Metal-ICG complex, preparation method of complex, metal-ICG complex albumin nanoparticles and preparation method and application of nanoparticles

A technology of albumin nanoparticles and complexes, which is applied in pharmaceutical formulations, non-active ingredients of polymer compounds, and medical preparations containing active ingredients, etc., can solve the problems of narrow treatment window, short irradiation wavelength, and few types of sonosensitizers. , to achieve the effect of convenient operation, reduced preparation cost, and broadened irradiation wavelength

Inactive Publication Date: 2020-07-03
SHENZHEN INST OF ADVANCED TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0004] One of the objectives of the present invention is to provide a metal-ICG complex to improve the existing technical problems of few types of sound sensitizers, short maximum irradiation wavelength and narrow therapeutic window

Method used

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  • Metal-ICG complex, preparation method of complex, metal-ICG complex albumin nanoparticles and preparation method and application of nanoparticles
  • Metal-ICG complex, preparation method of complex, metal-ICG complex albumin nanoparticles and preparation method and application of nanoparticles
  • Metal-ICG complex, preparation method of complex, metal-ICG complex albumin nanoparticles and preparation method and application of nanoparticles

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preparation example Construction

[0038] According to the second aspect of the present invention, the present invention provides a method for preparing a metal-ICG complex, comprising the following steps: uniformly mixing an ICG solution and a metal salt solution, and ultrasonicating to obtain a metal-ICG complex.

[0039] In the present invention, "-" in the metal-ICG complex represents "and".

[0040] In the present invention, by mixing the metal salt and ICG solution and performing ultrasonication, the metal ion and ICG are complexed with coordination bonds, the process is simple, the operation is convenient, and the physiological function of the metal ion in the living body can be exerted while optimizing the structure of ICG. function, which not only improves the stability of ICG in the body, but also broadens the irradiation wavelength and expands the treatment window.

[0041] In the present invention, a metal salt is a salt that can dissociate metal ions.

[0042] In a preferred embodiment of the pres...

Embodiment 1

[0075] This embodiment provides a Mn-ICG complex, which is prepared according to the following steps:

[0076] (1) Dissolve 10 mg of ICG in 10 mL of N,N-dimethylformamide (DNF) to obtain an ICG solution;

[0077] (2) 5 mg of manganese acetate tetrahydrate was dissolved in 5 mL of methanol solution to obtain a manganese acetate solution;

[0078] (3) Add manganese acetate solution to the ICG solution, monitor the progress of the reaction by ultraviolet (UV), stop the reaction after 1.5h, add 50-60mL saturated saline to the reaction system, refrigerate overnight, collect the precipitate, freeze-dry to obtain Mn -ICG complexes.

Embodiment 2

[0080] This example provides a Mn-ICG complex, which differs from Example 1 in that in step (2), the amount of manganese acetate tetrahydrate is 2.5 mg.

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Abstract

The present invention provides a metal-ICG complex, a preparation method of the complex, metal-ICG complex albumin nanoparticles and a preparation method and application of the nanoparticles, and relates to the technical field of nano-drugs. Metal ions of the metal-ICG complex are selected from at least one of gold, platinum, zinc, copper, cobalt, iron, nickel and manganese. The technical problemsof few types, short maximum illumination wavelength and narrow therapeutic window of an existing acoustic sensitive agent are improved; and the metal ions and ICG in the metal-ICG complex provided bythe invention are complexed by coordination bonds, so that the type of acoustic sensitive agents is expanded, the illumination wavelength of the acoustic sensitive agents is increased, the therapeutic window is extended, and the metal-ICG complex has double functions of photosensitivity and acoustic sensitivity and can effectively promote the development of photothermal and sonodynamic therapy.

Description

technical field [0001] The invention relates to the technical field of nanomedicine, in particular to a metal-ICG complex and a preparation method, a metal-ICG complex albumin nanoparticle, a preparation method and an application. Background technique [0002] Sonodynamic therapy (SDT) is to kill tumors by chemically reacting with water molecules or oxygen molecules in the environment to generate singlet oxygen and free radicals and other reactive oxygen species (ROS) through sound sensitizers excited by ultrasound. cells for the purpose of treating tumors. SDT is a new method for deep treatment of tumors developed on the basis of photodynamic therapy. Compared with photodynamic therapy, SDT has the advantages of deep penetration and non-invasiveness. Currently, sonosensitizers still have disadvantages such as few types, short maximum irradiation wavelength, and narrow therapeutic window. Therefore, it is necessary to develop new sonosensitizers with longer wavelengths to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/42A61P35/00
CPCA61K9/5169A61K41/0033A61K41/0052A61P35/00A61K2300/00
Inventor 蔡林涛陈华清马爱青梁锐晶刘兰兰张升平郑明彬
Owner SHENZHEN INST OF ADVANCED TECH
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