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Preparation for treating skin tumors and neoplasm and preparation method thereof

A technology for skin tumors and neoplasms, applied to skin diseases, anti-tumor drugs, and medical preparations containing active ingredients, etc., can solve the problems of malignant skin tumors spreading, nevus cells cannot be completely eliminated, etc., to achieve Effects of inducing epithelial cell proliferation, broad industrialization prospects, and promoting rapid healing

Inactive Publication Date: 2019-02-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the laser treatment is not good. On the surface, the mole is clean, but in fact it cannot be completely eliminated; repeated laser treatment will make the mole worse.
The method of using drugs to spot moles is not completely removed, and there is also the possibility of malignant transformation after repeated stimulation
Cryogenic and corrosive drugs can not completely eliminate nevus cells, but also easily cause damage to normal tissues; surgery will leave scars and affect the appearance
However, malignant skin tumors are prone to spread of lesions through surgical treatment.

Method used

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  • Preparation for treating skin tumors and neoplasm and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Synthesis of nano single crystal lanthanum boride

[0037]Weigh lanthanum oxide (0.326g) and lithium borohydride (0.26g) powders into a ball mill jar according to the molar ratio of lanthanum and boron at 1:6 (La:B=1:6), and ball mill at 400rpm for 16 hours to obtain The mechanical mixture of lanthanum oxide and lithium borohydride is placed in a reactor, heated from room temperature to 300°C at a heating rate of 2°C / min, and then kept for 2 hours.

[0038] La 2 o 3 +12LiBH 4 →2LaB 6 +3Li 2 O+6LiH+21H 2

[0039] Release hydrogen gas, cool to room temperature and wash with water. During water washing, LiH reacts with water to generate hydrogen and lithium hydroxide. Lithium hydroxide is dissolved in water, centrifuged, and vacuum-dried at 80°C to obtain nano single crystal lanthanum boride.

Embodiment 2

[0040] Example 2: Synthesis of titanium dioxide-coated nano single crystal lanthanum boride

[0041] Add 1 gram of acetic acid and 0.1 gram of tetrabutyl titanate to 90 milliliters of ethanol in sequence, and disperse by ultrasonic wave for 40 minutes to form A solution; add 15 grams of acetic acid to 20 milliliters of ethanol, then add 10 milliliters of deionized water and 2 grams of Nano single-crystal lanthanum boride to form a suspension; after magnetically stirring the solution A at a constant temperature of 30°C for 30 minutes, it was added dropwise to the suspension for coating with titanium dioxide; after stirring for 12 hours, the coating was completed, and centrifuged to obtain Titanium dioxide coated nano single crystal lanthanum boride.

Embodiment 3

[0042] Example 3: Anatase-type titanium dioxide coated nano single crystal lanthanum boride

[0043] Add 1 g of acetic acid and 0.25 g of tetrabutyl titanate to 90 ml of ethanol in sequence, and disperse by ultrasonic wave for 40 minutes to form A solution; add 15 g of acetic acid to 20 ml of ethanol, then add 10 ml of deionized water and 2 g Nano single-crystal lanthanum boride to form a suspension; after magnetically stirring the solution A at a constant temperature of 30°C for 30 minutes, it was added dropwise to the suspension for coating with titanium dioxide; after stirring for 12 hours, the coating was completed, and centrifuged to obtain Titanium dioxide coated nano single crystal lanthanum boride. Vacuum calcined at 400°C for 2h to obtain anatase TiO 2 Coated nano single crystal lanthanum boride.

[0044] After testing, the anatase TiO 2 Coated nano single crystal lanthanum boride is lavender, insoluble in water, density 4.4g / cm 3 . Coating Anatase TiO 2 The O i...

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Abstract

The invention relates to the preparation technology of drugs for treating skin tumors and neoplasm, and aims at providing a preparation for treating the skin tumors and neoplasm and a preparation method thereof. The preparation is an injection product for injection and comprises anatase TiO2-coated nano monocrystal lanthanum boride, gelatin and deionized water; physical and chemical properties ofthe anatase TiO2-coated nano monocrystal lanthanum boride are as follows: the color and density depend on a thickness of a anatase TiO2 coating layer, the color is pink or light purple, the anatase TiO2-coated nano monocrystal lanthanum boride is insoluble in water, and the density is 4.1 to 4.5 g / cm<3>. The main component anatase TiO2-coated nano monocrystal lanthanum boride of the injection is simple in synthetic process and suitable for the industrialized mass production. By adopting the preparation, the surface wound infection can be controlled, the wound can be promoted to be rapidly healed, and the wound can be prevented from being infected. The temperature of an affected part can rise to the gelling temperature of proteins by utilizing the sunlight, the tumor cells and neoplasm cells can be killed, and the treatment effect can be achieved. The preparation has no drug side effect, and is safe and convenient, capable of saving trouble and money, and wide in industrialized prospect.

Description

technical field [0001] The invention relates to a medicine preparation technology for treating skin tumors and neoplasms, in particular to a preparation for treating skin tumors and neoplasms and a preparation method thereof. Background technique [0002] Skin tumor is a cell proliferative disease that occurs in the skin and is a common disease. There are many types of neoplasms that occur in the intradermal or subcutaneous tissue, clinically divided into benign tumors and malignant tumors. Malignant tumors can continue to proliferate, cause metastasis, and threaten life, which is called skin cancer. mainly includes: [0003] 1. Benign skin tumors: seborrheic keratosis, pigmented nevus, hemangioma, etc. [0004] 2. Malignant skin tumors: basal cell carcinoma, squamous cell carcinoma, malignant melanoma and Paget's disease. [0005] 3. Cutaneous T-cell lymphoma, mainly including mycosis fungoides: infiltrating plaques and nodules that occur locally or all over the skin, a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/00A61K47/42A61P35/00A61P17/00
CPCA61K9/0019A61K41/0052A61K47/42A61P17/00A61P35/00
Inventor 李睿刘宾虹李洲鹏
Owner ZHEJIANG UNIV
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