatin modification among the present invention comprises the following steps:

[0068] (a) Weigh 0.5g gelatin and 2.5g lauromacrogol crude drug and join in the autoclave of ultra-stable homogeneous formulation device;

[0069] (b) Pressurize to 15Mpa, after the temperature and pressure are stable, stir for 1 hour, and after decompression, collect the lauromacrogol stock solution modified by the auxiliary preparation from the nozzle.

[0070] (c) Dispersing the lauromacrogol bulk drug in a DOX solution dissolved in 5% ethanol aqueous solution to prepare a modified lauromacrogol-DOX composite preparation, wherein the concentration of lauromacrogol is 1%, and the concentration of DOX is 100 μg / mL;

[0071] (d) The preparation of the foam hardener was carried out using the Tessari basic method. Two 10mL syringes were used to extract 8mL of air sterilized by a 0.22μm air disinfection filter and 2m...

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Abstract

The invention discloses a modified lauromacrogol foam hardening agent as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, mixing a lauromacrogol bulk drug with gelatin or agar powder with surface activity and foam stabilizing effect through an ultra-stable homogeneous formula technology to prepare a modified lauromacrogol mother solution, and obviously improving the foam stability and defoaming time of the foam hardening agent prepared from the modified lauromacrogol mother solution; subjecting the modified lauromacrogol mother liquor and various active ingredients including a preparation with a photosensitive (thermal) characteristic, a nuclear magnetic resonance imaging preparation, a chemotherapeutic drug, nuclide and the like to ultrasonic mixing to obtain a multifunctional improved lauromacrogol mixed preparation, and then preparing the multifunctional and visual lauromacrogol foam hardening agent under the action of a three-way valve device. The modified lauromacrogol foam hardener for varicose veins and tumors is locally administered in a minimally invasive mode, and then a good treatment effect on the varicose veins and the tumors is achieved in combination with a sclerotherapy and other therapies.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a modified lauromacrogol foam hardening agent and a preparation method thereof, as well as its application in varicose vein medicine or tumor ablation medicine. Background technique [0002] Varicose veins is a clinically common disease of the venous system. Varicose veins can occur in many parts of the body. For example, hemorrhoids are a type of varicose veins. Clinically, there are also varicose veins of the lower extremities and esophageal varices of the gastric fundus caused by liver cirrhosis. . For varicose veins of the lower extremities, the traditional treatment method is high ligation and stripping. Although it achieves a certain therapeutic effect, the high recurrence rate and low patient compliance limit its clinical application. With the continuous development of minimally invasive technology, the treatment of varicose veins has enter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/765A61K9/00A61K41/00A61K47/36A61K47/42A61K45/06A61K49/00A61P9/14A61P35/00
CPCA61K31/765A61K41/0052A61K41/0057A61K9/0019A61K47/36A61K47/42A61K45/06A61P9/14A61P35/00A61K49/0002A61K49/0034A61K2300/00
Inventor 刘刚代奇轩陈虎楚成超毛景松赵庆亮
Owner XIAMEN UNIV
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