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Novel method for preparing fluorine-containing nano-hydroxyapatite coating on surface of biomedical magnesium alloy

A nano-hydroxyapatite, biomedical technology, applied in coatings, pharmaceutical formulations, electrolytic coatings, etc., to achieve the effects of uniform coating morphology, easy control and process stability

Inactive Publication Date: 2018-06-15
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, double-pulse electrodeposition is used for the fluorinated magnesium alloy, so that the fluorine ions released from the fluorine conversion coating when the substrate acts as an anode during the double-pulse process participate in the nucleation and growth of HA, and finally obtain fluorine-containing nanorod-shaped hydroxyl groups. Apatite (FHA), has not been reported at home and abroad

Method used

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  • Novel method for preparing fluorine-containing nano-hydroxyapatite coating on surface of biomedical magnesium alloy
  • Novel method for preparing fluorine-containing nano-hydroxyapatite coating on surface of biomedical magnesium alloy
  • Novel method for preparing fluorine-containing nano-hydroxyapatite coating on surface of biomedical magnesium alloy

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Experimental program
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Effect test

Embodiment 1

[0032] A fluorine-containing nano-hydroxyapatite coating was prepared on the surface of a Mg-2.02wt%Zn-0.80wt%Ca alloy by a double-pulse electrodeposition method, and the preparation steps were as follows:

[0033] (1) Substrate material preparation: cutting the magnesium alloy wire 12mm×4mm cylinder, use 240 # 、400 # 、600 # , 800 # 、1000 # The surface of the SiC water abrasive paper was polished in turn, rinsed with deionized water, and then ultrasonically cleaned with an acetone / absolute ethanol mixed solution with a volume ratio of 1:1 at room temperature for 5 minutes to remove surface oil stains, and the base material was taken out and air-dried for later use ;

[0034] (2) Put the cleaned substrate material in a plastic beaker for fluorination treatment, the concentration of hydrofluoric acid is 40wt%, and the fluorination treatment time is 20 hours. After cleaning the substrate material that has undergone fluorination treatment with deionized water dry;

[0035]...

Embodiment 2

[0049] Taking AZ31 as the base material, the preparation steps are as follows:

[0050] (1) Substrate material preparation: cutting the magnesium alloy wire 12mm×5mm cylinder, use 240 # 、400 # , 800 # 、1000 # The surface of the alloy was polished with SiC water-grinding paper in turn, rinsed with deionized water, and then ultrasonically cleaned with acetone / absolute ethanol mixed solution with a volume ratio of 0.8:1 at room temperature for 10 minutes to remove surface oil stains, and the base material was taken out and air-dried naturally;

[0051] (2) Perform fluorination treatment on the cleaned substrate material, the concentration of hydrofluoric acid is 30wt%, the fluorination treatment time is 24 hours, and the substrate material that has undergone fluorination treatment is cleaned with deionized water and then dried;

[0052] (3) Configure electrolyte: Ca(NO 3 ) 2 4H 2 O 21.5mmol / L

[0053] NH 4 h 2 PO 4 12.8 mmol / L

[0054] NaNO 3 0.09 mmol / ...

Embodiment 3

[0060] Prepare a composite coating on the surface of high-purity magnesium (99.99%) to obtain fluorine-containing nano-hydroxyapatite. The preparation steps are as follows:

[0061] (1) Substrate material preparation: cutting the magnesium wire 12mm×3mm cylinder, use 240 # 、600 # , 800 # 、1000 # The surface of the alloy was polished with SiC water-grinding paper in turn, rinsed with deionized water, and then ultrasonically cleaned with acetone / absolute ethanol mixed solution with a volume ratio of 0.6:1 at room temperature for 10 minutes to remove surface oil stains, and the base material was taken out and air-dried naturally;

[0062] (2) Perform fluorination treatment on the cleaned base material, the concentration of hydrofluoric acid is 20wt%, the fluorination treatment time is 30 hours, and the base material that has undergone fluorination treatment is cleaned with deionized water and then dried;

[0063] (3) Configure electrolyte: Ca(NO 3 ) 2· 4H 2 O 0.042 mol / L ...

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Abstract

A novel method for preparing a fluorine-containing nano-hydroxyapatite coating on the surface of a biomedical magnesium alloy comprises the following steps that (1) a cleaned pure magnesium or magnesium alloy substrate material is immersed into 20-40wt% of hydrofluoric acid for 18-30 h, then cleaned in deionized water and dried; (2) an electrolyte is prepared, the concentration of Ca<2+> in the electrolyte is 10.5 mmol / L-42 mmol / L, the concentration of H2PO4<-> in the electrolyte is 6.3 mmol / L-25 mmol / L, the Ca / P molar ratio is 1.6-2.0, the concentration of NaNO3 in the electrolyte is 0.058 mol / L-0.117 mol / L, and the pH value of the electrolyte is adjusted to be 4.5-5.5 for standby application; and (3) the pure magnesium or magnesium alloy substrate material treated in the step (1) servingas a cathode and a graphite electrode serving as an anode are put into the electrolyte in the step (2), hydroxyapatite is deposited on the surface of the fluorinated substrate material through a dipulse electrodeposition method, and thus the fluorine-containing nano-hydroxyapatite coating is obtained.

Description

technical field [0001] The invention belongs to the technical field of preparation of pure magnesium and magnesium alloy biomedical materials, and in particular relates to a new method for preparing a fluorine-containing nano-hydroxyapatite coating on the surface of a biomedical magnesium alloy. Background technique [0002] Traditional metal materials used in the field of bone implants mainly include titanium and its alloys, stainless steel and cobalt-based alloys, etc., but the toxic metal ions released by the corrosion of the above metals and their alloys in the body fluid environment will cause local allergies or inflammation, and cause The mismatch of its mechanical properties with that of human bone will produce stress shielding effect. In addition, due to its non-degradability, for short-term implant applications, the implant must be removed through a second operation, which increases the patient's pain and medical expenses. [0003] Using degradable biomaterials as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/12C25D5/18A61L27/04A61L27/32A61L27/50
CPCA61L27/047A61L27/32A61L27/50A61L2400/12A61L2420/08C25D5/18C25D9/12
Inventor 关绍康冯雅珊王利国朱世杰常蕾王俊任晨星王剑锋周轶凡
Owner ZHENGZHOU UNIV
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