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Tetrad egg yolk antibody soluble powder for resisting swine epidemic diarrhea, swine fever, pseudorabies and infectious gastroenteritis, and preparation method thereof

A technology of porcine epidemic diarrhea and yolk antibody, which is applied in the field of quadruple yolk antibody soluble powder and its preparation, can solve the problems of insufficient immune strength and density, uneven vaccine quality, unsatisfactory therapeutic effect, etc., and achieve rapid curative effect, Easy to save, save the effect of low environmental temperature requirements

Active Publication Date: 2019-01-18
北京普飞特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no effective treatment for swine fever, porcine pseudorabies, porcine epidemic diarrhea and porcine transmissible gastroenteritis. Vaccination prevention is an important means to control the occurrence of the above diseases. However, due to immunosuppression, feed mildew, various Breeding stress, non-standard immunization, uneven vaccine quality, insufficient immune strength and immune density, etc., lead to long-term recessive virus infection and persistent latent infection in pigs, threatening the health of pigs at all times
When individual pigs or pig farms with missed vaccination or immune failure are infected with the above four viruses, antiviral drug symptomatic treatment and antibiotic drugs are mainly used clinically to prevent complications. Once infected with the above four viruses, the therapeutic effect of the above treatment methods is not ideal due to the rapid onset and high mortality rate.

Method used

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  • Tetrad egg yolk antibody soluble powder for resisting swine epidemic diarrhea, swine fever, pseudorabies and infectious gastroenteritis, and preparation method thereof
  • Tetrad egg yolk antibody soluble powder for resisting swine epidemic diarrhea, swine fever, pseudorabies and infectious gastroenteritis, and preparation method thereof
  • Tetrad egg yolk antibody soluble powder for resisting swine epidemic diarrhea, swine fever, pseudorabies and infectious gastroenteritis, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] This example is used to illustrate the preparation of eggs with high immunity to swine fever, pseudorabies, epidemic diarrhea and infectious gastroenteritis. The specific method is as follows:

[0057] (1) Select healthy non-immunized young chickens for laying peaks to be reared in isolation, and strengthen feed nutrition and environmental sanitation to avoid pathogenic infection;

[0058] (2) Young high-yield laying hens processed in the immunization step (1) with swine fever, porcine pseudorabies, porcine epidemic diarrhea and porcine gastroenteritis vaccine, the specific steps are:

[0059] The first time: Immunization of porcine epidemic diarrhea-transmissible gastroenteritis dual attenuated vaccine and dual inactivated vaccine and live swine fever vaccine, the injection volume is 1 / 5 of the pig dose to immunize chickens (that is, 20 pigs are immune to 100 pigs) Chicken), the injection route is subcutaneous injection of porcine epidemic diarrhea-transmissible gastro...

Embodiment 2

[0062] This example is used to illustrate the use of the high-free eggs obtained in Example 1 to prepare a quadruple egg yolk antibody solution. The specific method is as follows:

[0063] (1) Separation of high-free egg yolk:

[0064] One week after the secondary immunization of each vaccine described in Example 1, samples were taken every 7 days to detect the specific antibody titer in the egg yolk corresponding to the antigen in the vaccine, and the egg yolk was used as a control. When non-vaccinated eggs yolk OD 450 The value is less than 0.2, and the egg yolk antibody specific antibody OD of immune vaccine 450 / Non-vaccinated egg yolk OD 450 When the ratio is greater than 5.0, the separated egg yolks are collected. The specific method for separating the egg yolks is: place the high-free eggs obtained in Example 1 in a closed container or in a house, fumigate and sterilize with peracetic acid for 30 minutes, and then send them into an egg yolk separator for egg yolk sepa...

Embodiment 3

[0068] This example is used to illustrate the preparation of the quadruple yolk antibody combination solution.

[0069] Add 5% (w / v) fulvic acid, 15% (w / v) sucrose, 0.02% (w / v) potassium sorbate and 0.02% ( w / v) of sodium azide, fully stirred, that is.

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Abstract

The invention belongs to the technical field of immunology and antibody preparation, in particular to a tetrad egg yolk antibody soluble powder for resisting swine epidemic diarrhea, swine fever, pseudorabies and infectious gastroenteritis and a preparation method thereof. As that dry dextrin and the maltodextrin are use as carriers, Fulvic acid will be adde, Resistance of sucrose, potassium sorbate and sodium azide to classical swine fever, swine pseudorabies, Tetrad yolk antibodies against porcine epidemic diarrhea and porcine infectious gastroenteritis were sprayed onto the carrier surface,A soluble powder with high purity, high stability, high curative effect and easy preservation is prepared, and is a preparation with specificity, good curative effect and quick curative effect for swine fever, swine pseudorabies, swine epidemic diarrhea and swine infectious gastroenteritis, and can effectively prevent and treat that four infectious diseases of swine.

Description

technical field [0001] The invention belongs to the technical field of immunology and antibody preparation, and in particular relates to a quadruple egg yolk antibody soluble powder against porcine epidemic diarrhea, swine fever, pseudorabies and infectious gastroenteritis and a preparation method thereof. Background technique [0002] Swine fever, commonly known as "rotten intestinal fever", is an acute, febrile, contagious infectious disease caused by swine fever virus. Pigs of all ages can be infected and can occur throughout the year. Highly contagious and lethal. It is one of the main infectious diseases threatening the pig industry. Pseudorabies is an infectious disease caused by pseudorabies virus. Pseudorabies virus can infect pigs of all ages, and suckling piglets are the most sensitive. Pseudorabies virus infection in sows can cause estrus disorder, abortion, stillbirth, mummified fetuses, and weak piglets; congenital infection or early infection of pseudorabie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/36A61K39/42A61P31/14A61P31/22C07K16/08C07K16/10C07K1/02
CPCA61K9/1652A61K2039/505A61P31/14A61P31/22C07K16/081C07K16/085C07K16/10C07K2317/11
Inventor 乌仁高娃邱庆
Owner 北京普飞特生物科技有限公司
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