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Antibacterial medical biological material and preparation method thereof

A technology of biomaterials and matrix materials, applied in the field of antibacterial medical biomaterials and its preparation, can solve problems such as chain complications, bacterial adhesion, infection, etc., and achieve the effect of improving moisturizing function

Active Publication Date: 2020-07-17
B J ZH F PANTHER MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the clinical application of acellular SIS matrix materials, the possible infection is still a very difficult clinical problem. Therefore, the acellular SIS matrix material itself does not have antibacterial and antibacterial capabilities, and it is easy to cause bacteria on its surface. Adhesion, leading to related infection and chain complications

Method used

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  • Antibacterial medical biological material and preparation method thereof
  • Antibacterial medical biological material and preparation method thereof

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preparation example Construction

[0049] Another aspect of the present invention provides a method for preparing an antibacterial medical biomaterial, comprising:

[0050] a) placing the acellular small intestinal submucosa matrix material in a sodium hydroxide solution containing sulfadiazine, controlling the pH of the solution to be between 7.1 and 13.0, and obtaining an intermediate material coated with sulfadiazine sodium on the surface and / or inside;

[0051] b) After the intermediate material obtained in step a is taken out from the solution, washed with sodium chloride solution, and dried, the intermediate material is soaked in silver nitrate solution, so that the sodium ions on the sodium sulfadiazine molecule are The silver ion substitution in silver nitrate is used to obtain the decellularized small intestinal submucosa matrix material loaded with silver sulfadiazine;

[0052] c) performing surface plasma treatment on the acellular small intestinal submucosa matrix material loaded with silver sulfadi...

Embodiment 1

[0075] A method for preparing an antibacterial medical biomaterial, comprising:

[0076] (1) Immerse the small intestinal submucosa tissue material on the pig body into normal saline for cleaning, put the cleaned small intestinal submucosa tissue material into a closed container, freeze-dry it in liquid nitrogen, seal it, and sterilize it For storage, the freeze-drying temperature is -75°C, and the freeze-drying time is 25 hours. The sterilization is to irradiate the sealed small intestinal submucosa tissue material with a radiation dose of 8000 rads and sterilize it through linear acceleration.

[0077] (2) Treat the small intestinal submucosa tissue material obtained in step a1 with decellularization solution in two ultrasonic frequency environments with different frequencies, and perform decellularization; wherein, the decellularization solution includes trypsin and PBS solution, and the decellularization solution The mass percent concentration of trypsin in the medium was ...

Embodiment 2

[0089] A method for preparing an antibacterial medical biomaterial, comprising:

[0090] (1) Immerse the small intestinal submucosa tissue material on the pig body into normal saline for cleaning, put the cleaned small intestinal submucosa tissue material into a closed container, freeze-dry it in liquid nitrogen, seal it, and sterilize it For storage, the freeze-drying temperature is -78°C, and the freeze-drying time is 25 hours. The sterilization is to sterilize the sealed small intestinal submucosa tissue material through linear acceleration and irradiation with a radiation dose of 8000 rads.

[0091] (2) Treat the small intestinal submucosa tissue material obtained in step a1 with decellularization solution in two ultrasonic frequency environments with different frequencies, and perform decellularization; wherein, the decellularization solution includes trypsin and PBS solution, and the decellularization solution The mass percent concentration of trypsin in the medium is 0....

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Abstract

The invention discloses an antibacterial medical biological material and a preparation method thereof. The medical biological material comprises an acellular small intestine submucosa matrix material,an antibacterial gel layer positioned on the surface of the acellular small intestine submucosa matrix material, and an absorbable fiber layer positioned on the surface of the antibacterial gel layer, and sulfadiazine silver is dispersed on the surface of the acellular small intestine submucosa matrix material and / or in the acellular small intestine submucosa matrix material; and the absorbable fiber layer comprises absorbable fibers to which the sulfadiazine silver is attached, and the content of the sulfadiazine silver in the absorbable fibers is 1-2 wt.%. The medical biological material provided by the invention can be widely used as an external medicine for treating secondary wound infection of burns or scalds; and a traditional central venous catheter can be coated with a sulfadiazine silver antibacterial coating to reduce the occurrence rate of infection, so that the medical biological material loaded with the sulfadiazine silver also has antibacterial activity consistent with that of the sulfadiazine silver.

Description

technical field [0001] The invention belongs to the technical field of medical biological materials, and in particular relates to an antibacterial medical biological material and a preparation method thereof. Background technique [0002] Defects and partial or total loss of functions of certain tissues or organs of the body caused by various diseases and traumas are one of the main hazards faced by human health. Research and development of ideal materials for tissue repair has always been an important topic in the fields of medicine, bioscience, and material science. At present, among the many medical biomaterials used in clinic for tissue repair, implantable medical biomaterials are transformed from traditional non-absorbable materials to degradable new biomaterials that can actively induce tissue regeneration. Based on the principle of tissue engineering, extracellular matrix (ECM) materials based on animal tissues are the main development direction. [0003] In the cli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/20A61L27/22A61L27/36A61L27/52A61L27/54
CPCA61L27/3629A61L27/3687A61L27/3691A61L27/20A61L27/18A61L27/22A61L27/54A61L27/52A61L2430/34A61L2300/104A61L2300/404C08L1/284C08L1/286C08L1/04A61K33/38A61L27/58A61L2400/18A61L27/34A61L15/20A61L15/40A61L15/44A61L24/0005A61L24/0015A61L2300/216A61L27/02
Inventor 刘青
Owner B J ZH F PANTHER MEDICAL EQUIP
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