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Bioactive ceramic fiber composite scaffold for bone repair and preparation method of composite scaffold

A bioactive ceramic and fiber composite technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve problems such as difficult processing, high brittleness, unsatisfactory degradability and biological activity, etc., to improve brittleness, high brittleness, Effect of Cytocompatibility Improvement

Inactive Publication Date: 2019-03-12
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the shortcomings of traditional ceramic scaffold materials such as high brittleness, difficulty in processing and molding, and unsatisfactory degradability and biological activity, the purpose of the present invention is to develop a class of bioactive ceramic fiber porous scaffold materials with excellent mechanical properties and biocompatibility and degradability

Method used

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  • Bioactive ceramic fiber composite scaffold for bone repair and preparation method of composite scaffold
  • Bioactive ceramic fiber composite scaffold for bone repair and preparation method of composite scaffold
  • Bioactive ceramic fiber composite scaffold for bone repair and preparation method of composite scaffold

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Add 7.56g of calcium nitrate tetrahydrate to 15ml of ethanol and ultrasonically dissolve it for 2h, add 800μl of 1mol / L dilute hydrochloric acid solution and 15.14ml of tetraethyl orthosilicate, stir and age in a water bath at 37°C for 3 days to obtain a sol-gel solution.

[0034] (2) Dissolve 1 g of polyvinyl alcohol in 9 g of ethanol to prepare a clear and transparent solution with a concentration of 10 wt.%, mix it with the sol-gel solution prepared in step (1), and stir overnight in a 37° C. water bath with magnetic force.

[0035] (3) Spinning the precursor solution obtained in step (2) by electrospinning process to obtain a fiber membrane, the spinning parameters are: voltage 22kV, receiving distance 15cm, flow rate 0.6ml / h, and the humidity of the environment is controlled at 20±5o, the temperature is 35±2℃.

[0036] (4) Cut 0.2g of the fiber membrane obtained in step (3) into 1*1cm 2 Fragments of different sizes are suspended in 20ml of deionized water, an...

Embodiment 2

[0042] (1) Mix 10ml of triethyl phosphate with deionized water and absolute ethanol at a molar ratio of 1:3:3, hydrolyze at 80°C for 28 hours, and cool to room temperature as a phosphorus source.

[0043] (2) Weigh 7.56g of calcium nitrate tetrahydrate and add it into 15ml of ethanol, and ultrasonically dissolve it for 2 hours as a calcium source.

[0044] (3) Add 15.14ml tetraethyl orthosilicate to the calcium source in step (2), and stir in a water bath at 37°C for 12h until clear and transparent.

[0045] (4) Add the solution in step (3) dropwise to the phosphorus source solution prepared in step (1), and control the molar ratio of feeding calcium to phosphorus to be 1.3. After the dropwise addition was completed, the stirring was continued for 3 h, and then the sol was placed in a water bath at 37° C., and stirred by magnetic force for 3 days for sufficient aging.

[0046] (5) Mix the fully aged gel with water and 5wt.% spinning aid polyvinylpyrrolidone aqueous solution a...

Embodiment 3

[0053] (1) Mix 10ml of triethyl phosphate with deionized water and absolute ethanol at a molar ratio of 1:3:3, hydrolyze at 80°C for 28 hours, and cool to room temperature as a phosphorus source.

[0054] (2) Weigh 6.80g of calcium nitrate tetrahydrate and 0.82g of magnesium nitrate hexahydrate into 15ml of ethanol, and ultrasonically dissolve it for 2 hours.

[0055] (3) Add the solution in step (2) dropwise to the phosphorus source solution prepared in step (1), and control the ratio of calcium to phosphorus to be 1.3. After the dropwise addition was completed, the stirring was continued for 3 h, and then the sol was placed in a water bath at 37° C. and stirred by magnetic force for 3 days to fully age.

[0056] (4) Mix the fully aged gel with 5wt.% spinning aid, that is, polyvinyl butyral solution at a mass ratio of 5:1, and stir magnetically for 24 hours in a water bath at 37°C to obtain a transparent Clear spinning solution. Electrospinning equipment is used for spinnin...

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Abstract

The invention discloses a bioactive ceramic fiber composite scaffold for bone repair and a preparation method of the composite scaffold, and relates to the field of bone repair materials. In order toovercome the shortcomings of large brittleness, difficulty in processing, unsatisfactory degradability and biological activity and the like of a traditional ceramic scaffold material, bioactive ceramics such as calcium silicate serve as a scaffold body, and the surfaces of ceramic fibers are uniformly coated with a layer of degradable biomedical high polymer materials by an impregnation-centrifugation-drying process to obtain a high-porosity, good-mechanical-property and biodegradable bioactive ceramic fiber composite scaffold material for bone repair. The bioactive ceramic materials are easily subjected to synostosis with host bones, inorganic ions released by degrading the bioactive ceramic materials can participate in and promote osteogenesis and even angiogenesis metabolism activity ofa body and have irritating or inducing functions for tissue regeneration repair, and defective bone tissue repair and functional reconstruction are promoted. Degradation products of the biomedical high polymer materials on the surface of the scaffold are harmless and can be excreted to the outside of the body by metabolism.

Description

technical field [0001] The invention relates to the field of bone repair materials, in particular to a bioactive ceramic fiber composite scaffold material with high porosity, good mechanical properties and biodegradability and a preparation method thereof. Background technique [0002] Tissue engineering provides a feasible way for the regeneration and repair of bone tissue damage. It constructs a three-dimensional complex of cells and biomaterials to reconstruct the shape, structure and function of the damaged tissue and achieve permanent replacement. Bone tissue is a very typical inorganic / organic complex, which is combined in a certain way to form strong and tough bone tissue. The inorganic components of normal human bone tissue are mainly calcium phosphate, and some doping elements such as magnesium and manganese, and the organic components are mainly collagen and other proteins. The weight ratio of inorganic components to organic components is about 67% and 33% respecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/34A61L27/50A61L27/56A61L27/58
CPCA61L27/10A61L27/12A61L27/34A61L27/50A61L27/56A61L27/58A61L2420/02A61L2430/02
Inventor 蔡晴杜志云郭立英黎雷郑天宜杨小平
Owner BEIJING UNIV OF CHEM TECH
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