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Mongolian medicine sandalwood padauk core medicinal material quality detection method based on high performance liquid chromatograph (HPLC) fingerprint spectrum

A quality detection method and fingerprint technology, applied in the field of quality detection of red sandalwood medicinal materials, can solve the problems of unfavorable actual quality control, prolonging the quality detection cycle, long calculation time, etc., and achieve fast calculation speed, short detection cycle, and detection The effect of high sensitivity

Inactive Publication Date: 2019-07-30
INNER MONGOLIAN AUTONOMOUS REGION INST OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, the quality detection of red sandalwood heart medicinal materials is usually carried out by infrared spectroscopy, but because the infrared spectral data obtained by this method is a spectrogram, it cannot be used in the "Chinese Medicine Chromatographic Fingerprint Similarity Evaluation System (2004A Edition, compiled by the National Pharmacopoeia Committee"). )” software for data processing to calculate the similarity, can only copy the source file data of infrared spectrograms of all red sandalwood samples from the workstation of BRUKER IFS-55 Fourier infrared spectrometer, transfer them to TXT files, and then import them into word. Transfer to Excel to calculate the similarity through a specific calculation formula; therefore, it takes a long calculation time, which prolongs the quality inspection cycle and is not conducive to actual quality control

Method used

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  • Mongolian medicine sandalwood padauk core medicinal material quality detection method based on high performance liquid chromatograph (HPLC) fingerprint spectrum
  • Mongolian medicine sandalwood padauk core medicinal material quality detection method based on high performance liquid chromatograph (HPLC) fingerprint spectrum
  • Mongolian medicine sandalwood padauk core medicinal material quality detection method based on high performance liquid chromatograph (HPLC) fingerprint spectrum

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Experimental program
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Effect test

Embodiment 1

[0040] Instruments and materials:

[0041] Therm3000 high performance liquid chromatography, Thermo Fisher automatic sampler, diode array detector, ultrasonic cleaner: model, KQ3200DV numerical control, Kunshan Ultrasonic Instrument Co., Ltd.; universal high-speed pulverizer, model: FLB-500A, Shanghai Fei Libo Food Machinery Co., Ltd.; ultra-pure water machine, model: XJG-40-B, Shenyang Xinjie Technology Co., Ltd.; electric blast drying oven (Shanghai-Heng Scientific Instrument Co., Ltd.); AL104 electronic balance (Mite Le-Toledo Instrument Co., Ltd.), chromatographic column Thermo C18 (250×4.6mm 5μm); red sandalwood medicinal materials (batch numbers: 20100829, 20100830, 20120920, 1203011), provided by the National Mongolian Medicine Preparation Center; (batch numbers: 20100203, 100501, 20140513), purchased from different local pharmacies; Indian red sandalwood heartwood (batch numbers: 20150618, 20150714), purchased from the Fozhu Market in Hohhot; the control substance was ...

Embodiment 2

[0049] 1. See Table 1 for the sources of samples of red sandalwood medicinal materials used in material experiments.

[0050] Table 1 Mongolian medicine red sandalwood HPLC fingerprint sample batch list

[0051] Red sandalwood medicinal material number Sample serial number batch number source 1 S1 9814104 Provided by the Mongolian Medicine Department of the Inner Mongolia Institute for Food and Drug Control 2 S2 20100203 Bought from Furui Pharmacy Store in Hohhot Origin: Unknown 3 S3 100501 Purchased from Hexiantang Dayao, Hohhot. Real estate location: Hainan 4 S4 20100829 Bought from Shouchuntang Pharmacy in Hohhot Origin: Unknown 5 S5 20100830 National Mongolian Medicine Preparation Center provides origin: Guangdong 6 S6 1203011 National Mongolian Medicine Preparation Center provides origin: Guangdong 7 S7 20140513 Bought from Shouchuntang Pharmacy in Hohhot Origin: Guangdong 8 S8 20150806 Indian r...

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Abstract

The invention discloses a mongolian medicine sandalwood padauk core medicinal material quality detection method based on a high performance liquid chromatograph (HPLC) fingerprint spectrum. The mongolian medicine sandalwood padauk core medicinal material quality detection method comprises the following operation steps: (1) a test solution is prepared; (2) the test solution prepared in the step (1)is injected into HPLC to be detected, and a test chromatogram is obtained; (3) a reference solution is prepared; (4) the reference solution prepared in the step (3) is injected into the HPLC to be detected, and the reference fingerprint spectrum is obtained; and (5) the test chromatogram obtained in the step (2) and the reference fingerprint spectrum obtained in the step (4) are compared, and therelative standard deviation (RSD%) is calculated. The mongolian medicine sandalwood padauk core medicinal material quality detection method can serve as a means of sandalwood padauk medicine true andfalse identification and quality detection, and has the advantages of being safe, reliable and controllable in quality.

Description

[0001] Technical field: [0002] The invention relates to a quality detection method of red sandalwood medicinal material, in particular to a quality detection method of Mongolian medicine red sandalwood medicinal material based on HPLC fingerprint. [0003] Background technique: [0004] As a Mongolian medicinal material, red sandalwood is a high-frequency clinical medicine in Mongolian medicine. Red sandalwood is the powder of the dried heartwood of the butterfly-shaped plant Pterocarpus indicus Willd. It is native to India and Southeast Asia, and it is also cultivated in Yunnan, Hainan and other places in my country; Alias: red sandalwood, rose wood, green dragon wood, red blood tree, etc. Its heartwood is used as the part of medicine, which has the effects of clearing blood heat, regulating "Heyi" blood stasis, and reducing swelling. Clinically, it is mainly used for blood heat, blood stasis and tingling pain, "Heyi" blood conflict, "Baori" fever, liver fire, heart heat, lu...

Claims

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Application Information

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IPC IPC(8): G01N30/86
CPCG01N30/8686G01N30/8696
Inventor 朱明张红霞王静
Owner INNER MONGOLIAN AUTONOMOUS REGION INST OF CHINESE MEDICINE
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