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Traditional Chinese medicine composition and its application in preparation of medicine for treating acute kidney injury

A technology of acute kidney injury and composition, applied in traditional Chinese medicine composition, the application field of medicine, can solve the problems of aggravation, electrolyte balance disorder, lack of specificity, etc., and achieve the effect of improving the level

Active Publication Date: 2021-10-01
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the treatment of diseases requires the use of drugs that may damage the kidneys, such as gentamicin, amikacin, vancomycin, etc., so there are uncertain risk factors, and for the treatment of complications of acute kidney injury, It often leads to electrolyte balance disorder in the body, which in turn aggravates the condition
[0004] At present, there is still a lack of specific therapeutic drugs for acute kidney injury clinically, so it is of great significance to find drugs for the prevention and treatment of acute kidney injury

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Chinese medicine composition

[0021] This embodiment is a traditional Chinese medicine composition for treating acute kidney injury, and its active ingredients are mainly prepared from the following raw materials in parts by weight: 1 part of borneol, 1 part of musk, 4 parts of berberine, 4 parts of scutellaria, and 4 parts of gardenia , 4 parts of turmeric, 2 parts of pearl, 8 parts of concentrated buffalo horn powder, and 4 parts of bezoar.

[0022] The above-mentioned traditional Chinese medicine composition provided in this example can be made into all acceptable preparations such as pills, granules, suppositories, capsules, tablets, dripping pills, oral liquids, injections or powders by adding appropriate auxiliary materials.

Embodiment 2

[0023] Embodiment 2: the method that Chinese medicine composition is prepared into honeyed pill

[0024] Weigh borneol 25g, musk 25g, coptis 100g, scutellaria baicalensis 100g, gardenia 100g, turmeric 100g, pearl 50g, buffalo horn concentrated powder 200g, bezoar 100g nine herbs;

[0025] Pearl water fly or crushed into very fine powder; coptis, scutellaria, gardenia, and turmeric crushed into fine powder; bezoar, buffalo horn concentrated powder, musk, borneol, ground into fine powder, blended with the above powder, sieved, and mixed;

[0026] Add appropriate amount of refined honey (85-95g of refined honey per 100g of traditional Chinese medicine composition) to make large honeyed pills (3g / ball).

Embodiment 3

[0027] Embodiment 3: the effect of the honeyed pill prepared in embodiment 2 on acute kidney injury caused by ischemia-reperfusion

[0028] (1) Test drug

[0029] The Angong Niuhuang Pill (QZX-AGNH) that does not contain cinnabar and realgar obtained in Example 2, properties: this product is a large honeyed pill from yellow orange to reddish brown; manufacturer: Guangzhou Baiyunshan Zhongyi Pharmaceutical Co., Ltd.; storage Method: sealed, protected from light, dry, and stored at room temperature; preparation method: before use, grind it into powder, weigh it, dissolve it in physiological saline, and prepare suspensions with different concentrations.

[0030] (2) Methods and results

[0031] Thirty Kunming mice (20-25g, male) were randomly divided into 3 groups, 12 in each group, namely the sham operation group, the model group and the drug group. Among them, the sham operation group: intragastric administration of the same amount of normal saline; the model group: intraga...

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PUM

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Abstract

The invention provides a traditional Chinese medicine composition and its application in the preparation of medicines for treating acute kidney injury; the active ingredients of the traditional Chinese medicine composition are prepared from the following raw materials in parts by weight: 1-2 parts of borneol, 1-2 parts of musk 3-5 parts of Coptis chinensis, 3-5 parts of Scutellaria baicalensis, 3-5 parts of gardenia, 3-5 parts of turmeric, 1-3 parts of pearl, 7-9 parts of concentrated buffalo horn powder, 3-5 parts of bezoar. The results of pharmacodynamic studies show that the traditional Chinese medicine composition has a significant protective effect on acute kidney injury in mice caused by renal ischemia-reperfusion, vancomycin, and cisplatin, and can significantly reduce blood urea nitrogen caused by renal injury. , serum creatinine, TNF-α and IL-1β increase, reduce serum malondialdehyde and NO content in renal tissue, and increase superoxide dismutase level in renal tissue.

Description

technical field [0001] The invention belongs to the fields of health food and medicine research, and relates to a traditional Chinese medicine composition and its application in preparing medicine for treating acute kidney injury. Background technique [0002] Acute kidney injury refers to a clinical syndrome in which the glomerular filtration rate suddenly or continuously decreases, causing the storage of nitrogenous waste in the body, and the disturbance of water, electrolyte and acid-base balance, resulting in complications of various systems. Acute kidney injury is a common clinical critical disease, with acute onset, rapid disease progression, high mortality and case fatality rate, and the incidence rate is increasing year by year. [0003] The treatment of acute kidney injury mainly includes removing the cause, maintaining a stable internal environment, nutritional support, dealing with complications, and blood purification. Finding the cause and eliminating the cause...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P13/12A61K31/045
Inventor 柴玉爽徐毅敏尹震邹琦何源峰张春波
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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