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Method for preparing high-purity natural capsaicin monomer

A technology of natural capsaicin and capsaicin, applied in organic chemical methods, carboxylic acid amide separation/purification, organic chemistry, etc., can solve the problems of unsuitability for industrial production, high production cost, and high toxicity of solvents, and achieve the yield of finished products High, low equipment requirements, good product quality

Inactive Publication Date: 2020-05-22
海山都(上海)生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing capsaicin monomer separation method comprises as solvent extraction method, supercritical carbon dioxide fluid extraction method, high-speed countercurrent chromatography, ion-exchange resin method, silica gel normal phase chromatography, reverse phase C18 method etc., but above various methods respectively There are problems such as high solvent toxicity, small processing capacity, cumbersome process, and high production cost, which are not suitable for industrial production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A method for separating high-purity capsaicin monomer from natural capsaicin compounds, the steps are:

[0025] (1) Grinding: get 10g capsaicin crude product, use grinder to grind 10g capsaicin crude product into powder;

[0026] (2) alcohol-soluble: the crude product natural capsaicin (capsaicin content 75%) that will be ground into powder in step (1), be dissolved in 100ml66% ethanol aqueous solution, filter for subsequent use;

[0027] (3) sample loading adsorption: the crude product natural capsaicin solution after filtering in step (2) is pumped in 500 milliliters of HST-RPC-01 adsorption resin columns with 0.5CV / h;

[0028] (4) Chromatographic elution: after the loading of the crude product natural capsaicin solution in step (3) is finished, then the above-mentioned resin column is eluted with 1CV / h with 55% aqueous ethanol solution, and the 1.5~3.5CV eluate is collected first It is the qualified eluent of capsaicin, and then collect 3.5 ~ 6.5CV eluent to be the ...

Embodiment 2

[0031] A method for separating high-purity capsaicin monomer from natural capsaicin compounds, the steps are:

[0032] (1) Grinding: get 8g capsaicin crude product, use grinder to grind 8g capsaicin crude product into powder;

[0033] (2) alcohol-soluble: the crude product natural capsaicin (capsaicin content 65%) that will be ground into powder in step (1), be dissolved in 100ml60% ethanol aqueous solution, filter for subsequent use;

[0034] (3) sample loading adsorption: the crude product natural capsaicin solution after filtering in step (2) is pumped in 500 milliliters of HST-RPC-01 adsorption resin columns with 0.5CV / h;

[0035] (4) Chromatographic elution: after the loading of the crude product natural capsaicin solution in step (3) is finished, then the above-mentioned resin column is eluted with 1CV / h with 55% aqueous ethanol solution, and the 1.5~3.5CV eluate is collected first It is the qualified eluent of capsaicin, and then collect 3.5 ~ 6.5CV eluent to be the el...

Embodiment 3

[0038] A method for separating high-purity capsaicin monomer from natural capsaicin compounds, the steps are:

[0039] (1) Grinding: get 10g capsaicin crude product, use grinder to grind 10g capsaicin crude product into powder;

[0040] (2) alcohol-soluble: the crude product natural capsaicin (capsaicin content 55%) that will be ground into powder in step (1), be dissolved in 100ml70% ethanol aqueous solution, filter for subsequent use;

[0041] (3) sample loading adsorption: the crude product natural capsaicin solution after filtering in step (2) is pumped in 500 milliliters of HST-RPC-01 adsorption resin columns with 0.5CV / h;

[0042] (4) Chromatographic elution: after the loading of the crude product natural capsaicin solution in step (3) is finished, then the above-mentioned resin column is eluted with 1CV / h with 55% aqueous ethanol solution, and the 1.5~3.5CV eluate is collected first It is the qualified eluent of capsaicin, and then collect 3.5 ~ 6.5CV eluent to be the ...

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Abstract

The invention discloses a method for preparing a high-purity natural capsaicin monomer. The method comprises the following steps: (1) grinding: taking a certain amount of a capsaicin crude product, and grinding the capsaicin crude product into powder; (2) alcohol dissolution: dissolving the powdery capsaicin-containing crude product obtained in the step (1) in an ethanol water solution, fully stirring for 20-30 minutes to obtain a capsaicin solution, and filtering the capsaicin solution for later use; (3) adsorption: pumping the capsaicin solution filtered in the step (2) into an adsorption resin column; (4) elution: eluting the resin column in the step (3) with an ethanol aqueous solution; and (5) crystallization: concentrating and crystallizing the capsaicin qualified eluent in the step(4) to obtain capsaicin crystals. According to the method for purifying capsaicin, the ethanol aqueous solution is adopted as an elution agent, the process is environmentally friendly, safe and simple, the separation efficiency is high, the finished product yield is high, the product quality is good, the equipment requirement is low, the production period is short, and the cost is effectively reduced.

Description

technical field [0001] The invention belongs to the field of natural product extraction, separation and purification, and specifically relates to a method for preparing high-purity natural capsaicin monomer. Background technique [0002] Capsicum is a food spicy seasoning commonly used in people's daily life; Homodihydrocapsaicin and other homologues. High-purity capsaicin compounds are mainly used in the pharmaceutical industry, and have the functions of analgesia, anti-inflammation, sterilization, and treatment of gastrointestinal diseases and blood cancer. Ointment made of capsaicin has a significant curative effect on chronic rheumatoid arthritis, herpes zoster, bruises and other neuralgia; it has a good therapeutic effect on psoriasis and alopecia; it can prolong the analgesic time and reduce the pain when used in combination with morphine. Addictive, it is the preferred long-acting analgesic drug recommended by the US FDA. [0003] Capsaicin is an extremely pungent ...

Claims

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Application Information

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IPC IPC(8): C07C231/24C07C233/20
CPCC07C231/24C07B2200/13C07C233/20
Inventor 厉留柱宁勇
Owner 海山都(上海)生物技术有限公司
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