Anticoagulation high polymer biomaterial as well as preparation method and application thereof

Abstract

The invention discloses an anticoagulation high polymer biomaterial which comprises a substrate layer, an anticoagulation coating, and a plasma polymerization layer positioned between the substrate layer and the anticoagulation coating, wherein the substrate layer is made of a biomedical material; the plasma polymerization layer is an allylamine plasma polymerization membrane layer deposited on the substrate layer; the anticoagulation coating is an anticoagulant layer fixed on the plasma polymerization layer; and the anticoagulants comprise hirudin, heparin and the like. Anticoagulant molecules are fixedly grafted on the material surface by utilizing the pulsed plasma technology and surface heparin grafting method, and effective molecule orientation is remained by heparin molecules, so the anticoagulant performance is close to the performance of heparin molecules in the solution. Meanwhile, the heparin molecules are difficultly scoured off by blood, the persistence and stability of the anticoagulation effect are guaranteed, and the service life is long. The invention further discloses a preparation method and application of the anticoagulation high polymer biomaterial.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to an anticoagulant polymer composite material and its preparation method and application. Background technique [0002] Because of its excellent mechanical properties and mechanical durability, polymer materials are widely used clinically in medical devices that come into contact with human blood and tissues, such as hemodialysis systems, extracorporeal circulation systems, artificial heart valves, and cardiac pacemakers. , artificial blood vessels, vascular stents, surgical lines and catheters and their components. However, when the blood is in contact with the surface of these medical devices when used in a patient, the protein in the blood is first adsorbed on the surface of the device, then the platelets, and finally leads to the formation of a thrombus. The thrombus formed on the surface of the device, even a very small thrombus, once transported by the blood into the bl...

AI Technical Summary

Problems solved by technology

However, the disadvantages of the heparin physical adsorption method are: heparin is easy to lose and the anticoagulant effect is not long; while the chemical reaction between the carboxyl group of heparin and the amino group of the activating material or the covalent coupling through the adhesive or spacer, through the covalent bond The disadvantages of heparin are: the conformation of heparin is limited, and the anticoagulant activity is significantly reduced; the same disadvantages are similar to using the ammonolysis method and grafting heparin after polydopamine coating on the surface of the material

The materials for immobilizing anticoagulants in existing methods are also limited, for example, many inert materials such as silica gel are difficult to immobilize anticoagulant materials through existing methods

[0004] Therefore, there is no effective anticoagulant coated medical device in the market at present.

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