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Degradable shape memory medical splint and preparation method thereof

A splint and memory technology, applied in the field of degradable shape memory poly medical splint and its preparation, can solve the problems of affecting the softening properties of materials, complex preparation process, reducing the mechanical properties of materials, etc.

Active Publication Date: 2021-04-06
山东志瑞生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor strength of polycaprolactone itself and the large degree of shrinkage and deformation after crosslinking, it needs to be reinforced by blending with high-strength polymer materials such as polylactic acid, and usually requires the addition of components such as coupling agents and inorganic fillers. Improve compatibility and mechanical properties (CN109608842A, CN102430156A, CN108659483A, CN10169874B, CN102387818B)
However, the addition of high melting point polymers such as polylactic acid may affect the softening performance of the material at low temperature on the one hand, and on the other hand complicate the preparation process of the material
In addition, the cross-linking and curing of polycaprolactone medical splints usually use high-energy electron beams or gamma rays. These high-energy rays may cause the main chain of polycaprolactone to break and degrade, reduce the mechanical properties of the material, and affect the effect of splint fixation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 95 parts by weight of poly(4-hydroxybutyrate) (M n =100kDa), 5 parts by weight of methyl vinyl ketone were stirred in a high-speed mixer for 10min and mixed evenly, then added to a twin-screw extruder and melted and extruded at 80°C at a speed of 50rpm, and extruded to obtain a sheet with a thickness of 2mm. It is perforated with a hole diameter of 2mm. Irradiate with a 254nm ultraviolet lamp for 30 minutes, and the irradiation intensity is 120W / cm 2 , get a medical splint. Its elastic modulus, deformation recovery rate and shrinkage force are shown in Table 1.

Embodiment 2

[0020] 98 parts by weight of poly(4-hydroxybutyrate) (M n =200kDa), 2 parts by weight of azobisisobutyronitrile were stirred in a high-speed mixer for 10min and mixed evenly, added to a twin-screw extruder and melted and extruded at 80°C, with a rotating speed of 80rpm, and extruded to obtain a plate with a thickness of 2mm. It is perforated with a hole diameter of 2mm. Irradiate with 365nm ultraviolet lamp for 1h, and the irradiation intensity is 180W / cm 2 , get a medical splint. Its elastic modulus, deformation recovery rate and shrinkage force are shown in Table 1.

Embodiment 3

[0022] 99 parts by weight of poly(4-hydroxybutyrate) (M n =300kDa), 1 part by weight of di-tert-butyl peroxide was stirred in a high-speed mixer for 15min and mixed uniformly, added to a twin-screw extruder and extruded at 80°C, the rotating speed was 100rpm, and the extruded thickness was 2mm. It is perforated with a hole diameter of 2mm. Irradiate with 254nm ultraviolet lamp for 1h, and the irradiation intensity is 200W / cm 2 , get a medical splint. Its elastic modulus, deformation recovery rate and shrinkage force are shown in Table 1.

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PUM

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Abstract

The invention provides a degradable shape memory medical splint and a preparation method thereof. A medical splint material provided by the invention is prepared by melt blending of 95-99.9 parts by weight of poly (4-hydroxybutyrate) and 0.1-5 parts by weight of cross-linking assistant, extruding into sheets, punching, and ultraviolet irradiation. Compared with a currently used polycaprolactone medical splint, the medical splint provided by the invention is higher in strength and deformation recovery rate and smaller in retraction force, so that the medical splint is better in fixing effect and higher in comfort.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a degradable shape-memory poly(4-hydroxybutyrate) medical splint and a preparation method thereof. Background technique [0002] Clinically, patients need external fixation after fracture or orthopedic surgery to avoid secondary injury. Although gypsum splints are cheap, they have high density, poor air permeability, long curing time, complicated operation, no secondary molding, and poor X-ray transparency, which is not conducive to timely observation of postoperative recovery of patients and brings a lot of inconvenience to treatment . Some shape-memory polymer medical splint materials based on trans-polyisoprene rubber and polyurethane developed in recent years have made great progress compared with gypsum splints, but they are not degradable after being discarded, and easily cause environmental pollution (CN105771002A, CN107415374B , CN108084394B). At present, the main body o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08K5/07C08K5/315C08K5/14C08J5/18C08J7/12
CPCC08J5/18C08J7/123C08J2367/04C08K5/07C08K5/315C08K5/14
Inventor 李志波沈勇阚泽
Owner 山东志瑞生物科技有限公司
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